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Biomedical subjects

T Krahe

Publications and source records attributed to T Krahe.

At least 73 records · Page 4Linked to original sources
PubMed1988

[Long-term course of chronic polyarthritis under basic drug therapy].

A retrospective analysis was undertaken of 31 patients with classical or proven chronic rheumatoid arthritis (CRA) who had been on a regimen of basic medication (gold salts, D-penicillamine, chloroquine, azathioprine--alone or in combination). Disease activity was checked by clinical, biochemical, immunological and radiological criteria. The laboratory results could not be altered by the basal medication and there was no relationship with the clinical and radiological findings, except for immunological results. None the less, the clinical symptoms improved under basal medication, even though the functional index got worse. The degree of joint destruction at the beginning and end of the observation period was markedly higher for seropositive than sero-negative cases, without significant differences in the rate of progression of joint destruction. Thus, definite long-term remission was achieved regarding the inflammatory changes but not the progressing joint destruction.

Adult↗
PubMed1988

[Value of imaging procedures in the diagnosis and staging of bladder tumors].

A retrospective study of 161 patients with carcinomas of the bladder was carried out to assess the value of CT (247 examinations), transurethral sonography (32 examinations), and the early results of MRT. For TA-T3a staging, according to the TNM classification of the IUCC, transurethral sonography was particularly valuable. CT is useful for demonstrating transmural tumour growth (T3b) and organ invasion (T4), involvement of regional lymph nodes and distant metastases. Tumours in the roof of the bladder and at its base are well shown by MR tomography, using multiplanar sections.

Adult↗
PubMed1988

[MR tomography of the temporomandibular joint using T1-weighted multislice-gradient echo-sequences].

31 examinations of temporo-mandibular joints, using T1-weighted multislice gradient echo sequences have been performed. The short scan time of one minute and 50 seconds ensured that there were no movement artefacts in 28 cases. The position of the disc was visible in more than 90% of examinations. Degenerative changes in the cartilage and arthroses of the joint cannot be demonstrated adequately by the rapid sequences.

Adult↗
PubMed1988

[Echo morphology of testicular tumors].

The ultrasound and histological findings of 130 testicular tumours were compared; these included 56 seminomas, 49 teratomas, 16 mixed tumours, five Leydig cell tumours, three lymphomas and one metastasis. There was only a slight tendency to low echo homogeneous structure with seminomas and low echo irregular structure with teratomas and mixed tumours. Cystic components, or strongly echogenic structures, were found in 20 to 30% of primary testicular malignant tumours, but these findings were non-specific. Cystic lesions were found at histology to be due to necroses, haemorrhage or specific tumour cysts. Strongly echogenic appearances correlated with calcification, fibrosis or bone or cartilage development. There were no specific sonographic criteria suitable for the identification of specific tumour types.

Adult↗
PubMed1988

[Hemangioma of the liver: often an incidental finding].

Hemangioma is the most frequent benign liver tumor with an incidence of 0.4-7.3%. The tumors are typically small, asymptomatic and detected accidentally by ultrasound or CT. Hemangiomas extending a diameter of 2-3 cm can be proved by dynamic contrast CT or scintigraphy with 99-m Tc erythrocytes. Hemangiomas with a diameter less than 2 cm are a diagnostic dilemma. In case of a typical ultrasonic picture (small white tumor) in an asymptomatic patient, a consequent ultrasonic follow-up is indicated. It is yet unclear whether MRI will be an additional diagnostic tool to identify small hemangiomas.

Hemangioma↗
PubMed1987

[Cardiomyopathy in idiopathic hemochromatosis. Diagnostic possibilities using proton spin tomography].

In idiopathic hemochromatosis, there is progressive deposition of iron in parenchymatous organs owing to a defect in iron absorption the nature of which is not so far known. This can result in cardiomyopathy with heart failure and arrhythmia which are refractory to therapy. Nuclear magnetic resonance tomography is a specific imaging technique for early detection of myocardial iron deposits. With quantitative determination of the T2 relaxation time of the myocardium, a progress control under venesection therapy is possible above and beyond diagnostics.

Bradycardia↗
PubMed1987

[Cardiac MRT. Research technic and topographic anatomical imaging information].

