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Biomedical subjects

T Kuribayashi

Publications and source records attributed to T Kuribayashi.

99 records · Page 6Linked to original sources
PubMed1979

[Polyuria and polydipsia in a young boy--a case study (author's transl)].

A 13-year-old boy with a teratoma in the sellar region was presented. This patient had gradually developed polyuria and polydipsia since 2 years prior to the first admission. Endocrinological examination showed a marked reduction of pituitary function. Careful neuroradiological examinations including CT failed to show any mass lesion in the sellar and suprasellar regions but a marked increase of the width of the third ventricle. CSF examination revealed only a slight increase of cell count (lymphocytes). The patient was discharged with hormonal replacement therapy. Seven months later the patient developed visual disturbance and mental disorders. On the second admission, plain skull films showed enlarged sella and CT demonstrated a mass in the suprasellar region. Preoperative diagnosis was suprasellar germinoma. At surgery a teratoma, probably arising from the pituitary fossa, was totally removed. Histopathology of the tumor showed tri-dermal tissues including melanotic progonoma and germinoma. The authors presented various problems of the patient and their solving processes.

Adolescent↗
PubMed1975

[Relation of TRH test to thyroidal suppression test by triiodothyronine in patients with hyperthyroidism under treatment with antithyroid drugs (author's transl)].

The relation of the TRH test to the T3 suppression test was investigated in 43 patients with hyperthyroidism receiving antithyroid drugs for 6 to 27 months (average 14 months). TRH tests were performed by measuring serum TSH levels before and 15, 30, 45, 60, 90 and 120 minutes after intravenous injection of 500 mug of synthetic TRH. Serum TSH was measured by a double antibody radioimmunoassay. Two weeks later, the T3 suppression test was performed by measuring the 24-hr thyroidal uptake of radioiodine after daily administrations of 75 mug of triiodothyronine for 8 days. All patients under study were in euthyroid state, estimated by serum T3-RSU, T4, T3 and FT4I. The value for 24-h uptake after T3 administration was less than 20% in 18 cases, out of which the response to TRH was normal or exaggerated in 15 cases and was absent or impaired in 3 cases. On the other hand, out of 25 cases with the value of 24-h uptake more than 20%, the response to TRH was absent or impaired in 18 cases and was normal or exaggerated in 7 cases. The results of the TRH test and the T3 suppression test were correlated in 33 out of 43 cases. The responsiveness to TRH and the suppressibility with T3 was dissociated in 10 cases, suggesting the TRH test could not replace the T3 suppression test.

Adolescent↗
PubMedDate not supplied

Wegener's granulomatosis (WG) and insulin dependent diabetes mellitus (IDDM).

We report a case of a 14 year-old girl with Wegener's granulomatosis (WG) complicated by its direct brain invasion and insulin dependent diabetes mellitus (IDDM). This case was diagnosed as WG early in its onset and successfully treated. As for IDDM of this case, the presence of HLA-DR4 and the islet cell surface antibody (ICSA) was demonstrated. To our knowledge, this is the first case report on IDDM associated with WG. We consider that WG may precipitate the development of IDDM in a genetically predisposed subject.

Adolescent↗
PubMedDate not supplied

Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in a patient with multiple sclerosis.

Association of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) with multiple sclerosis (MG) is very rare, although many other disorder of the nervous system have been reported to be associated with this syndrome; there is only one case report in the literature. We describe here a patient with the syndrome associated with MS. A 62-year-old women had a variety of neurologic symptoms, where clinical course was typical of MS. Transient episodes of hyponatremia and disturbance of consciousness occurred repeatedly with deterioration of MS. The concentration of antidiuretic hormone (ADH) was high whereas the plasma osmolality was low in the presence of concentrated urine, during the episodes of hyponatremia. Urinary Na excretions exceeded 20 mEq/day. Computed tomography and magnetic resonance imaging revealed lesions in the brain, especially in the periventricular region. The hypothalamus and pituitary appeared normal by these imaging methods. Since the periventricular region surrounds and may be functionally connected to the hypothalamus which plays the central role in the regulation of ADH secretion, it was concluded that association of SIADH and MS in this patient was not coincidental, and that demyelinating processes in the periventricular region exerted an abnormal influence on ADH secretion resulting in SIADH. Contribution of other mechanisms as increased intrathoracic pressure, however, could not be excluded completely.

Cerebral Ventricles↗
PubMedDate not supplied

A case of Graves' disease associated with Klinefelter's syndrome.

Graves' disease was found in a 41-year-old, married male patient with Klinefelter's syndrome. The patient began having finger tremor 5 years previously, and developed palpitation and weight loss 3 months prior to examination. He had a diffuse goiter, exophthalmos, and atrial fibrillation. Plasma levels of T3, T4 and free T4 were 2.8 ng/ml, 16.6 micrograms/dl and 4.5 ng/dl respectively. [123I] uptake was 53%, and TSH receptor antibody was 75%. Although he had no gynecomastia, his general physical appearance was that of typical eunuchoism. Chromosome studies showed a karyotype of 47,XXY. A diagnosis of Graves' disease associated with Klinefelter's syndrome was made.

Adult↗
PubMedDate not supplied

Prognostic factors in stage I and II non-Hodgkin's lymphoma of Waldeyer's ring.

Sixty-nine stage I and II patients treated for non-Hodgkin's lymphoma of Waldeyer's ring were retrospectively analysed. Diffuse histiocytic lymphoma (Rappaport's classification) was the most common histology (67%). Staging without laparotomy revealed 31 patients in stage I and 38 in stage II. Sixty-five patients received radiation therapy against involved or extended fields. In 43 patients adjuvant chemotherapy with single or multiple agents was given and 4 patients received only chemotherapy. A relapse occurred in 34 (49%) patients. The 5-year relapse-free survival was 67 per cent and 36 per cent in stage I and stage II, respectively. Radiation doses of 50 Gy gave no recurrence within treated volumes. However, since relapse below the clavicles and especially below the diaphragm was common, the radiation doses did not seem important for reduction of the overall failure rate. In stage II, patients with a single neck node less than 5 cm in diameter seemed to have a better prognosis than patients with large or multiple neck nodes. In this non-randomized study adjuvant chemotherapy seemed to reduce the risk of relapse, especially in stage II patients.

Adolescent↗