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Biomedical subjects

T Krause

Publications and source records attributed to T Krause.

108 records · Page 6Linked to original sources
PubMed1988

[Scintigraphic findings in myocardial infarct].

Radioisotope studies are currently used mainly to assess the individual risk before and after myocardial infarction. Scintigraphy will be used increasingly to diagnose and localize acute myocardial infarction, to measure the infarct size and to detect reperfusion, whether spontaneous or after lysis, in the infarct area. High sensitivity and specificity are obtained by using tomographic imaging modalities and by the combined and simultaneous use of markers for perfusion and necrosis. This technique allows recognition even of nontransmural infarctions, involvement of the right ventricle, subendocardial necroses, and ischemic injuries in unstable angina pectoris.

Antibodies, Monoclonal↗
PubMed1988

Localization of 99mTc-diphosphonates in newly formed bone matrix as a measure of bone lesion detectability.

The lesion-to-normal-bone ratios of DBA-MDP (dibutylamino-methylene-diphosphonate), DPD (dicarboxypropane-diphosphonate) and MDP (methylene-diphosphonate) each labeled with 99mTc, were evaluated in experimental bone lesions. In 3-day old lesions this ratio was increased twofold for DBA-MDP in comparison with MDP and DPD which showed nearly equal ratios. Later on these differences became negligibly small. It is concluded that 99mTc-DBA-MDP is fixed more strongly in the immature bone matrix and that this will lead to an improvement in the detectability of lesions containing larger amounts of immature bone matrix.

Animals↗
PubMed1987

Evaluation of long-term oral levodopa therapy in chronic congestive heart failure.

To evaluate the long-term effects of orally administered levodopa, 11 patients with chronic congestive heart failure (NYHA III-IV) were studied during maintenance therapy (30 +/- 1 days) and after withdrawal from levodopa. The daily levodopa dose was 4 g in six patients; because of side effects the levodopa dose was reduced to 2-3 g in the remaining patients. After withdrawal of levodopa, mean pulmonary capillary wedge pressure and mean right atrial pressure increased significantly (from 19 +/- 2 to 24 +/- 3 and from 7 +/- 2 to 9 +/- 2 mmHg, respectively). Effective renal plasma flow was 329 +/- 57 during levodopa therapy and decreased significantly to 252 +/- 27 ml/min after withdrawal of levodopa. The number of ventricular premature contractions and couplets increased during levodopa therapy and decreased again significantly after withdrawal of levodopa. No significant differences between on and off levodopa were observed in resting heart rate, arterial blood pressure, cardiac index, stroke work index, systemic vascular resistance, sodium and water excretion, or creatinine clearance. Seven patients improved on levodopa therapy by one NYHA class; four of these seven patients deteriorated again by one NYHA class after withdrawal of levodopa. Regarding both clinical and hemodynamic changes after withdrawal of levodopa, three patients were classified as responders to long-term levodopa therapy. All three responders received 4 g levodopa per day. Average dopamine plasma level was 5.3 +/- 0.8 ng/ml in the responder group and 2.0 +/- 0.5 ng/ml in the nonresponder group. Long-term administration of oral levodopa is associated with beneficial clinical and hemodynamic response in only a minority of patients with chronic congestive heart failure.

Administration, Oral↗
PubMed1987

V-factor dependent strains of Pasteurella multocida subsp. multocida.

At bacteriological examination of swine lungs with pneumoniae due to Mycoplasma hyopneumoniae, two strains of pyridine nucleotide (V-factor) requiring bacteria were isolated. They exhibited a pattern of biochemical reactions fitting with that of Pasteurella multocida subsp. multocida. Deoxyribonucleic acid (DNA): DNA hybridization with these isolates and Pasteurella multocida subsp. multocida showed that they were V-factor requiring strains of this species. Preliminary investigations on the qualitative and quantitative V-factor requirements have been performed.

Animals↗
PubMed1986

Fine needle aspiration cytology and exfoliative biliary cytology in the diagnosis of hilar cholangiocarcinoma.

