Biomedical subjects

T L Phillips

Publications and source records attributed to T L Phillips.

At least 235 records · Page 13Linked to original sources

PubMed1976

Radiotherapy for verrucous carcinoma.

Radiotherapy of verrucous carcinoma has frequently been associated with anaplastic transformation and poor response. No anaplastic transformation was observed in the 6 patients receiving radiotherapy as the primary treatment, and control of disease was favorable compared with 5 surgically treated patients. Four of the 6 undergoing radiotherapy are alive NED 1-4 years later. Review of the literature and of the University of California cases fails to substantiate an increase in anaplastic transformation in in verrucous carcinoma patients. We recommend that verrucous carcinoma be treated as other squamous cell carcinomas of similar sites and stages.

Carcinoma, Papillary↗

PubMed1976

Palliation for carcinoma of the esophagus.

From 1950 to 1973, 169 patients received irradiation for esophageal squamous cell carcinoma. The average survival time was 10 months, with 7% of the patients living 2 years or more. The median survival time was 7 months; palliation averaged 6 months. Most completing therapy (89%) achieved some palliation: 66% had significant relief of dysphagia for 2 months or longer. The anatomical location of the malignant obstruction did not influence therapeutic response; there was similar response in cases of upper, middle, and lower esophageal lesions. Thirty patients with progressive obstruction underwent endoesophageal intubation with Celestin tube placement; this procedure provided symptomatic relief with minimal morbidity.

Adult↗

PubMed1976

External and interstitial radiation therapy of carcinoma of the oral tongue. A review of 32 years' experience.

In 204 patients with squamous cell carcinoma of the oral tongue treated with radiation therapy, the most significant prognostic factors appeared to be the presence of neck lymph node metastasis on presentation and the status of the disease three months after treatment. The most common site of failure was the primary lesion, either alone or with neck disease. External irradiation alone was seldom successful. Use of peroral cone irradiation or interstitial implants, either alone or in combination with external irradiation, achieved good local control in early lesions. When the primary tumor was uncontrolled by radiation therapy, salvage with surgery was rare. When failure occurred in the neck alone, radical neck dissection was successful in the majority of cases.

Adolescent↗

PubMed1975

Elevated IGA in carcinoma of the nasopharynx.

Fourteen patients with nasopharyngeal carcinoma were evaluated immunologically prior to standard radiotion therapy. All had elevations of serum IgA, ranging from 300 mg/100 ml to 1000 mg/100 ml, with a mean value of 549 mg/100 ml. Seven patients demonstrated depression of cell-mediated immunity as measured by delayed hypersensitivity skin tests, total lymphocyte count, in vitro stimulation with PHA, and T-cell rosette formation. Elevation of serum IgA associated with depression of cell mediated immunity may be characteristic of patients with nasopharyngeal carcinoma.

Antibody Formation↗

PubMed1975

Radiation tolerance of the spinal cord.

A series of nine cases of radiation myelopathy seen at the University of California, San Francisco (UCSF) is reviewed, and their treatment data converted into nominal single doses (NSD) and equivalent single doses (ED). The 1% incidence level of myelopathy in the thoracic cord is 1015 rets (ED), and the 50% incidence level is 1476rets (ED). Caution should be used when utilizing a rapid fractionation schedule; it appears that 2000 rads in 5 fractions and 3000 rads in 10 fractions is a safe regimen for the thoracic spinal cord.

Dose-Response Relationship, Radiation↗

PubMed1975

Modification of radiation injury to normal tissues by chemotherapeutic agents.

The effects of several cancer chemotherapeutic agents on radiation damage to normal intestine, esophagus, and lung tissue were evaluated in LAF 1 mice using quantitative endpoints. In all tissues tested, actinomycin D increased injury and BCNU did not. In the intestine, adriamycin enhanced radiation damage more than any other agent. Bleomycin increased damage in the esophagus but not in the lung or intestine. Cyclophosphamide increased injury only in the lung, where vincristine caused minimal injury, and hydroxyurea, none. Only prednisolone caused significant radioprotection when given at the time of irradiation or at the time of expected death from pulmonary injury.

Animals↗

PubMed1975

Nature of the multiple forms of sweet-potato glucose phosphate isomerase.

The previously reported isoenzymes of sweet-potato glucose 6-phosphate isomerase were resolved by DEAE-cellulose chromatography. The multiple forms exhibited identical electrophoretic properties and electrofocused as a single component with an apparent isoelectric pH of 4.0. Chromatographic studies also suggest that the multiple forms do not represent true isoenzymes.

Glucose-6-Phosphate Isomerase↗

PubMed1975

Tumor and normal tissue response to irradiation in vivo: variation with decreasing dose rates.

Continuous irradiation in vivo at dose rates ranging form 0.54 to 274 rads per minute was performed in mice using the EMT6 tumor, the gut clone system, and the bone-marrow CFU system. A progressive increase in D0 and decrease in ñ were seen with decreasing dose rates in the EMT6 tumor and the gut clone system. The D0 showed little change in the bone-marrow CFU system. These findings are related to the D2-D1 values obtained from split-dose experiments at conventional dose rates. The results do not fit the various mathematical models proposed for correlating the effects of continuous low-dose-rate irradiation and acute exposure.

Animals↗

PubMed1975

Serum IgA in the diagnosis of nasopharyngeal and paranasal sinus carcinoma.

The serum immunoglobulin-A level was elevated in patients with nasopharyngeal carcinoma (mean 526 plus or minus 188 mg/100 ml) and paranasal sinus carcinoma (mean 451 plus or minus 124 mg/100 ml) prior to radiation therapy. After treatment, the IgA levels were lower in nasopharyngeal carcinoma patients. Elevated serum IgA values were also noted in patients with recurrent nasopharyngeal carcinoma. Serum IgA determinations may be useful as an additional diagnostic test for squamous cell carcinoma of the nasal and oropharynx.

Carcinoma, Squamous Cell↗

PubMed1975

Treatment of locally recurrent carcinoma of the nasopharynx.

Forty-two patients with recurrent nasopharyngeal carcinoma in the primary site and/or neck nodes were treated at the University of California, San Francisco, between 1940 and 1974. Sixty-nine per cent of the recurrences appeared within 3 years and 83% within 5 years after initial treatment. Retreatment included external radiotherapy and/or intercavitary radium or cobalt beads in the majority of cases. The actuarial survival rate was 41% at 5 years after first recurrence. Survival rates increased proportionally with increasing time between initial treatment and recurrence. There was no statistically significant difference in survival rates with respect to age, sex, race, or histology. Local soft-tissue or bone necrosis developed in 9 patients, but both conditions were tolerated well.

Adult↗

PubMed1975