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Biomedical subjects

T Lotti

Publications and source records attributed to T Lotti.

At least 127 records · Page 7Linked to original sources
PubMed1988

Modulation of growth of melanoma.

Combined heparin-cortisone treatment induces regression of growth in a variety of murine tumors including melanoma. We injected 92 inbred C 57 b1/6 male mice each with 5 X 10(5) melanoma cells (B16, B16 F1, and B16 A6 lines) with different metastatic potential. Heparin (400 U/ml) and cortisone acetate (250 mg/kg SC injections) were given daily. Control experiments were performed both with the administration of no drugs and with administration of cortisone alone. Plasminogen activator activity, which is notoriously related to tumor growth, was evaluated using fibrin plate technique in 10 fragments taken before and 20 days after the combined heparin-cortisone treatment of B16 F1 and B16 A6 melanomas. The combined heparin-cortisone treatment slowed tumor growth, but no tumour regression was observed. Cutaneous fibrinolytic activity appeared increased in all specimens after the treatment.

Animals↗
PubMed1988

Multicentric reticulohistiocytosis. Report of three cases with the evaluation of tissue proteinase activity.

Three cases of multicentric reticulohistiocytosis showing typical clinical, histologic, and ultrastructural findings are reported. In one, gastric cancer occurred; in the other two cases, severe polyarthritis was the only detectable internal involvement. The serine proteinases, urokinase and tissue-type plasminogen activator, were evaluated both with the autohistographic technique and spectrophotometric assay in lesional skin and synovia. Urokinase levels appeared grossly increased in the lesional synovia and moderately increased in the lesional skin. We suggest that urokinase, presumably released by the activated proliferating histiocytes, may play a major role in the extracellular matrix degradation leading to erosion of cartilage and adjacent bone in multicentric reticulohistiocytosis.

Adult↗
PubMed1987

Cutaneous fibrinolytic activity in primary hypertrophic osteoarthropathy.

Cutaneous fibrinolytic activity was investigated in 13 patients affected with Primary Hypertrophic Osteoarthropathy in the advanced phase. Biopsies were taken from periungueal skin of the ippocratic finger and from the dorsum of the first phalanx: cutaneous fibrinolytic activity was investigated with Todd's autohistographic method as modified by Lotti et al., showing increased activity in periungueal skin (10/13) and normal in the apparently uninvolved skin (9/13). We suggest that the increase in plasminogen activator activity, in the advanced phase of the disease, may be related to the increased growth of the connective tissue that is characteristic of the disease.

Adult↗
PubMed1986

Increased cutaneous fibrinolytic activity in aquagenic pruritus.

Aquagenic pruritus is a disease in which itchy prickling skin discomfort is evoked by contact with water at any temperature without observable cutaneous lesions. Little is known about its etiology and pathogenesis. Previous reports show that increased levels of blood histamine and cutaneous mast cell degranulation are present before water exposure and that they increase still further with water challenge. This paper shows that fibrinolytic activity is markedly increased both before and after water exposure, while circulating fibrinolytic activity is normal before water exposure in three cases of aquagenic pruritus. A patient who was asymptomatic at the time of the study had no observed increase in fibrinolytic activity either before or after water challenge, suggesting that the remission of symptoms of aquagenic pruritus and normalization of cutaneous fibrinolytic activity are interdependent factors.

Adult↗
PubMed1986

[Current diagnostic technics in the prediction of the functional recovery of a urographically silent kidney].

25 patients with a silent kidney, because of obstructive uropathy, have been studied. Authors' aim was to find out some parameters which could be able to predict renal function recovery once the obstruction was removed. 99m Tc DTPA renal scintiscanning, renal ultrasonography, and the study of renal clearances on the urine obtained via a percutaneous nephrostomy were executed. The authors observed that when the nuclide renal uptake is absent a minimal functional recovery is still possible and it may be foretold only analysing the urine collected through a percutaneous nephrostomy.

Adult↗
PubMed1983

Fibrin deposits and fibrinolytic activity in Schonlein-Henoch syndrome.

Previous reports have shown that alterations in cutaneous and plasmatic fibrinolytic activity are found in cutaneous necrotizing vasculitis (CNV). In a combined investigation with direct immunofluorescence and autohistographic evaluation of tissue fibrinolytic activity in the lesional skin of 20 subjects affected by Schonlein-Henoch (SH) syndrome, there was a marked decrease in cutaneous fibrinolytic activity in SH syndrome accompanied by deposits of fibrin-like material at the dermo-epidermal junction and around the small blood vessels of dermis in affected skin. These data suggest some interactions between decreased fibrinolytic activity, fibrin deposits, and the tissue damage in the development of skin changes in SH syndrome.

Child↗
PubMed1979

Rectal bladder. Indications, contraindications and advantages.

Experience is reported on more than 700 patients submitted to rectal bladder over the last 20 years. The main indications were total cystectomy due to bladder neoplasias and palliative surgery in patients in whom cystectomy was impossible. The rectal bladder, even of the Mauclaire type, is the most useful and best accepted urinary diversion. Separation of urime from faeces avoids serious ascending infections and involvement of renal function. These observations are supported by the long survival of patients submitted to derivative surgery in the absence of neoplastic disease.

Humans↗