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Biomedical subjects

T Laine

Publications and source records attributed to T Laine.

At least 73 records · Page 4Linked to original sources
PubMed1986

Size of the alveolar arch of the mandible in relation to that of the maxilla in 45,X females.

Length and width of the alveolar arch of the mandible and maxilla were determined from hard stone casts of 45,X females (Turner syndrome), female first-degree relatives, and population control females. Adjusted mean values (covariance adjusted for age, previous orthodontic treatment, and number of lost permanent teeth) for mandibular arch width were larger in 45,X females than in normal controls, both absolutely and, more clearly, in relation to the maxillary arch. The total absolute length of the mandibular arch was slightly reduced in 45,X females. The broader and shorter alveolar arch of the mandible in relation to the narrower but normal-length maxillary arch reflects imbalanced facial growth in subjects with one X-chromosome instead of the normal two.

Adult↗
PubMed1986

Occlusal morphology in 45,X females.

Seventy-two 45,X females (Turner syndrome) were examined for occlusal anomalies. Prevalence comparisons were made with first-degree female relatives and female population controls. The method of Björk et al [1964] was used for determination of malocclusion. The results clearly suggest an increased prevalence of occlusal anomalies in 45,X females. The most common malocclusions are cross bite, large maxillary overjet, distal molar occlusion, and a tendency to open bite. These anomalies reflect an imbalanced growth of the craniofacial skeleton in three dimensions. These findings suggest that genes on the human X chromosome are of importance in the harmonious growth and development of the craniofacial skeleton and ultimately normal occlusal morphology and relations.

Adolescent↗
PubMed1985

Nonsuppression of cortisol in depression and immune function.

Eighteen depressive patients and twenty-five healthy control subjects were studied using a comprehensive immunological test system and the dexamethasone suppression test (DST) as well as some additional neuroendocrine parameters. In addition, immune functions of six of the patients were studied serially three times at 1-2 month's intervals. The OKT 4+/8+ ratio (OKT 4+ = helper/inducer phenotype; OKT 8+ = suppressor/cytotoxic phenotype) was slightly higher in those ten depressive patients showing suppression in the DST than in healthy controls, but there were no significant differences between the nonsuppressor and suppressor groups or between the nonsuppressor and suppressor groups or between nonsuppressors and control subjects. Lymphocyte transformation responses induced by phytohaemagglutinin (PHA) were similar in the nonsuppressors and suppressors, but lower in both groups than in control subjects. The number of Ig-secreting cells measured in the absence and presence of pokeweed mitogen (PWM) were similar in the nonsuppressor and suppressor groups. Four of the depressive patients tested repeatedly exhibited an abnormal response in the DST at the beginning of the study. During the follow-up period two of them recovered completely from depression as well as the patients with a normal suppression in the DST. The proportions of T and B lymphocytes and regulatory T lymphocyte subsets as well as the functions of T and B lymphocytes of the nonsuppressors and suppressors in the DST were within normal ranges before and after recovery from depression and comparable to healthy controls in repeated testing. The results indicate that in spite of the importance of cortisol in immunoregulation, the increased cortisol secretion and typical resistance to dexamethasone suppression in endogenously depressive patients is not profoundly and consistently reflected in immune functions. Neither does normalization of cortisol responses induce any major changes in immune status during a patient's recovery from depression. Previous work indicates that suppressed immunity may play an important role in the increased morbidity and mortality associated with bereavement. In the light of present findings we suggest that endogenous depression differs also in this respect from grief reactions.

Adult↗
PubMed1985

Space anomalies, missing permanent teeth and orthodontic treatment.

Statistical association of crowding and spacing with age, sex, orthodontic treatment and extractions finds a tendency for more maxillary posterior spacing in males and more lower anterior spacing in females. Extractions were also associated with spacing. No association was found between spacing and orthodontic treatment.

Adult↗
PubMed1985

Palatal dimensions in 45,X-females.

Seventy-two females with 45,X-chromosome complement were examined for palatal dimensions, and the results of the measurements were compared to those of first-degree normal female relatives of the study subjects and population control females. Hard stone casts were prepared for measuring widths and lengths of the maxillary alveolar arch and palatal height between or at the level of the permanent canines, first and second premolars, and first molars with a palatometer and sharp-pointed vernier calipers (0.5 mm). According to the analyses of covariance (history of orthodontic treatment and loss of permanent teeth as cofactors and age as covariate), the differences in palatal dimensions between the groups were statistically significant or highly significant for all dimensions except for palatal height in the posterior segments. The group of the 45,X-females had the highest mean value for palatal height at the level of the canines and systematically the lowest mean values for palatal width in all segments, while no clear difference could be found in the length of the alveolar arch between the 45,X-females and the relatives, the population control group showing the lowest value in the posterior segments. The findings of this study indicate that the narrowed palate rather than the high palate is a frequent but not definite feature in 45,X-females. This may reflect the effect of sex-chromosomes on width but not other dimensions of the palate, resulting in deficiency of transversal growth of the palate possibly through decreased growth of the palatal shelves or through disturbances in the growth of the nasal septum, sutural growth, or--to which the exostosis on the palatal alveolar plates would refer--disturbances in apposition-resorption growth changes of the maxilla.

Adolescent↗
PubMed1982

Cross-sectional study of orthodontic treatment and missing of permanent teeth in two birth cohorts of Finnish students according to sex.

Undergraduate students (n = 451) at a Finnish university were studied. For analysis, the subjects were divided into two birth cohorts: those born before 1955, and those born in that year or later. Information about previous orthodontic appliance therapy was obtained from the students by using a structured questionnaire. Missing permanent teeth (second and third molars excluded) were recorded at a dental examination. Every 10th student had received orthodontic treatment; the proportion of orthodontically treated subjects was higher for females (14%) than for males (5%). Seven percent of students born in 1954 or earlier and 15% of the younger students had had orthodontic treatment before 1977. In 39% of subjects, at least one permanent tooth was missing while only 12% had lost more than two permanent teeth. The tooth missing most often was the permanent mandibular first molar (in 23% of subjects). Frequency of tooth loss was the same in males and females. At least one permanent tooth was missing in 48% of the older and in 31% of the younger students. At least one first molar had been lost by 36% of the older students and 20% of the younger ones. Fewer first molars but more permanent teeth anterior to the first molars were missing in subjects who had had orthodontic treatment than in subjects who had not had such treatment. Among Finnish students the frequency of extraction of permanent teeth because of caries is decreasing, and the frequency of orthodontic treatment is increasing. Females are more likely to seek orthodontic treatment than males are.

Adult↗
PubMed1979

Dihydralazine therapy and acetylator phenotype.

The acetylator phenotype was studied in 21 hypertensive patients receiving chronic treatment with dihydralazine and other antihypertensive drugs. Plasma dihydralazine concentrations were measured 6 hours after the morning dose of the drug. There were no significant differences between the slow and fast acetylators 1) in the daily dose of dihydralazine needed, 2) in the concentrations of dihydralazine achieved in plasma, 3) in the dose/concentration-relationship of dihydralazine or 4) in the appearance of side effects. Antinuclear antibodies were found in five patients. Four of them were fast acetylators. The lowest dose/concentration relationship was found in a patient with impaired renal function. According to these results the acetylator phenotype seems to be an unimportant factor in therapy with dihydralazine. More investigation will be needed in order to elucidate the metabolism of dihydralazine.

Acetylation↗