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Biomedical subjects

T Lind

Publications and source records attributed to T Lind.

At least 163 records · Page 9Linked to original sources
PubMed1982

Effect of iron supplementation on serum ferritin levels during and after pregnancy.

Serum ferritin, total plasma ferritin and haematological indices were determined during and for 6 months after normal pregnancy in 45 healthy women, 21 of whom took oral iron supplements. The physiological effect of pregnancy was to markedly depress serum ferritin concentration. During unsupplemented pregnancy median serum ferritin concentration decreased to approx. 6.0 micrograms/l by 28 weeks gestation, this concentration was maintained until term and was associated with the appearance of erythrocyte microcytosis during the third trimester. At 6 months postpartum, individual and average serum and total plasma ferritin values showed a deficit compared with the values recorded at the beginning of pregnancy. Oral iron supplementation during pregnancy modified the fall in serum ferritin, median serum ferritin concentrations remained about 14.0 micrograms/l after 28 weeks gestation; normocytic erythropoiesis was maintained throughout the third trimester and no deficit in serum and total plasma ferritin occurred as a result of pregnancy. It is concluded that routine oral iron administration should be recommended during pregnancy, certainly after 28 weeks gestation.

Adult↗
PubMed1982

The effect of different anticholinergics on the gastric acid response to sham feeding in man.

Modified sham feeding by the chew and spit technique stimulates gastric acid secretion at a level about 50% of peak acid output. This response is vagal and can be totally blocked by vagotomy. The effect on the acid response to modified sham feeding produced by a quaternary amine, benzilonium bromide, and a presumably more selectively acting antimuscarinic drug, pirenzepine, was compared. The drugs were given 45 min and 10 min before the start of the sham feeding, respectively. Benzilonium bromide, 1 + 1 mg, blocked 73% of the acid response to sham feeding and pirenzepine, 10 + 10 mg, blocked 48% of the response. The difference was not statistically significant. The data confirm that a part, about one third, of the acid response to sham feeding is non-cholinergic, although it is vagal.

Adult↗
PubMed1981

Antenatal screening for diabetes mellitus by random blood glucose sampling.

A system is described for screening an antenatal population for diabetes mellitus based upon random blood glucose sampling. Samples obtained from 186 healthy pregnant women at 28 weeks gestation provided a range of blood glucose concentrations after normal meals from which it was possible to derive two glucose values to define an upper limit of normality. The first, 6.4 mmol/l if within two hours of eating and the second, 5.8 mmol/l when taken more than two hours postprandial were prospectively applied to the screening of 763 consecutive antenatal patients. Ten women exceeding these limits were referred for an oral glucose tolerance test and three were found to have a diabetic response, an incidence of about four undiagnosed diabetic women per 1000 antenatal population.

Adolescent↗
PubMed1981

Puerperal haematological indices.

Haematological indices were studied serially in 33 healthy women, at one week before delivery, during the first six days of the puerperium, at six weeks and six months post partum. Red cell count, haemoglobin concentration and haematocrit decreased during the first four days of the puerperium; haemoglobin concentrations up to 3.5 g/dl less than pre-delivery values were recorded in the absence of clinical postpartum haemorrhage. The second puerperal day haemoglobin concentration correlates most closely with the six week postpartum value. A leucocytosis of greater than 20 X 10(9)/1 was found on the first puerperal day in 15 per cent of the women studied.

Erythrocyte Count↗
PubMed1981

Maintained fertility in a patient with hyperprolactinemia due to big, big prolactin.

The heterogeneity of serum PRL in a hyperprolactinemic but fertile woman (Patient A) was studied by gel chromatography. Ninety percent of her PRL eluted with the void volume as "big, big" PRL and only 6% coincided with monomeric "little" PRL. Sera from a woman who had hyperprolactinemia associated with infertility (Patient B) and a normal woman (Patient C) exhibited the usual heterogeneous distribution, where 5% and 19%, respectively, eluted as big, big PRL and 76% and 65%, respectively, eluted as little PRL. Serial dilutions of the serum from Patient A displayed nonparallelism to the lines obtained from similar dilutions of both PRL standard and serum from a normal woman, suggesting possible immunological differences among the three forms of the circulating hormone. This finding, together with reports that suggest big, big PRL has a low receptor affinity, may account for the apparent lack of any biological effect upon Patient A from her sustained hyperprolactinemia.

Adult↗
PubMed1980

Serum equilin, oestrone, and oestradiol levels in postmenopausal women receiving conjugated equine oestrogens ('Premarin').

Two groups of postmenopausal women were seen at monthly intervals during a 6-month trial of cyclic therapy with conjugated equine oestrogens ('Premarin'). the seven women in the first group were taking premarin alone and the six women in the second group were taking premarin plus a progestagen, norethisterone acetate. On each visit, serum unconjugated oestrogens were measured by radioimmunoassay. Mean concentrations for the first group were 393 (+/- 203, SD) pmol/l for 17 beta-oestradiol, 599 (+/- 180) pmol/l for oestrone, and 6840 (+/- 5130) pmol/l for equilin. Corresponding levels for the second group were 342 (+/- 112) pmol/l, 564 (+/- 279) pmol/l, and 8840 (+/- 4020) pmol/l. 3 months after completion of therapy, the oestrone and 17 beta-oestradiol concentrations had returned to pre-treatment levels in both groups, but equilin was detected in 3 out of 3 women in the first group at a mean level of 532 (+/- 267) pmol/l and in 2 out of 4 women in the second group at 1170 (+/- 870) pmol/l. In view of the prolonged presence of equilin and the possible association between treatment with conjugated equine oestrogens and endometrial cancer, it is suggested that equilin-containing compounds should not be given for more than 12 months.

17-Ketosteroids↗