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Biomedical subjects

T Levine

Publications and source records attributed to T Levine.

23 records · Page 2Linked to original sources
PubMed1994

Anterior buccal mandibular depression (ABMD). Anatomic and histologic features.

The anterior buccal mandibular depression (ABMD) is a bilateral symmetrical depression located anterior to the mental foramen and extends under the alveoli of the first premolar to the central incisor. The prevalence, dimensions and contents of the ABMD in cadavers of fetuses and adult modern humans were evaluated. ABMD was found in all fetuses and in 31.8% of adults. The average dimensions of the ABMD in adults were depth 2.36 mm, width 5.44 mm and length 12.43 mm. The present study contributes to a better evaluation of the differential diagnosis and treatment planning in the anterior region of the mandible. A possible etiology for the development of ABMD is suggested.

Aged↗
PubMed1992

Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E.

Proteolytic degradation (processing) of antigen by antigen-presenting cells is a major regulatory step in the activation of a T lymphocyte immune response. However, the enzymes responsible for antigen processing remain largely undefined. In this study we show that cathepsin E, and not the ubiquitous lysosomal cathepsin D, is the major aspartic proteinase in a murine antigen-presenting cell line, A20. This enzyme is localized to a non-lysosomal compartment of the endosomal system in these cells. Functional studies using a highly specific inhibitor of cathepsin E show that this enzyme is essential for the processing of ovalbumin by this cell line. Thus, cathepsin E, whose function was hitherto unknown, may play a major role in antigen processing.

Animals↗
PubMed1990

Recurrent solitary metastasis of renal cell carcinoma in skeletal muscles.

Metastatic carcinoma to skeletal muscle is uncommon and may originate from breast, colon, lung, pancreas and other sources. Recurrent solitary metastases of renal cell carcinoma in the biceps femori and gluteus muscles are described in a 69 year-old man. The tendency of metastases to occur merely in muscles could not be explained in our case. The relative immunity of muscle to the metastatic process should be further investigated.

Aged↗
PubMedDate not supplied

Malignant fibrous histiocytoma of the breast.

Primary Malignant Fibrous Histiocytoma (M.F.H.) of the breast proper is a very rare tumour. From the limited number of cases reported so far (22 including the present one), it seems that a rather high rate of local recurrence and lung metastasis might be expected, and that there is still uncertainty as to the most adequate treatment of the tumour. Therefore, the need for regional node dissection appears justified and we describe herein a case treated by breast quadrantectomy and axillary lymph node dissection.

Breast Neoplasms↗