Nineteen patients with suspected malignant obstruction at the confluence of the bile ducts had exfoliative biliary cytology and fine needle aspiration cytology performed. Of these patients 14 cases were histologically proven to be cholangiocarcinoma, and 3 others followed a clinical course which was clearly malignant. Fine needle aspiration cytology gave a true positive result in 14 patients (87.5%), whereas exfoliative cytology was positive in 11 (73%). There were no false positive results and no complications from either procedure. Both the cytological procedures are rapid and safe and are useful for preoperative planning of surgical and intraoperative diagnosis.

Adenoma, Bile Duct↗
PubMed1986

[Simultaneous 201Tl/99mTC seven-pinhole tomography in acute myocardial infarct].

Combined infarction scintigraphy with 201Tl-chloride and 99mTc-pyrophosphate (PPi) by simultaneous seven-pinhole tomography was investigated with a phantom as well as in patients. No artificial defects occurred when the collimator was centered correctly in axial position, but a very high standard of image uniformity and linearity of the gamma camera was required. Artefacts by overlying activity from the skeleton or cardiac blood pool were not observed. All 11 controls showed normal results. Despite a poor depth resolution due to limitations of the system even small areas of partially damaged myocardium could be recognized and correlated three-dimensionally. Of 24 patients with proven myocardial infarction, in 16 both a positive (99mTc-PPi) and a negative (201Tl) image was obtained in congruence with the necrosis. 8 patients (33%) showed discordant results providing however additional information on the nature and extent of the necrosis. 4 out of 6 non-transmural infarctions seen by tomography had been suspected clinically.

Adult↗
PubMed1984

[Diagnostic and prognostic significance of so-called rheumatoid vasculitis].

23 patients with rheumatoid arthritis and high rheumatic factors (mean titres of rheumatic factors 1 : 1 434) within a prospective study on the diagnostic and prognostic significance of the rheumatoid vasculitis which was performed together with the Research Institute for Rheumatism Moscow underwent examinations for the proof of an extraarticular organ manifestation. In correspondence with the data in literature we found rheumatic nodes (70%) as most frequent extraarticular organ manifestation. In 1 patient each a participation of the lungs and a rheumatic exudate of the pleura, respectively, could be diagnosed. In another patient there were references to a vasculitis at the fundus of the eye. In only 2 patients there was a vasculitis of the digital arteries with necroses, in one of them a generalized vasculitis. 5 of the 13 neurologically examined patients showed polyneuropathic symptoms. Of the biochemical findings the C-reactive protein and the blood sedimentation rate showed clear increases and correlations.

Adolescent↗
PubMed1984

[Acoustically evoked brain stem potential in Wilson disease].

By 48 patients with Wilson's disease the brainstem acoustic evoked potentials were stated. There were 35 pathological findings (73%), 13 were normal (27%). The waves, determined by the middle and upper brainstem (Pons and Mesencephalon) showed most of all pathological changes. Those patients with forms of Wilson's disease called Pseudoskelerose and Pseudoparkinson showed the most pathological findings. But one could watch these findings by about 30% of patients in preclinical stage. This method can possibly be used for early detection of disorders of brainstem functions and in the same way it can be used for control of treatment by patients in preclinical stage.

Adult↗
PubMed1983

[Sporadic occurrence of benign myopathy with early contractures (Emery, Dreifuss and Rotthauwe)].

A myopathy which sporadically appeared in a young male corresponds clinically, electromyographically, histologically and cardiologically to the rare picture of the X-chromosomally recessive benign myopathy with early contractures. The coordination to the clinical picture mentioned and the genetic advice, taking into consideration the X-chromosomally recessive heredity, are discussed and proved.

Adult↗
PubMedDate not supplied

Analysis of myocardial motion based on velocity measurements with a black blood prepared segmented gradient-echo sequence: methodology and applications to normal volunteers and patients.

