Search PubMed⌕ Search

Biomedical subjects

T Lombardi

Publications and source records attributed to T Lombardi.

At least 37 records · Page 2Linked to original sources
PubMed1998

Minor salivary gland hyalinisation and amyloidosis in low-grade lymphoma of MALT.

Two patients with low-grade lymphoma of mucosa-associated lymphoid tissue (MALT) arising in primary Sjögren's syndrome developed solitary nodules in their lips. Histologically both lesions showed enlargement and hyalinisation of single minor salivary glands with acinar atrophy, loss of most ducts and conversion into almost acellular sclerotic eosinophilic masses. In one case the lesion was shown to contain an amyloid component. No amyloid was detected in the second case but deposition of collagen and basement membrane and sclerotic neoplasm were excluded.

Amyloid↗
PubMed1997

Hybrid central giant cell granuloma and central odontogenic fibroma-like lesions of the jaws.

Ten lesions from eight cases are presented of a rare intra-osseous jaw lesion with the combined histological features of giant cell granuloma and central odontogenic fibroma. Lesions arose over a wide age range and presented as monolocular or multilocular radiolucencies with cortical expansion and, in one case, perforation. Two lesions recurred after curettage, one being eradicated by a second curettage and one by conservative excision. Histologically, zones of typical giant cell granuloma lay in a fibrous stroma containing islands, strands and clusters of epithelial cells. Islands often contained duct-like spaces or hyaline basement membrane globules. Trabeculae of osteoid were present in five lesions. Recurrent lesions showed features identical to the initial lesion, including recurrence of the prominent epithelial component. These features cannot be conclusively ascribed to a variant of either giant cell granuloma, central odontogenic fibroma or aneurysmal bone cyst, but the clinical features are slightly more suggestive of giant cell granuloma. Attention is drawn to the characteristic and potentially confusing histological appearances. The presence of giant cell granuloma-like areas in central odontogenic fibroma-like lesions is associated with an increased risk of recurrence following curettage.

Adolescent↗
PubMed1997

Recurrent peripheral giant cell granuloma associated with cervical resorption.

A case of recurrent peripheral giant cell granuloma in a 38-year-old man is reported. The lesion was localized on the attached gingiva of the lower left second premolar (tooth #35). The surgical excision of the lesion revealed a superficial resorption of the cervical region of the involved tooth. The resorption was smoothed out, and there was no sign of recurrence or further resorption after 14 months. Root resorption, although extremely rare, may be associated with peripheral giant cell granuloma.

Adult↗
PubMed1996

Pleomorphic adenoma of the palate in a child: 9-year follow-up.

Pleomorphic adenoma (PA), the most common of the benign salivary gland tumors, is an extremely rare entity in children before the age of 14 years. Until now, only five cases arising in the palate have been reported in detail. A case of PA of the hard palate in a 10-year-old girl is presented. After a 9-year follow-up period, no recurrence was observed.

Adenoma, Pleomorphic↗
PubMed1995

p53 immunohistochemistry of odontogenic keratocysts in relation to recurrence, basal-cell budding and basal-cell naevus syndrome.

Mutation of the p53 tumour suppressor gene can produce a more stable protein that does not inhibit mitosis, accumulates in the nucleus and can then be detected immunohistochemically in many human tumours using antibody CM-1. The protein has also been detected in odontogenic keratocysts. Routinely processed material from 30 odontogenic keratocysts was immunostained with antibody CM-1. Ten were recurrences and five were associated with the basal-cell naevus syndrome (Gorlin-Goltz syndrome). p53 protein was found in 50% (15/30) of the odontogenic keratocysts, in 53.3% (8/15) of non-recurrent cysts, in 40% (4/10) of recurrent cysts and in 60% (3/5) of those associated with the basal-cell naevus syndrome. Staining was weak and speckled and limited to occasional basal and suprabasal cells. There was no statistically significant difference in staining between these groups and no correlation between expression and the presence of satellite cysts, basal-cell budding or islands of odontogenic epithelium. The low levels of expression may represent physiological expression of wild-type p53 protein rather than mutant or complexed p53 protein.

Antibodies↗
PubMed1995

An unusual intraosseous melanoma in the maxillary alveolus.

A case is reported of a 31-year-old white man who presented with a solitary melanoma in the maxillary alveolus. The lesion was located between and had displaced the roots of the lateral incisor and canine and was relatively well circumscribed on radiography. No mucosal origin or potential primary lesion was found, and a marginal excision resulted in the patient remaining free from disease after 7 years of follow-up. Metastasis of melanoma to the jaws is rare even in disseminated disease, and this solitary lesion is unusual. Although metastasis from a regressed primary tumor cannot be excluded, some of the features raise the possibility that this melanoma may have arisen as a primary tumor within bone.

Adult↗
PubMed1995

Immunohistochemical characterisation of odontogenic cysts with mesenchymal and myofilament markers.

The aim of the present investigation was to analyse the fibroblast phenotype in the main groups of odontogenic cysts. We have examined the muscle differentiation markers alpha-smooth muscle actin (ASMA) and desmin and the presence of vimentin using immunocytochemistry. Fibroblasts of other cyst types, hyperplastic fibrous lesions, and from several normal sites were used as controls. All fibroblasts stained for vimentin, but a variable proportion of cyst wall fibroblasts were also positive for the antibody to ASMA. Their distribution was not random and two positive zones could be distinguished, an inner subepithelial layer and an outer region adjacent to the bone-facing surface. This staining pattern was observed for all the types of odontogenic cysts studied, although the subepithelial staining was more frequent in the presence of an inflammatory infiltrate. The contractile nature of these cells was supported by their ultrastructural appearance. Some non-odontogenic cysts showed subepithelial fibroblasts strongly labelled with ASMA; in the control tissues ASMA was negative except for pericytes and some groups of cells in supracrestal gingiva. These results demonstrate a distinct cell population with a myofibroblast phenotype in the odontogenic cyst wall and with a distribution which may enable them to contribute to wall elasticity constraining cyst expansion. Their presence in all types of odontogenic cyst studied would suggest that myofibroblast formation is independent of the pattern of cyst growth.

