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Biomedical subjects

T L Sarkin

Publications and source records attributed to T L Sarkin.

12 recordsLinked to original sources

The origin and evolution of vertebrate pattern and form--a theory of vertebrate development by preformation based on the genetic molecular shape.

A new hypothesis is presented to explain the origin of vertebrate form and the guiding mechanism by which embryological development occurs. The hypothesis is based on the observation which is demonstrated, that both vertebrate form and embryological development follow a pattern which correlates with the shapes formed by a spiral as it unfolds. The fact that the DNA molecule which carries the genetic information for embryological development, also has a helical structure, has suggested the hypothesis, that vertebrate form and its development are related to the molecular shape of the genetic material. A theoretical vertebrate genetic molecular structure is proposed and it is demonstrated how this structure by "unfolding", as growth occurs, (the mechanism for which is suggested) provides an accurate prepattern and a template for vertebrate embryological development and vertebrate form. Evolutionary implications follow, which question the Neo-Darwinian synthesis. These are firstly, that the vertebrate pattern is not the result of random genetic variations and natural selection, but owes its origin to a spiral pattern, possibly that of DNA. Secondly, that progressive changes occurring in the shape of the genetic molecule provide an explanation and a mechanism for the evolution of species; a concept which is demonstrated.

Animals

Backache in the aged.

Backache is a treatable condition in most geriatric patients. A detailed history, a careful clinical examination, an X-ray examination and determination of the sedimentation rate usually enable one to categorize the discomfort as a "mechanical syndrome" or as a "pathological syndrome" of back pain. The former indicates that the tissues of the back are essentially normal but are displaced or strained, while the latter indicates an infiltration of the tissues by a pathological process. The important conditions causing backache in elderly patients in these two groups are listed and their treatment is discussed.

Aged

Osteo-arthritis of the trapeziometacarpal joint.

A review of a group of 87 patients with osteo-arthritis of the trapeziometacarpal joint is presented and the results of treatment by non-surgical means and by excision of the trapezium, by arthrodesis of the trapeziometacrapal joint and by prosthetic replacement are reviewed. Indications and contra-indications to surgery, as revealed by this series, and the type of operation best carried out in individual cases, are discussed. The common association of a median carpal tunnel syndrome, which should receive prior treatment, is emphasised.

Aged