The paper describes a strategy for measuring and characterizing myocardial motion in terms of velocity parameters derived from measurements with a segmented black blood prepared phase contrast gradient echo sequence. The characteristic parameters are calculated by transforming the velocities measured on a pixel-by-pixel basis across the left ventricle from the laboratory frame of reference into a cylindrical coordinate system, in which the motion velocities within the short axis plane are represented in polar coordinates and which is located at the center of the myocardium and moving with it over the ECG cycle. First results in a study with 12 healthy volunteers gave highly consistent values for the radial (expansion/compression) as well as the rotational velocities. Except for one volunteer, motion at the R wave of the ECG starts with clockwise rotation, followed by contraction and expansion accompanied by counterclockwise rotation. First examinations of patients with global and focal disease demonstrate the potential to detect disturbances in the local as well as the overall motion patterns.

Adult↗
PubMedDate not supplied

Homing of intravenously and intralymphatically injected human dendritic cells generated in vitro from CD34+ hematopoietic progenitor cells.

Dendritic cells (DC) are professional antigen-presenting cells that can be generated in vitro from CD34+ peripheral blood progenitor cells by recombinant cytokines. These cells have potential implications for immunotherapeutic approaches in the treatment of cancer and other diseases. Physiologically, immature DC in the periphery capture and process antigens, then mature to interdigitating DC and migrate to lymphoid organs, where they activate lymphocytes. However, it is not known if DC generated in vitro have the capacity to traffic in vivo to the lymphoid tissues, such as spleen and lymph nodes. We have investigated whether human radiolabeled DC differentiated in vitro migrate and localize to lymphoid tissues after intravenous and intralymphatic injection. The distribution and localization of the DC were evaluated in five patients with malignant melanoma using serial whole-body gamma camera imaging. Intravenously infused DC demonstrated transient lung uptake followed by localization in the spleen and liver for at least 7 days. DC injected into a lymphatic vessel at the dorsal foot were rapidly detected in the draining lymph nodes where they remained for more than 24 h. These data suggest that DC differentiated in vitro localize preferentially to lymphoid tissue, where they could induce specific immune responses.

Antigens, CD34↗
PubMedDate not supplied

Combined thallium 201/technetium 99m-labeled pyrophosphate tomography for identification of the "culprit" vessel in acute myocardial infarction.

BACKGROUND: Many previous investigations have used the presence of transient ischemic 201Tl perfusion defect to localize coronary artery stenosis. This study reports the results of 201Tl tomography alone and combined 201Tl/99mTc-labeled pyrophosphate (99mTc PYP) tomography employed to identify the infarct-related vessel in patients with acute myocardial infarction (AMI). METHODS AND RESULTS: All short-axis images were evaluated by dividing each left ventricular slice into eight equal sectors. In addition, for combined 201Tl/99mTc PYP tomography, two sectors were added to evaluate involvement of the right ventricle. In a preevaluation phase of the study, the sectors were assigned to the supplying coronary arteries in 75 patients with single chronic myocardial infarction related to the left anterior descending coronary artery (LAD), left circumflex artery (LCX), or right coronary artery (RCA). In this pilot phase, 201Tl tomograms were reviewed in conjunction with the angiographic data. This assignment was then tested prospectively in 117 patients with AMI. As confirmed by angiography, the AMI was related to the LAC, LCX, and RCA in 54, 17, and 46 patients, respectively. Sensitivity and specificity for 99mTc PYP accumulation on combined 201Tl/99mTc PYP tomography were 98% a nd 100% for the LAD, 88% and 99% for the LCX, and 98% and 96% for the RCA, respectively. For 201Tl tomography, sensitivity and specificity for identification of the culprit vessel were 94% and 89% for the LAD, 82% and 91% for the LCX, and 72% and 96% for the RCA, respectively. CONCLUSION: This prospective study demonstrates that combined 201Tl/99mTc PYP tomography is highly accurate for identification of the infarct-related artery in AMI, even in patients with multivessel disease. Positive contrast visualization of myocardial necrosis in both the left and right ventricle allows for reliable differentiation between AMI related to the LCX or RCA territory. In comparison, for 201Tl tomography the sensitivity to detect the culprit vessel, particularly the LCX and RCA, appears to be lower than for 201Tl 99mTc PYP imaging, particularly in patients with prior infarction or right dominant coronary artery.

Coronary Vessels↗