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Biomedical subjects

T Lerut

Publications and source records attributed to T Lerut.

At least 109 records · Page 6Linked to original sources
PubMed1985

Thromboembolic complications and haemostatic changes in cyclosporin-treated cadaveric kidney allograft recipients.

The incidence of thromboembolic complications was compared retrospectively in 90 cadaveric kidney allograft recipients treated with cyclosporin and low-dose steroids and the same number of cadaveric kidney allograft recipients treated with azathioprine, antilymphocyte globulin, and high-dose steroids. In the cyclosporin group, 17 thromboembolic complications occurred in 13 patients: 10 pulmonary emboli, 1 renal vein thrombosis, 3 deep vein thromboses, and 3 haemorrhoidal thromboses. In the azathioprine group, the only thromboembolic complication was 1 episode of superficial thrombophlebitis. Haemostatic tests in cyclosporin-treated and azathioprine-treated patients and normal subjects (10 in each group) showed increased concentrations of factor VIII C, fibrinogen, antithrombin III, and protein C in the cyclosporin-treated patients. Adenosine-5'-diphosphate-induced platelet aggregation was also significantly enhanced in the cyclosporin group. The effect of cyclosporin on haemostasis may predispose to thromboembolic complications.

Azathioprine↗
PubMed1983

Importance of HLA-DR matching in polytransfused cadaveric kidney transplant recipients. A prospective one-center study.

Since August 1978 prospective HLA-DR typing has been performed in 157 donor-recipient pairs. All recipients received pretransplant blood transfusions. This study shows that HLA-DR matching can significantly improve the survival of cadaveric kidney allografts, even in polytransfused recipients. Patients receiving kidneys with no HLA-DR incompatibilities have a one-year graft survival of 97%, versus 86% for recipients with 1 HLA-DR incompatibility and 73% for recipients with 2 HLA-DR incompatibilities. The cumulative dose of corticosteroids during the first year after transplantation is significantly lower in patients with no DR-incompatibilities. HLA-A and B matching have no additional effect on graft survival.

Adult↗
PubMed1980

Lymphatic complications in renal transplantation.

Lymphocele and lymphatic fistulae are relatively benign complications in renal transplantation. The incidence in our series of 248 renal transplants was 8%. The origin and pathogenesis of lymph collection and augmented lymph flow are discussed. The main importance of this complication lies in its differential diagnosis with urinary fistula and acute rejection episode or deep phlebothrombosis with all its therapeutic implications. Important lymph accumulations should be drained. We prefer as initial treatment a percutaneous closed aspiration which most successfully solves the problem. In case this method should fail, one can choose between external or internal drainage. As in literature, we actually prefer an internal marsupialisation, but completed by an omentoplasty if the leakage originates from the kidney.

Adolescent↗
PubMed1978

Cross-circulation studies on the influence of hypoxia and hypoxaemia on neuro-epithelial bodies in young rabbits.

The reactions of the previously described neuro-epithelial bodies (NEB)(Lauweryns et al., 1969, 1970, 1972a, b, 1973a, b, c 1974, 1975) in young rabbits to: (1) hypoxia with normoxaemia in the arteria pulmonalis on the one hand, and (2) hypoxaemia in the arteria pulmonalis with normoxic aeration on the other hand, has been investigated by means of cross-circulation experiments and light microscopical, electron microscopical and morphometrical techniques. Hypoxically aerated young rabbits, which received normoxaemic blood in their arteria pulmonalis from a donor rabbit by means of an arterio-arterial cross-circulation with mutal exchange transfusion, revealed an increased exocytosis of the dense-core vesicles of their NEB. Normoxically aerated young rabbits which received hypoxaemic blood in an identical manner, did not exhibit an increased exocytosis. It is concluded that the NEB apparently react directly to the hypoxia of the inhaled air and not to the hypoxaemia of the pulmonary blood. By the release of serotonin and a polypeptide substance, they may produce a local vasoconstriction in hypoxically aerated lung areas, enabling an intrapulmonary regulation of the V/Q ratio. This is regarded as additional proof that the NEB--while being modulated by the CNS--probably are intrapulmonary chemoreceptors with local secretory activities, reacting to the composition of the inhaled air.

Animals↗
PubMed1975

[Post-traumatic bronchial stenosis (author's transl)].

The authors have performed plastic reconstruction of a bronchus in a 16 years old patient, 6 1/2 weeks after rupture of the right stem bronchus. This had occurred during a blunt trauma to the thorax. In the acute phase the patient appeared completely cured by suction of the pneumothorax. Later occlusion of the bronchus with total atelectasis appeared. Respiratory function tests, blood gas analyses and pulmonary scintigrams were performed before and 12 weeks after the operation. The authors discuss the data from the literature pertaining to traumatic rupture of the bronchus in its acute phase and during progressive stenosis, for which surgery is warranted. Repair of the stenotic bronchus will make the lungs capable of assuming satisfactory hematosis.

Adolescent↗