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Biomedical subjects

T Kuyama

Publications and source records attributed to T Kuyama.

At least 37 records · Page 2Linked to original sources
PubMed1988

Coexisting adenocarcinoma and malignant lymphoma of the stomach: case report and review of the Japanese literature.

After a diagnosis of advanced carcinoma, a 77-yr-old female underwent gastrectomy. A 6 X 5 cm ulcerative mass in the angle was shown to be differentiated adenocarcinoma in the surrounding wall, and malignant lymphoma in the bottom. Carcinomatous infiltration was limited to the muscularis mucosae. Neither generalized lymphoma nor locoregional lymph node metastasis of either neoplasm was noted. A survey of 35 Japanese patients, including our own case with the two coexistent neoplasms in the stomach, revealed that the male-to-female ratio was 2.3:1, with no significant difference between the mean age of the sexes. The prevalence of adenocarcinoma in its early stage (60% of 35 patients) and of a histologically differentiated type (85% of 27 patients) of adenocarcinoma is quite different from that of usual Japanese gastric carcinoma, and it may suggest that there are some factors influencing the coexistent development of both neoplasms.

Adenocarcinoma↗
PubMed1988

[Clinical studies on various therapy for the intractable trauma of toes and fingers in cases of diabetes mellitus and peripheral ischemic diseases].

In cases of ischemic extremities and diabetes mellitus, the trauma on finger and toe is very intractable. For such injuries amputation of extremity is indicated very often because of severe necrosis. The number of such cases has been increasing recently because many cases of these patients have arteriosclerotic arterial occlusion and diabetes mellitus, and these are correlated with the changes of aging. The number of cases of Buerger's disease has been also increasing and it is another etiology of intractable trauma in ischemic extremity. The repeated hyperbaric oxygenation, sympathetic block, warfarin therapy and insulin bath with bubbling of hyperbaric oxygen, were applied to has been of such necrosis. By these procedures, the rate of amputation of extremity decreasing. It was concluded that the surgical reconstruction of artery for ischemic extremity has never any meaning as the therapy of such intractable injuries, if blood flow in the peripheral tissue is not kept physiologically, before vascular reconstruction. In order to increase peripheral tissue circulation, the hyperbaric oxygenation, sympathetic block and warfarin therapy wer performed in many cases and these methods were very effective for intractable injuries with severe necrosis.

Adult↗
PubMed1986

[Structural and hormonal alterations in the pancreas after hepatectona in dogs].

Humoral factors in the portal blood have often been suggested to play an important role in hepatic regeneration after hepatectomy. However, the correlation among insulin, glucagon and somatostatin, and islet cells of Langerhans has not been studied. Forty percent hepatectomy was carried out in dogs and intravenous glucose administration (0.5 g/kg) was the function of the pancreas to release one week after and one month after surgery to estimate administered intravenously before surgery, the plasma insulin, glucagon and somatostatin. In addition, islet cells of Langerhans were investigated with PAP technique. The following results were obtained. Alterations of carbohydrate metabolism developed as a result of portal plasma insulin deficiency one week after surgery, but granules in B cells were demonstrated as much as preoperatively. It was suggested that hypersomatostatinemia suppressed insulin release from B cells. Alterations of carbohydrate metabolism was restored to normal and portal plasma insulin response was increased one month after surgery. These indicate that hepatic regeneration after hepatectomy may contribute to these changes. Islets cell of Langerhans were hypertrophic and particularly, D cells were increased after surgery.

Animals↗
PubMed1986

Immunohistochemical changes of the islet cells of Langerhans after partial hepatectomy in dogs.

Morphological changes were studied in the islet cells of Langerhans after hepatic resection in dogs. The animals were laparotomized before and 1 wk and 1 month after partial hepatectomy. Pancreatic tissue was taken and immediately immersed in neutral formalin and then stained with PAP. One hundred visual fields were examined microscopically. One month postoperatively there was 4- to 5-fold hypertrophy of the islets of Langerhans (486 +/- 23 micrometers 2 before to 2236 +/- 98 micrometers 2 1 month after operation) (p less than 0.01). A, B, and D cells were also found to be increased in number. D cells, especially, showed mitotic division and proliferation, and the ratio of the number of D cells pre-, 1 wk post-, and 1 month postoperation was 1:1.37:2.80, showing a gradual increase after operation.

Animals↗
PubMed1986

Plasma gastrin and secretin changes after esophagectomy.

Plasma gastrin levels were determined in 14 patients with esophageal cancer submitted to an esophagogastrectomy. Six patients were also given 0.1 N hydrochloric acid preoperatively and 1 month after operation to clarify the secretion of plasma secretin. In addition, the correlation between the G cell population in the pyloric part of the postoperative intrathoracic stomach and plasma gastrin was investigated, and the following results were obtained. Hypergastrinemia developed 1 month after surgery, but 3 months or more after surgery, the plasma gastrin level was close to normal. Plasma secretin levels tended to fall postoperatively, but no statistical differences in plasma secretin levels could be found. Staining by the enzyme antibody method revealed hyperplasia of G cells in patients with hypergastrinemia without pyloric antral atrophy.

Aged↗