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Biomedical subjects

T L Green

Publications and source records attributed to T L Green.

35 records · Page 2Linked to original sources
PubMed1987

Human papillomavirus type 2 DNA in oral and labial verruca vulgaris.

Twenty instances of verruca vulgaris, equally divided between oral mucosa and lip vermillion, were assayed for the presence of human papillomavirus (HPV) capsid antigen and type-specific DNA employing in situ hybridization methods. All 10 cases arising on lip vermillon expressed capsid antigen and harbored HPV Type 2 genomes as assessed under conditions of high stringency DNA hybridization. Oral verrucae rarely expressed capsid antigen; HPV Type 2 genomes were encountered in 20% of the cases.

Antigens, Viral↗
PubMed1987

Evaluation of the Ca 1 monoclonal antibody in distinguishing oral squamous cell carcinoma from non-malignant or premalignant oral lesions.

The Ca antigen has been reported to be present on the surface of malignant but not, with few exceptions, non-malignant cells. We investigated the potential usefulness of the monoclonal Ca 1 antibody in differentiating oral squamous cell carcinoma from non-malignant or premalignant oral neoplasms. Paraffin-embedded sections from 33 biopsy specimens of 12 hyperplastic and 21 neoplastic oral lesions were examined by immunohistochemical staining. Seven of the 33 specimens showed positive staining for Ca antigen. Fifteen of 21 specimens of oral squamous cell carcinoma were negative for Ca antigen, and one case of focal keratosis was positive. The results indicate that the use of the Ca 1 antibody to distinguish oral squamous cell carcinoma from non-malignant or premalignant oral lesions is highly unreliable.

Antibodies↗
PubMed1986

Oral melanoma: report of case.

A case is presented of a patient whose death might have been prevented if the dentist had been aware of the malignant potential of a benign-appearing oral mucosa pigmentation. Early recognition, diagnosis, and treatment of pigmented oral lesions are emphasized.

Diagnosis, Differential↗
PubMed1984

Histopathologic spectrum of oral Kaposi's sarcoma.

There has been a striking increase in the incidence of oral Kaposi's sarcoma in association with acquired immunodeficiency syndrome (AIDS). Oral lesions are seen in approximately 50% of AIDS patients with Kaposi's sarcoma. Lesions may appear as a flat or raised pigmented area, often resembling a benign vascular lesion, and are commonly found on the palate. Useful histopathologic criteria for the recognition and diagnosis of oral Kaposi's sarcoma include (1) atypical vascular channels (especially in early lesions), (2) a prominent spindle cell component in later lesions, (3) extravasated red blood cells, (4) hemosiderin, (5) the presence of eosinophilic bodies, (6) chronic inflammatory cells in early lesions, and (7) mitotic figures in tumor-stage lesions.

Acquired Immunodeficiency Syndrome↗
PubMed1980

Oral warty dyskeratoma.

Warty dyskeratoma (isolated dyskeratosis follicularis) is generally thought of as a cutaneous lesion of the head and neck regions. A small number of cases have been reported in the oral mucosa, usually overlying the alveolar ridge or the palate. The present case exhibits both clinical and histologic features which are consistent with the previously reported cases.

Aged↗
PubMed1980

Arrangement of integrated avian sarcoma virus DNA sequences within the cellular genomes of transformed and revertant mammalian cells.

We have examined the arrangement of integrated avian sarcoma virus (ASV) DNA sequences in several different avian sarcoma virus transformed mammalian cell lines, in independently isolated clones of avian sarcoma virus transformed rat liver cells, and in morphologically normal revertants of avian sarcoma virus transformed rat embryo cells. By using restriction endonuclease digestion, agarose gel electrophoresis, Southern blotting, and hybridization with labeled avian sarcoma virus complementary DNA probes, we have compared the restriction enzyme cleavage maps of integrated viral DNA and adjacent cellular DNA sequences in four different mouse and rat cell lines transformed with either Bratislava 77 or Schmidt-Ruppin strains of avian sarcoma virus. The results of these experiments indicated that the integrated viral DNA resided at a different site within the host cell genome in each transformed cell line. A similar analysis of several independently derived clones of Schmidt-Ruppin transformed rat liver cells also revealed that each clone contained a unique cellular site for the integration of proviral DNA. Examination of several morphologically normal revertants and spontaneous retransformants of Schmidt-Ruppin transformed rat embryo cells revealed that the internal arrangement and cellular integration site of viral DNA sequences was identical with that of the transformed parent cell line. The loss of the transformed phenotype in these revertant cell lines, therefore, does not appear to be the result of rearrangement or deletions either within the viral genome or in adjacent cellular DNA sequences. The data presented support a model for ASV proviral DNA integration in which recombination can occur at multiple sites within the mammalian cell genome. The integration and maintenance of at least one complete copy of the viral genome appear to be required for continuous expression of the transformed phenotype in mammalian cells.

Animals↗
PubMedDate not supplied

Clear cell odontogenic tumor--a new histologic variant with aggressive potential.

This report delineates the clinical and laboratory findings for a previously unreported neoplasm of putative odontogenic origin. We describe the clinical, radiographic, operative, histologic, histochemical, and ultrastructural findings of the tumor in three women. All lesions were centrally located in the jaw bones, were expansile, and, except for mobile teeth and/or jaw enlargement, exhibited few symptoms. Radiographically, there was bone and tooth destruction resulting in poorly delineated margins. Microscopically, the tumors were nearly identical in that they consisted primarily of large sheets and islands of uniform vacuolated and clear cells without evidence of amyloid deposition, calcification, or glandular differentiation. One of the lesions recurred 1 1/2 years after removal without evidence of metastasis. The results, based only on these cases, suggest that this is a locally aggressive neoplasm of odontogenic origin. Casual microscopic examination of this rare neoplasm could result in misdiagnosis as a metastatic clear cell neoplasm, especially renal cell carcinoma.

Aged↗