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Biomedical subjects

T Luukkainen

Publications and source records attributed to T Luukkainen.

At least 109 records · Page 6Linked to original sources
PubMed1978

Return of ovarian function after abortion.

The first menstrual cycle after a therapeutic abortion was studied in eighteen women by measuring plasma oestradiol and progesterone concentrations and the urinary excretion of LH until the first menstruation. The plasma concentrations of oestradiol and progesterone declined rapidly, reaching low values as early as the second day after the abortion. An increase in plasma oestradiol levels was observed from the seventh post-abortal day onwards. P peak of short duration in the plasma progesterone concentrations occurred during the increased oestradiol synthesis. The concentration of progesterone during the luteal phase of the cycle was lower than in a normal cycle, indicating an inadequate luteal function. Return of ovulation was observed in 83% of patients during the first cycle; as judged by a biphasic oestradiol profile in plasma, a mid-cycle LH peak, and subsequent elevation of progesterone. The first LH peak was observed 16 days after the abortion. The rapid return of the ovulatory function makes immediate post-abortal contraception a necessity.

Abortion, Therapeutic↗
PubMed1978

A radioimmunoassay of oestrone in plasma. Plasma levels of oestrone and oestradiol in oophorectomized Rhesus monkeys during treatment with subcutaneous implants containing oestrone.

A highly specific antiserum to oestrone was used to develop a sensitive radioimmunoassay. Plasma was generally analysed without prior separation of the oestrogens. A small amount of plasma (0.1-0.2 ml) was extracted once with diethyl ether. The above and previously described radioimmunoassays were used to estimate plasma levels of oestrogens in oophorectomized monkeys treated with subcutaneous oestrone implants. Three monkeys received a rod containing 40 mg of oestrone. The rods were kept in place for about one year. The release rates from the rods were calculated. The oestrone plasma levels were initially high (370-500 pg/ml). In about 3 months they had fallen to a level of 50-100 pg/ml which was maintained till the removal of the rods. A rise in the oestradiol plasma levels was also observed. It is concluded that rods are suitable for administration of oestrone.

Animals↗
PubMed1976

Long-term contraception with norethindrone subcutaneous capsules.

Norethindrone (NET) contained in silicone rubber, for slow release, was implanted subcutaneously. The rate of release of NET was 10-12 mug/day/10 mm length of the silicone rubber. The total length of the implants used varied from 100 mm to 200 mm. During the whole observation time 562 women months, 14 a-cidental pregnancies occurred. The pregnancy rate decreased with increasing length of implants. The implants produced a transient ovulation suppression, which subsided in four to five cycles. The plasma levels of NET stabilized at a level which was less than that reached by daily oral administration of 350 mug of NET. The high pregnancy rate and the great number of implants required render the method impractical for contraception. However, the active life-span of implants is three years and because there were few minor side-effects, the method was well accepted.

Contraception↗
PubMed1975

Biodegradable polylactate as a steroid-releasing polymer: intrauterine administration of d-norgestrel.

Polylactate film containing 30 per cent or 4.5 mg. of d-norgestrel was fixed around a plain T-IUD and the device was inserted into the uterine cavity. Norgestrel was gradually released into the systemic circulation, blood levels being highest during menstruation. Plasma estradiol and progesterone determinations revealed that cyclic ovarian function was maintained during the intrauterine administration of norgestrel; however, marked local effects on the endometrium resulted. The amount of menstrual bleeding was reduced.

Adult↗