Search PubMed⌕ Search

Biomedical subjects

T M Kovalenko

Publications and source records attributed to T M Kovalenko.

At least 19 recordsLinked to original sources
PubMed2006

[Neuroprotective effect of quercetin during experimental brain ischemia].

The neuroprotective action by water-soluble form of quercetin was examined in gerbils after transient forebrain ischemia. The animals were exposed to 7 min of bilateral common carotid artery occlusion. Hippocampal CA 1 area was examined 7 days after ischemia-reperfusion. The average density of CA1 pyramidal neurons and GFAP-positive glial cells were counted in sham operated group, in ischemic group and in the groups treated with water-soluble form of quercetin. It was shown that quercetin revealed protective effect by decreasing of delayed neuronal death and reducing reactive astrogliosis after ischemia-reperfusion.

Animals↗
PubMed2004

[Structural organisation of CA1 zone in the hippocampus of rats in the experimental brain ischemia].

The dynamic of structural and ultrastructural changes of CA1 area of the hippocampus was examined in rats after 10 or 15 min of global ischemia (4 vessels occlusion, 4VO) followed by reperfusion. In the early period of reperfusion (15 min, 2 h), the structural changes in synaptic terminals were observed, without any significant signs of neuronal damage. These changes consisted in (i) the increase of the relative number of perforated and multiple synapses, and (ii) the synaptic vesicles rearrangement. Clear neuronal damage appeared morphologically at 24 h, and then developed for 3-6 days and resulted in the delayed damage and death of the hippocampal neurons.

Animals↗
PubMed2002

[Thrombocyte function during normal and complicated pregnancies].

Research of functional changes in the circulating thrombocytes at physiological pregnancy and EPH--gestosis in women was conducted with methods of an electron microscopy and microcoagulogy. Some peculiarities of the release reactions by thrombocytes which determine an extra thrombocyte release of the content from their cytoplasmatic granules have been determined.

Adolescent↗
PubMed1999

[Endothelial cells during cultivation (a comparative analysis of methodological approaches)].

In the paper various methods for isolation and cultivation of endothelial cells are compared on the basis of the own data. The comparative analysis of the methods for isolation of endothelial cells from the vessel explant and by enzymatic treatment of aorta or coronary vessels is carried out. The methodical approaches to obtaining pure culture of endotheliocytes are being analysed.

Animals↗
PubMed1995

Experimental thyrotoxic myopathy: radioautography of protein synthesis in skeletal muscle and motor neurons of spinal cord.

The total protein synthesis was studied in skeletal muscle and spinal motor neurons in experimental thyrotoxic myopathy (TM) mice by using radioautography with 3H-methionine. A significant increase of mean specific radioactivity was found in motor neurons of mice with TM. No statistical differences were established in the level of 3H-methionine inclusions into muscle fibre proteins of experimental and control animals. Thus, the total protein synthesis in motor neurons is significantly increased with TM, while there is no change in the skeletal muscle. Our data suggest that muscular weakness in TM is not the consequence of protein metabolism disorders in skeletal muscle fibres.

Animals↗
PubMed1994

[Delivery in pregnant women with previously operated on uterus].

The delivery in 66 pregnant women previously operated on the uterus is analyzed. 40% of women with cicatrices on the uterus after cesarean section gave birth to children via the natural route. In order to improve the safety of spontaneous labor, echographic examination of the lower segment of the uterus in labor was carried out in these women, as well as ultrasonic cervicometry and monitoring of the detachment and delivery of the placenta.

Cesarean Section↗
PubMed1978

[Myopathy (terminology, clinical picture, and diagnosis)].

The paper deals with a description of the clinical picture and diagnosis of the main types of myodystrophies taking into account formes of muscular damages and a trend of generalization of a pathological process at the early phase of the disease. The clinical picture of endocrine myopathies was also studied. The authors revealed almost the same formula of muscular damages. Muscles of the pelvic girdle and femurs mainly suffered and to a lesser degree--muscles of the shoulder girdle and shoulders. According to the data of the clinical picture, histopathology and electromyography endocrinic myopathies are phenocopies of hereditary myodystrophies.

Adolescent↗
PubMed1978

[Endocrine myopathies. Muscular lesions in thyrotoxicosis].

The authors studied 42 patients with endocrine myopathy. In thyrotoxic myopathy prevalent muscle lesions of the pelvic girdle and femur were found. EMG studies (with the aid of point electrodes), histological and histochemical studies of the muscles in patients with thyrotoxicosis indicate a primary muscular character of the atrophies. The report contains descriptions of pathomorphological and histochemical changes in the muscles in experimental thyrotoxic myopathy.

Adult↗
PubMed1977

Chronic spinal muscular atrophy simulating facioscapulohumeral type and limb-girdle type of muscular dystrophy. Report of two cases.

Two cases of chronic spinal muscular atrophy simulating the clinical picture of the facioscapulohumeral type and limb-girdle type of muscular dystrophy are reported. Both patients had a waddling gait, Gowers' maneuver in arising, terminal atrophies and pseudohypertrophies of some muscles, marked fasciculations, and fascicular tremor. The electromyogram revealed signs of anterior horn cell disease. Calf muscle biopsy (case 2) revealed 'myopathic' changes.

Chronic Disease↗
PubMed1976

[Effect of cortisone on post-traumatic regeneration of mammalian skeletal muscle].

Prolonged administration of cortisone to sexually immature rabbits and rats, in which m. tibialis anterior was injured preliminarily, inhibited the process of regeneration of the skeletal muscle tissue; this was expressed in the retarded growth of myosymplasts and of the muscle tubes. By the 15th postoperative day experimental rabbits (in comparison with control) showed a lesser area of muscle component of the regenerated tissue. Analysis of the intensity of methionine-H3 incorporation into the regenerating elements of the muscle tissue demonstrated a significant reduction of the label incorporation into the nuclear and cytoplasmic proteins of the myosymplasts of rats to which cortisone was given. Inhibition of the protein synthesis at the early stage of differentiation of the muscle tissue was expressed to a lesser extent than in the mature differentiated muscle fibers of the intact muscle.

Animals↗