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Biomedical subjects

T Kumazaki

Publications and source records attributed to T Kumazaki.

At least 271 records · Page 15Linked to original sources
PubMed1976

Congenital renal arteriovenous fistula: case report, review of Japanese literature and description of non-radical treatment.

A case of congenital arteriovenous fistula diagnosed by measuring the oxygen saturation difference of renal veins at the time of selective renal angiographic examination and a review of 38 relevant Japanese cases are reported. The English as well as the Japanese literature was reviewed. Treatment has consisted of partial nephrectomy, ligation of the branch artery supplying the fistula and intentional embolization of the arterial branches, feeding the shunt by catheter.

Aged↗
PubMed1976

Affinity chromatography of trypsin and related enzymes. II. An affinity adsorbent containing glycylglycyl-L-arginine.

An affinity adsorbent for trypsin [EC 3.4.21.4] (GGA Sepharose) was prepared. Glycylglycyl-L-arginine (GGA) was synthesized by a simple procedure and was immobilized on agarose gel. This adsorbent proved to have essentially the same characteristics as AP Sepharose, which is an affinity adsorbent containing tryptic peptides of protamine (1). GGS Sepharose was specific for native trypsin and had a stronger affinity at lower pH's (6-5) than at the optimum pH of trypsin action (8.2). It also proved to be suitable for analytical experiments because of its relatively weak affinity. By comparison of the elution profiles of trypsin from GGA Sepharose under various conditions, the nature of the interaction of trypsin with the adsorbent could be studied. It was found that alpha- and beta-trypsin could be distinguished. In the presence of arginine and N-substitute arginines, the elution of trypsin was accelerated. From the extents of the accelerating effects, the affinities of these compouunds could be compared.

Animals↗
PubMedDate not supplied

Examination of protein sequence homologies: I. Eleven Escherichia coli L7/L12-type ribosomal "A" protein sequences from eubacteria and chloroplast.

Seven complete and four partial sequences of Escherichia coli L7/L12-type ribosomal "A" proteins obtained from various bacteria (E. coli, Bacillus subtilis, Micrococcus lysodeikticus, Rhodopseudomonas spheroides, Desulfovibrio vulgaris, Streptomyces griseus, Bacillus stearothermophilus, Clostridium pasteurianum, Arthrobacter glacialis, and Vibrio costicola) and spinach chloroplast have been reexamined using a computer program that searches for homologous tertiary structures. Comparison matrices for the sequences show that they match the sequence of E. coli L7 (EL7) if one assumes the insertion or deletion of certain residues at sites corresponding to residues 1, 38, 49, and 92 of EL7. That two additional insertion points are found only in the spinach chloroplast protein suggests that the chloroplast protein probably diverged from the bacterial forms. Further phylogenetic relationships among these 11 prokaryote-type "A" proteins are discussed with respect to average correlation coefficients computed, taking into account the existence of the gaps.

Amino Acid Sequence↗
PubMedDate not supplied

Detection and characterization of focal liver lesions using superparamagnetic iron oxide-enhanced magnetic resonance imaging: comparison between ferumoxides-enhanced T1-weighted imaging and delayed-phase gadolinium-enhanced T1-weighted imaging.

BACKGROUND: Double contrast magnetic resonance (MR) imaging using superparamagnetic iron oxide (SPIO) and gadolinium (Gd) is performed to detect and characterize focal liver lesions. However, this technique is a costly and lengthy process. The purpose of this study was to determine the usefulness of SPIO-enhanced MR imaging including SPIO-enhanced T1-weighted imaging in diagnosing focal liver lesions. METHODS: Eighty-four focal liver lesions were examined with a 1.5-T MR unit. Transverse precontrast T1- and T2-weighted images and SPIO (ferumoxides)-enhanced T1- and T2-weighted images were obtained, followed by Gd-enhanced T1 -weighted imaging. The Gd set (i.e., precontrast T1- and T2-weighted and delayed-phase gadolinium-enhanced T1-weighted images) and ferumoxides set (i.e., precontrast T1- and ferumoxides-enhanced T1- and T2-weighted images) were reviewed by two independent readers. RESULTS: More lesions were detected from the ferumoxides set than from the Gd set. Ferumoxides-enhanced T1-weighted imaging showed enhancement patterns of the lesions similar to those of delayed-phase Gd-enhanced T1-weighted imaging. The diagnoses of hepatic metastasis and cyst by the ferumoxides set were similar to those by the Gd set. However, a dynamic study may be inevitable for the diagnosis of hepatocellular carcinoma and hemangioma. CONCLUSION: The ferumoxides set was useful for the detection of focal hepatic lesions. Ferumoxides-enhanced T1-weighted imaging may replace delayed-phase gadolinium-enhanced T1-weighted imaging in the diagnosis of hepatic metastasis and cysts.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Retroperitoneal bronchogenic cyst: CT and MR imaging.

