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Biomedical subjects

T M Anderson

Publications and source records attributed to T M Anderson.

65 records · Page 4Linked to original sources
PubMed1981

Arthrographic and radiologic evaluation of prosthetic joints.

Arthrography is indicated for the evaluation of a prosthetic joint for suspected infection, possible loosening based on clinical or plain radiographic findings, or unexplained pain following the insertion of a prosthesis. Interpretative difficulties most frequently occur when the acetabular component of the hip is evaluated. Also, the femoral component of a total knee arthroplasty is not optimally evaluated with arthrography. The decision to revise a loose prosthetic component is based on a clinical judgment. Arthrographic findings may facilitate this decision, but the decision does not depend solely on the arthrographic results. Rather, they must be evaluated in conjunction with other clinical and radiographic findings to eliminate false positive studies, thereby avoiding unnecessary surgery. In the presence of an equivocal arthrogram, radionuclide bone imaging shows promise as an adjunct for evaluating possible failure of a prosthetic component. It is also useful for evaluating the suspected failure of the femoral component of a knee prosthesis.

Bone Cements↗
PubMed1979

Inhibition of mammary tumorigenesis in carcinogen-treated Lewis rats by suppression of prolactin secretion.

One hundred sixty-eight female Lewis rats were treated intragastrically with 10 mg 7,12-dimethylbenz[a]anthracene at 56 and 63 days of age. Pituitary prolactin secretion was suppressed in one-half of these rats by daily sc administrations of 2-bromoergocryptine mesylate (CB-154; 0.4 mg/100 g body wt) from 29 to 90 days of age (series 1) and from 90 to 140 days of age (series 2). Treatment with CB-154 was initiated prior to the onset of palpable mammary carcinomas. Control rats were given injections of saline. Inguinal mammary glands were excised from 10 control and 10 CB-154-treated rats at the cessation of saline and CB-154 treatments and examined for hyperplastic nodules (HN). The remaining rats were palpated weekly for mammary carcinomas (MC) and killed at 200 days of age. Mean number of HN per rat, mean number of MC per rat, and percent of rats with MC were, respectively: series 1--controls, 0.6, 1.5, and 68; CB-154 treatment, 0.5, 1.1, and 62; series 2--controls, 10.4, 2.0, and 94; CB-154 treatment, 5.1, 1.1, and 56. The number of HN and MC was only slightly reduced in rats when prolactin was suppressed during carcinogen treatment (series 1) but markedly reduced when prolactin was suppressed after carcinogen treatment (series 2). These results provide evidence that prolactin is involved in the early development of mammary dysplasias in the carcinogen-treated female Lewis rat.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1976

Efficacy of emergency radionuclide perfusion lung studies.

Over a one-year period, 206 patients with suspected pulmonary embolism received gamma camera perfusion lung images on an emergency 24 hr. basis. Clinical diagnosis listed pulmonary embolism in 37 of 39 patients whose images showed a high probability of it, in 28 of 69 whose images were abnormal but rated uncertain probability, and 5 of 98 with normal images. Retrospective clinical evaluation indicated 89 of the emergency images to be considered important, 95 contributory, and 22 not helpful in clinical management. As a result of the images, 80 patients were placed on heparin therapy of 198 considered for it, and 22 of 29 patients referred for hospital admission were placed on an outpatient basis. Delay in obtaining lung images creates the possibility of diagnostic uncertainty in interpreting the image.

Adolescent↗
PubMedDate not supplied

The surgical management of pulmonary metastasis: current concepts.

Lung metastases have been found in 25-30% of all patients with cancer at autopsy. Those patients satisfying criteria for surgical resection represent a much smaller subgroup. Given the potentially curative nature of pulmonary metastasectomy in the absence of disseminated disease, it has become widely accepted as an important treatment option for a variety of malignancies with metastasis to the lungs. A standardized approach remains unfounded however, given limited numbers of patients, various histologic subtypes and few published studies utilizing randomized prospective methodology.Ultimately, the development of metastasis represents a major determinant of survival for patients with cancer. Pulmonary metastasectomy is an important treatment modality for patients with metastatic pulmonary disease. The indications for pulmonary metastasectomy and the surgeon's role in pulmonary metastatic disease continue to evolve. Future prospective studies and the compilation of comparable data yielding prognostic factors for specific histologies will better define indications for resection.

Humans↗
PubMedDate not supplied

Malignant pleural mesothelioma: a problematic review.

Malignant pleural mesothelioma is a rare tumor that has been difficult to study. Because of disappointing treatment results, malignant pleural mesothelioma has remained an area of active research and development. A clinicopathologic review is performed in light of several problematic issues involving diagnosis, staging, natural history, and treatment. Multimodality treatment with surgery followed by adjuvant local and systemic therapy remains the most optimal therapy. Many controversial issues still exist in the treatment of malignant pleural mesothelioma. In the ensuing years newer staging systems, better preoperative staging, newer experimental therapies, and the localization of patients at expert centers will undoubtedly have an impact on disease management.

Adult↗
PubMedDate not supplied

Computed tomography and ultrasonography of carcinoma in duplication cysts.

The CT and ultrasound findings of malignancy arising in walls of alimentary tract duplication cysts are previously unreported. We describe two cases where identification of both cyst and tumor nodule and separation of the mass from other visceral organs was achieved. We review the English literature reporting this unusual condition and suggest that CT and ultrasound are of great value in accurate preoperative diagnosis.

Adenocarcinoma↗