Pathomorphology of the intestinal mucosa in diarrheic calves.
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Biomedical subjects
Publications and source records attributed to T Landsverk.
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The patho-morphological alterations in porcine intestinal adenomatosis were studied by light- and electron microscopy, and the pathogenetic mechanisms leading to the adenomatous lesions were discussed. The intestinal changes were partly interpreted as degenerative modifications, partly as hyperplastic processes. In some areas there seemed to be an uncontrolled proliferation of poorly differentiated crypt epithelium, resulting in adenomatous changes. These lesions were associated with intracellular location of bacteria. It was assumed that the epithelial hyperplasia in areas with normal differentiation of crypt cells was an expression of a regenerative reaction. It was further assumed that the faulty regeneration of intestinal mucosa occurred in areas where the mesenchymal destruction was too advanced to allow complete morphological restoration.
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A generalized enlargement of the lymph nodes was found in an emaciated adult ewe. Additional autopsy findings included tiny grey-white necrotic foci in the heart muscle, aspiration pneumonia and diffuse pleuritis. Light microscopy showed a generalized lymphadenopathy with perilymphadenitis, depletion of lymphocytes and histiocytosis of the lymph node. In histiocytes and vascular endothelial cells of lymph nodes, septal capillary endothelium of lungs and capillary endothelium of myocardium, early stages of a protozoan parasite were found. In the myocardium, there were many foci of necrosis, some of which contained young cysts in the periphery. These cysts were morphogically similar tho those of Sarcocystis. Electron microscopy of the early protozoan stages yielded evidence of schizogony and formation of merozoites.
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