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Biomedical subjects

T M Cox

Publications and source records attributed to T M Cox.

130 records · Page 8Linked to original sources
PubMed1979

Rôle of calcitonin in diarrhoea associated with medullary carcinoma of the thyroid.

Severe watery diarrhoea in a patient with medullary thryoid carcinoma and high calcitonin levels was associated with increased distal ileal flow. Plasma from the patient inhibited small intestinal fluid absorption in dogs without affecting mucosal cyclic AMP levels. When calcitonin was removed from the plasma, the effect in experimental bowel loops was abolished but could be restored on restitution of comparable hormone levels with pure calcitonin. These studies, combined with the failure to find evidence of increased prostaglandin activity in the patient, suggest that circulating calcitonin may be a major cause of the diarrhoea in medullary thyroid carcinoma.

Animals↗
PubMed1978

Uptake of iron by duodenal biopsy specimens from patients with iron-deficiency anaemia and primary haemochromatosis.

Iron uptake by human duodenal mucosa in vitro was considerably higher in iron-deficient patients than in controls. In biopsy specimens taken after treatment with iron, uptake fell to normal levels, although total iron in the mucosa remained low. In iron-overloaded patients with primary haemochromatosis, there was inappropriately high uptake of iron by the biopsy specimens. Kinetic analysis suggested that this was the result of affinity for iron being increased in a carrier in the enterocyte.

Anemia, Hypochromic↗
PubMedDate not supplied

Skeletal muscle weakness and dysphagia caused by acid maltase deficiency: nutritional consequences of coincident celiac sprue.

BACKGROUND: A 30-year-old woman with celiac sprue had progressive weight loss, myalgia, limb-girdle weakness, and dysphagia. METHODS AND RESULTS: Barium swallow showed an atonic esophagus, and scintigraphic study confirmed esophageal dysmotility. Skeletal muscle biopsy showed characteristic appearances of acid maltase deficiency, which was confirmed by a reduction of leukocyte acid alpha-glucosidase activity. CONCLUSIONS: Nutritional factors may have accelerated the presentation of the lysosomal storage disorder. This is the first reported case of dysphagia caused by esophageal motor weakness in acid maltase deficiency.

Adult↗