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Biomedical subjects

T Lehtonen

Publications and source records attributed to T Lehtonen.

At least 19 recordsLinked to original sources
PubMed1992

Scandinavian clinical study of finasteride in the treatment of benign prostatic hyperplasia.

The effects of finasteride, a potent 5 alpha-reductase inhibitor, were assessed in patients with benign prostatic hyperplasia. Patients were treated with finasteride or placebo for 24 weeks in a double-blind multicenter study followed by a 12-month open-extension period. After 24 weeks, finasteride-treated patients, when compared to placebo-treated patients, showed a significant reduction in prostate volume (22.5% median decrease) and prostate significant antigen (32.4% median decrease), a significant increase in maximum urinary flow (1.6 ml/s mean increase from baseline) and a significant improvement in their obstructive symptom scores (two-point decrease from baseline). Finasteride was well tolerated, and the improvements in prostate volume, maximum urinary flow rate and obstructive symptom scores observed in the controlled study were maintained throughout the extension study.

5-alpha Reductase Inhibitors↗
PubMed1991

Localized amyloidosis of the urinary bladder.

Localized amyloidosis of the urinary bladder is a rare condition. Five patients, 1 with localized secondary amyloidosis, are described. The symptoms, macroscopic hematuria and tumor-like appearance in cystoscopy, may mimic bladder cancer. Diagnosis is based on histopathological examinations with Congo red staining. In most instances, the treatment of choice is transurethral resection and electrocoagulation. Because of the risk of recurrences, a close follow-up is recommended.

Aged↗
PubMed1991

Fibroepithelial polyps of the ureter.

Two cases of ureteric fibroepithelial polyps are presented. Macroscopic haematuria and flank pain were seen as symptoms in both cases. Intravenous urography, retrograde ureteropyelography, computed tomography, and ureterorenoscopy with visual biopsies were used as diagnostic methods. As a result of the preoperative diagnostics, saving surgical procedures (local excision and coagulation of the base of the tumour) were used with good results. The therapy of ureteric tumours should always be founded on the preoperative histological diagnosis and should be conservative transureteric or open surgical.

Adult↗
PubMed1991

Intramural ureteric injury due to acute dilatation.

The effect of balloon dilatation of the ureteric orifice and the intramural ureter was evaluated histologically and radiologically in eight piglets. The distal part of the ureter was dilated from its normal calibre of 4F to 12F. Four weeks after the procedure obvious histological signs due to the preceding dilatation were seen in seven of the eight ureters. In simultaneous radiological studies two ureters showed massive and one slight dilatation and two ureters showed vesicoureteral reflux. The results suggest cautious use of dilatation. Small calibre ureterscopes without ureteric dilatation should be preferred.

Animals↗
PubMed1991

Results of the management of ureteric stones with the ureterorenoscope.

Eighty ureterorenoscopies (URS) were performed for stone removal in 67 patients between January 1985 and April 1988. The success rates for stone removal were 54% in the lower third of the ureter, 70% in the middle third, 38% in the upper third, and 33% in the renal pelvis. The overall success rate was 42%. Open ureterolithotomy was performed after failed ureteroscopy nine times. There were two perforations of the ureter: one by the hook of the forceps and the other by the dormia basket. No significant late complications occurred in 51 patients after six to 36 months postoperatively. At the moment ureteroscopy is of value particularly in the treatment of lower or middle ureteric stones.

Adult↗
PubMed1979

Benign ureteric polyp. Report of a case.

A rare case of benign ureteric polyp simulating ureteric stone in its clinical course is reported. Tumour pathology and treatment of benign ureteric tumours are discussed in relation of literature on the subject.

Adult↗
PubMed1979

Intravesical formalin instillation in the treatment of massive haematuria.

16 patients with massive haematuria due to bladder cancer or cytostatic or radiation cystitis have been treated with intravesical instillation of 4% formalin solution. The method proved to be effective in the control of bleeding in 15 cases, but produced complications two of which were severe. This mode of treatment should thus be limited to debilatated patients in whom other conservative methods fail to control the bleeding. Complications and mode of action of formalin instillation are discussed.

Aged↗
PubMed1978

Active specific immunotherapy of advanced renal-cell carcinoma.

The results of a specific active immunotherapy method following palliative nephrectomy in 31 patients suffering from advanced renal-cell carcinoma are presented. The control patient group comprised of 23 comparable cases, who did not receive immunotherapy. The minimum follow-up time for any patient is 4 years. The statistical 5-year survival rate of the immunotherapy group is 23.6% (SE = 7.8). 7 patients are still alive. The 5-year survival rate of the control group is 4.3% (SE = 4.3), without a single survival. The difference is statistically highly significant (p less than 0.001). No side effects were noted from this form of immunotherapy.

Adenocarcinoma↗
PubMed1978

A comparative study of Kystosol and glycine as irrigating solutions during transurethral prostatic resection.

The author has compared Kystosol and glycine as irrigating solutions during transurethral prostatic resection. Astrum analyses during the operations revealed the development of acidosis in half of the patients in the Kystosol group, whereas in the glycine group, only 4 out of 27 developed a slight decline of base excess. Development of acidosis was directly proportional to the volume of irrigation fluid used and the duration of the operation.

Acetates↗
PubMed1975

Vasectomy for voluntary male sterilisation.

Vasectomy was performed in 90 men in Department of Surgery II of the University Central Hospital of Helsinki during the period January 1st, 1972 to December 31st, 1973. Operation was performed on an ambulatory basis under local anesthesia. After resection and ligation of vas deferens the cut ends were placed in different fascial planes in order to avoid recanalisation. The patients were mainly in the age group 31-40 years. Seven patients had postoperative complications, scrotal hematoma being the most common. Recanalisation was found in one patient, in whom a new operation was performed. The author stresses the importance of a correct vasectomy method, histological verification of the divided vasa and most of all the postoperative sperm analysis. Two negative sperm analyses with an interval of at least 1 month must be recorded before sterility can be confirmed.

Adult↗
PubMed1975

Pulmonary function in tetraplegic and paraplegic patients.

Dynamic spirometry and arterial blood gas analyses were performed in a series of 12 tetraplegic and 8 paraplegic patients. A marked restrictive impairment of ventilatory function was found in all patients with tetraplegia, the mean vital capacity (VC) and one second forced expiratory volume (FEV1.0) were less than half of the predicted normal values. Paraplegia was accompanied only by a slight ventilatory restriction in five patients, while three showed normal respiratory function. Signs of airways obstruction were not revealed in either group. Arterial oxygen tension was normal in all patients. With one exception, elevated PaCO2 values were not found in the series. Hyperventilation (decreased arterial PCO2) was a common finding, it was regarded to be partly due to the effects connected with the examination procedure.

Adolescent↗