Retroperitoneal bronchogenic cysts are extremely rare congenital anomalies that represent malformations of the embryonic foregut and are morphologically expressed as maldevelopments of the respiratory system. Because of the low prevalence of these tumors, their imaging features have seldom been described. We present the computed tomographic and magnetic resonance imaging findings of a case of retroperitoneal bronchogenic cyst.

Adult↗
PubMedDate not supplied

Nonenhanced magnetic resonance imaging of mild acute pancreatitis.

BACKGROUND: Computed tomography (CT) is not always effective for demonstrating mild acute pancreatitis, and the intravenous administration of iodine contrast medium is harmful to the inflamed pancreas. The goal of this study was to evaluate the usefulness of nonenhanced magnetic resonance (MR) imaging for the depiction of mild acute pancreatitis. METHODS: We performed T1-weighted imaging with a short echo time, T2-weighted imaging, and MR cholangiopancreatography (MRCP) in 12 patients with mild acute pancreatitis. Nonenhanced CT and contrast-enhanced CT were always performed before the MR studies. RESULTS: T1- and T2-weighted MR images using a breath-hold or respiratory-triggered technique produced clearer images of the inflamed pancreas than did CT. Peripancreatic fat necrosis was shown by both methods. Although MRCP demonstrated no abnormalities of the pancreatic duct, it demonstrated stones in the gallbladder and common bile duct. CONCLUSIONS: Nonenhanced MR imaging was superior to CT for depiction and confirmation of mild acute pancreatitis.

Acute Disease↗
PubMedDate not supplied

Fat-suppressed gadolinium-enhanced three-dimensional magnetic resonance angiography adequately depicts the status of iliac arteries following atherectomy and stent placement.

Fat-suppressed, three-dimensional magnetic resonance angiography (3D MRA) was performed on nine patients with 11 iliac artery stenoses following atherectomy or stent placement. The MRA accurately depicted continued patency, restenosis, or aneurysm formation when compared with immediate posttreatment conventional arteriography. Therefore MRA is accurate and can be used independently for clinical decision making.

Aged↗
PubMedDate not supplied

Transjugular intrahepatic portosystemic shunt in a patient with cavernomatous portal vein occlusion.

A 23-year-old woman with liver cirrhosis secondary to primary sclerosing cholangitis was referred to us for the treatment of recurrent bleeding from esophageal varices that had been refractory to endoscopic sclerotherapy. Her portal vein was occluded, associated with cavernous transformation. A transjugular intrahepatic portosystemic shunt (TIPS) was performed after a preprocedural three-dimensional computed tomographic angiography evaluation to determine feasibility. The portal vein system was recanalized and portal blood flow increased markedly after TIPS. Esophageal varices disappeared 3 weeks after TIPS. Re-bleeding and hepatic encephalopathy were absent for 3 years after the procedure. We conclude that with adequate preprocedural evaluation, TIPS can be performed safely even in patients with portal vein occlusion associated with cavernous transformation.

Adult↗
PubMedDate not supplied

Case report: serous atrophy of bone marrow and subcutaneous tissue enhancement associated with recurrent rectal carcinoma: MR appearances.

We report a case of serous atrophy of bone marrow associated with recurrent rectal carcinoma detected by MR images. Bone marrow of vault, clivus and femur showed waterlike signal patterns in T1- and T2-weighted images. Postcontrast T1-weighted images revealed no enhancement of bone marrow, while subcutaneous tissue showed decreased signal intensity and enhancement consistent with an increase in connective tissue with fat atrophy. Gadolinium-enhanced MR imaging was useful for differentiating the serous atrophy of marrow from bone metastasis in this carcinoma patient.

Aged↗
PubMedDate not supplied

Development of rotational digital angiography and new cone-beam 3D image: clinical value in vascular lesions.

Despite the rapid improvement of new imaging modalities such as CT, MRI and echography techniques, angiography still plays the role of gold standard for the diagnosis of vascular lesions. The main reason for this dependence on angiography is its superiority in the S/N ratio and spatial resolution. However, the essential problem remained in angiography, even in modern DSA, is that, after a single injection of contrast medium, imaging is done from only one or two projections. Serial filming by rotating method of the X-ray unit around the longitudinal axis of the target organ will theoretically solve the above problem. This method has been documented at times for cerebral angiography since the report of Cornelis et al. [1], while the rotational digital X-ray system sufficient to various human organs has been described by few authors [2,3]. The aim of this paper is to discuss the value of the new system from the clinical view.

Angiography↗