Biomedical subjects

T M Brady

Publications and source records attributed to T M Brady.

21 records · Page 2Linked to original sources

PubMedDate not supplied

Percutaneous transthoracic needle biopsy of the lung: review of 612 lesions.

PURPOSE: The results and complications of 651 pulmonary fine-needle aspiration biopsies (FNABs) were reviewed. The number of needle passes and needle size were correlated to pneumothorax and chest tube placement rates. MATERIALS AND METHODS: FNAB of the lung was performed on 651 occasions in 612 patients with 18- to 22-gauge Franseen needles. Diagnostic rates were calculated. The number of needle passes performed and needle size used were evaluated for their association with pneumothorax and subsequent chest tube placement. RESULTS: Diagnostic accuracy was 94% with sensitivity for malignancy of 95%. Positive and negative predictive values were 99.5% and 90%, respectively. Pneumothorax occurred in 26.9% of patients with 9.2% requiring chest tube placement. Increasing numbers of needle passes and larger needle sizes did not increase the rates of pneumothorax or chest tube placement. CONCLUSIONS: FNAB of the lung has excellent diagnostic rates and remains the procedure of choice for diagnosing pulmonary lesions. This large study contradicts perceptions that pneumothorax and chest tube placement rates decrease with thinner needles and fewer passes.

Adult↗

PubMedDate not supplied

Angiographic nephrectomy using iodinated contrast agent.

Diatrizoate meglumine and sodium (Renografin-76) was perfused in an obstructed renal artery in 13 dogs. Intense and prolonged accumulation of contrast agent ("contrast staining") was achieved in all animals. Repeat injection was frequently necessary to enhance staining. Renin output from the stained kidneys was lower than that from the opposite kidneys. Angiography at 14-18 weeks demonstrated a marked decrease in renal size in all dogs, with complete occlusion of the renal artery in two dogs. No collateral circulation was discerned. Grossly, all experimental kidneys were uniformly shrunken. Histologically, diffuse renal infarction was evident with coagulative necrosis. Contrast staining is an effective method for uniform destruction of renal tissue.

Animals↗

PubMedDate not supplied

Renal artery occlusion and infarction with Sotradecol.

Sodium tetradecyl sulfate 3% (Sotradecol) was perfused into a proximally obstructed renal artery in ten random-source adult dogs. In all animals, the intra-arterial injections of Sotradecol produced immediate thrombosis of the renal arteries. Angiographic studies, lasting up to ten weeks, on eight dogs demonstrated persistent occlusion. In one dog, unintentional thrombosis occurred in the opposite renal artery due to reflux of Sotradecol. Histopathologic studies showed total obliteration of the renal arteries through organized thrombosis, intimal sclerosis, and luminal collapse. In all dogs, the kidneys were not visible, and diffuse renal infarction was confirmed by histologic studies of five dogs.

Animals↗