Biomedical subjects

T M Ignatova

Publications and source records attributed to T M Ignatova.

24 records · Page 2Linked to original sources

PubMedDate not supplied

[Extrahepatic manifestations of chronic viral liver diseases].

The study of large groups of patients with chronic liver diseases of viral etiology (including those induced by HBV and HCV) has revealed extrahepatic manifestations which by their mechanisms formed 2 groups. The first group represents disorders related to delayed hypersensitivity in combination with immunocomplex reactions (lesions of the joints, skeletal muscles, lungs, myocardium, etc). The second group includes disorders of primarily immunocomplex genesis (vasculitis): skin vasculitis, Raynaud's syndrome, nodular periiarteritis, mixed cryoglobulinemia, etc.). Special group represents diseases of blood: immune cytopenias, monoclonal immunoglobulinopathy, malignant lymphoproliferative diseases. These findings and literature data on extrahepatic replication of HBV and HCV validate the diagnosis of "chronic generalized HBV or HCV infection" with listing of all manifestations of these infections.

Cryoglobulinemia↗

PubMedDate not supplied

[Pathogenesis of chronic hepatitis C].

Recent investigations revealed a specific interaction of virus with the host immune system. HCV is able to escape and modify the host's immune response, notably the rate of production and specificity of rheumatoid factor--the basis for mixed cryoglobulins and various non-organospecific and some organ-specific autoantibodies. Further studies are required to decode the mechanisms of virus-host immune system interaction for substantiating the treatment and prevention of HCV infection.

Hepacivirus↗

PubMedDate not supplied

[Chronic viral hepatitis--one of the most important problems of current medicine].

Main aspects of the study of chronic virus infection now cover clinico-morphological characteristics, prognosis of chronic liver diseases (CLD) by HBV and HCV; characteristics of extrahepatic lesions produced by HBV and HCV; features of CLD of mixed etiology (viral and alcoholic); treatment of CLD of viral etiology. The hypothesis is suggested on the generalized character of HBV and HCV infection. Approach to the treatment of chronic viral hepatitis including extrahepatic manifestation is proposed.

Female↗

PubMedDate not supplied

[Viral hepatitis C].

This review is indicative of a considerable progress in the study of viral hepatitis C: HCV biology (its structural and antigenic analysis, genotype heterogenicity and genome mutation, mechanisms of replication), serological diagnosis, epidemiology, pathogenesis and clinico-morphological characteristics of liver involvement, systemic manifestations as well as carcinogenesis in HCV contamination. There exist data in favour of HCV role in a wide spectrum of pathology in parallel to what was earlier established in relation to HCV.

Autoimmune Diseases↗

PubMedDate not supplied

[The incidence of detecting HB viral infection in the families of patients with kidney diseases].

A total of 33 families were surveyed with a view to determine the presence of viral hepatitis B markers in persons with diagnosed renal diseases. In all patients markers of hepatitis B virus infection (HBsAg, anti-HBs antibodies, anti-HBc total and IgM antibodies) were determined in the enzyme immunoassay. Those families in which examinees with renal pathology were found to have markers of hepatitis B virus infection exhibited a high level of contamination with hepatitis B virus. A high proportion of examinees with viral hepatitis B was established in the families where mothers were found to have markers of hepatitis B virus infection. These facts indicate that everyday contacts play an important role in the transmission of the virus. The study points out that in the family foci of hepatitis B virus infection non-manifest or slightly manifest forms of this infection are mainly registered.

Adult↗

PubMedDate not supplied

[Comparative morphologic characteristics of viral hepatitis B and C].

Using liver biopsies in chronic HBV and HCV infections and their combination, the authors found between them morphological difference represented by nonspecific morphological markers. The combination of fat and hydropic hepatocytes degeneration, their heterogeneity, lymphoid follicles of various location and maturation degree, sinusoidal cell hyperplasia, accumulation of lymphocytes and macrophages in sinusoids, destruction, proliferation and sclerosis of ductules are of a high significance in hepatitis C. Etiological markers of hepatitis B are so-called ground-glass hepatocytes and "sand" nuclei. Various combination of these markers are characteristic for HBV and HCV co-infections with predominance among them of a replicating virus.

Biomarkers↗