Actin Cytoskeleton↗
PubMed1995

Ectopic third molar in the maxillary sinus. Case report.

Ectopic eruption of teeth can occur in a wide variety of sites. These include the mandibular condyle, coronoid process, palate, nasal cavity and maxillary sinus. While this process is unusual, the detection of a third molar in the maxillary antrum is extremely rare. A case is presented of ectopic eruption of a third molar in the left maxillary sinus of a 35-year-old caucasian male giving rise to local morbidity.

Adult↗
PubMed1995

S100, alpha-smooth muscle actin and cytokeratin 19 immunohistochemistry in odontogenic and soft tissue myxomas.

AIMS: To compare the expression of S100 protein, alpha-smooth muscle actin (alpha-SMA) and keratin 19 in odontogenic myxomas and non-odontogenic myxoid lesions. METHODS: Formalin fixed, paraffin wax embedded tissue from seven odontogenic myxomas, three soft tissue myxomas, six hyperplastic myxoid dental follicles, two intramuscular myxomas, 12 cardiac myxomas, and seven normal dental follicles were examined immunocytochemically for S100 protein, alpha-SMA and cytokeratin 19 using the Streptavidin-biotin method. RESULTS: A minority of odontogenic myxomas (three of seven) were positive for S100 and the staining was of moderate intensity and in all myxofibroblasts. Soft tissue myxomas, normal dental follicles, intramuscular myxomas, and most enlarged myxoid follicles were negative. In the cardiac myxomas the cells forming cords and islands were positive in approximately half (seven of 12), but the dispersed stellate myxoblasts were positive in only two cases. A population of cells in all the odontogenic myxomas and hyperplastic dental follicles contained alpha-SMA, but such cells were sparse in cardiac myxomas and present in only four cases. Cytokeratin 19 was present in odontogenic epithelium of odontogenic myxoma and follicles. CONCLUSIONS: A minority of odontogenic myxomas, but not other oral myxoid lesions, may express S100 protein and this could cause difficulty distinguishing myxoma from myxoid nerve sheath tumours. Sparse myofibroblastic cells occurred in all types of myxoma tested. The epithelium sometimes found within jaw myxomas expresses cytokeratin 19 and this is consistent with an odontogenic origin.

Actins↗
PubMed1995

Submandibular sialolithiasis with concurrent sialoadenitis in a child.

Sialolithiasis is a relatively common condition in adults, but it is rarely observed in children. We report a case in a 7-year-old child with a sialolith in the anterior right Wharton's duct resulting in a submandibular sialoadenitis. Under local anesthesia the calculus was removed by means of a sialodochotomy. Post-operative recovery was uneventful and follow-up examinations showed recovery of the function of the affected gland.

Child↗
PubMed1994

Symptomatic foreign body reaction to haemostatic alginate.

Kaltostat, a haemostatic wound dressing made from non-woven sodium calcium alginate fibres is becoming more frequently and widely used by practitioners. We report a florid foreign body giant cell reaction elicited by Kaltostat which had been used to obtain haemostasis in an apicectomy cavity on an upper lateral incisor approximately 7 months earlier. The case demonstrates that alginate fibres left in situ may elicit a long-lasting and symptomatic adverse foreign body reaction. This material should be reserved for problematic haemorrhage and be removed from the tooth socket soon after haemostasis.

Alginates↗
PubMed1994

Immunohistochemical detection of S-100 protein in human deciduous dental pulp.

S-100 protein was investigated in the temporary dental pulp by the immunoperoxidase technique, using the avidin-biotin complex method. The results showed that there was a strong positive reaction in the Schwann cells ensheathing axons and nerve fibers. The other cells within the pulp were immuno-negative. S-100 protein and the results of the present study are discussed.

Cuspid↗
PubMed1994

Spindle cell lipoma of the oral cavity: report of a case.

A true lipoma is an uncommon lesion intraorally and the spindle cell variant is extremely rare, with only four cases reported in the English language literature. A new case of spindle cell lipoma affecting the tongue of a 68-year old white woman is reported.

Aged↗
PubMed1993

Eosinophilic ulceration of the oral mucosa. A case report.

Chronic ulcerative lesions affecting the maxillary vestibular mucosa and the lower labial mucosa of a white female patient are described. Histopathologic examinations indicated a diagnosis of eosinophilic ulceration. Clinical aspects, pathogenesis, and histopathology of this uncommon lesion are discussed.

Diagnosis, Differential↗
PubMed1993

Langerhans cells: structure, function and role in oral pathological conditions.

Langerhans cells (LCs) are dendritic bone marrow derived cells situated suprabasally in most stratified squamous epithelia, such as the epidermis and the epithelium of oral mucosa, including the gingiva. Langerhans cells are thought to act as antigen-presenting cells (APC) during induction of immune responses. The exact role of Langerhans cells in the oral mucosa is not fully understood although several investigations suggest that these cells are involved in reactions to antigen challenge under both normal and pathological situations. In this paper the structure, phenotypic markers and derivation of Langerhans cells are reviewed. In view of recent findings, the immunological characteristics and the implications of Langerhans cells in pathologic oral reactions are discussed.

Antigens, Surface↗