ECG-triggered cardio-MRT, using T1-weighted SE sequences, provides images of the heart showing very high anatomical resolution. So far, however, it has not been possible to demonstrate the morphology of the valves and coronary vessels. By using multiplanar sections, it is possible to obtain cuts which are perpendicular to the portion of myocardium or valve under consideration. This provides optimal imaging for morphological diagnosis and for evaluating the ventricular myocardium and its function.

Coronary Vessels↗
PubMed1987

[Magnetic resonance tomography (MRT) of the orbit].

By using high field strengths and surface coils, MRT achieves a resolution comparable with CT in the orbita. The advantages of MRT are good contrast resolution and imaging in several planes. Twenty-six patients have been examined by MRT, which has shown high sensitivity and good detail for the demonstration of pathological changes. In spite of this, MRT at present is not a realistic alternative to ultrasound and CT, because it is unable to demonstrate bone and calcification; its specificity is low, but the time and cost of the examination is high. It is indicated only for problems involving the optic nerve and chiasma.

Adolescent↗
PubMed1987

[Magnetic resonance tomography (MRT) of the adrenals].

Thirty-eight MRT examinations were carried out in 35 patients who, between them, had 19 abnormalities in the adrenal glands. These included ten adenomas, three metastases, two carcinomas, two phaeochromocytomas, and two primary retroperitoneal tumours. MRT provides images of normal and abnormal adrenal glands which are equivalent to those of CT, with the exception that it cannot demonstrate calcification. Using a ratio of signal intensity from the adrenal tumours and the liver on T2-weighted images, it is usually possible to differentiate adenomas from metastases, carcinomas or phaeochromocytomas. The increased specificity of MRT is valuable in the investigation of patients with asymptomatic enlargement of the adrenal glands.

Adrenal Gland Neoplasms↗
PubMed1987

[Computed tomographic research on the viability of a free fat pedicle flap in the area of a laminectomy].

Nineteen patients were examined clinically and by CT three to five years after partial or total hemilaminectomy using a fat pedicle as cover. The results were compared with a control group of fourteen patients without fat pedicles. With CT it is possible to check the fat pedicles directly. Survival of the fat pedicle without peridural scarring was present in 68%. It was not possible to demonstrate any correlation between the extent of scarring and clinical abnormalities.

Adipose Tissue↗
PubMed1987

[Rapid MR tomography of the liver. Technic and initial results].

The fast-field-echo (FFE) sequence provides a new rapid imaging method for MR tomography. By using gradient echoes with shorter high frequency pulse repetitions than conventional sequences with 180 degrees echo pulses, it is possible to produce single cuts in 10 to 20 s with good signal-to-noise ratio. In this way the liver can be examined while respiratory movement artifacts are reduced. The possibility of obtaining T1- and T 2-weighted FFE images with good contrast resolution and the ability to determine relaxation times suggests a wide application of this rapid imaging procedure in the diagnosis of liver disease.

Carcinoma, Hepatocellular↗
PubMed1987

[Computed tomography and angiography in aortic dissection].

The authors report on 32 patients with dissecting aneurysm examined via computed tomography, 21 of whom were also additionally examined by means of angiography. Whereas CT with contrast medium bolus resulted in a diagnosis in dissecting aneurysm in all the cases, aortography failed in 2 patients because of a thrombosed dissection. Aortography offers clear advantages over CT, besides better spatial representation, in respect of clarification as to which aortic branches are involved, especially in the region of the aortic arch. On the other hand, the advantages of CT are lower invasiveness, high sensibility and the possibility of including concomitant complications when establishing the diagnosis.

Aortic Dissection↗
PubMed1987

[Follow-up study in chronic polyarthritis as represented in roentgen image].

Thirty-one patients with chronic polyarthritis under medical treatment had x-rays of their hands performed at the beginning of the illness and after seven years, on average. The findings were compared with clinical and biochemical data. Despite treatment, there was marked progression in the periarticular destructive changes, although the clinical features had improved. The extent of periarticular destruction was significantly greater amongst seropositive than amongst seronegative patients, both at the beginning and the end of the study, but there was no significant difference in the rate at which this progressed. It was not possible to demonstrate a statistically significant correlation between the radiological appearance of the joints and the clinical and laboratory findings.

Adult↗
PubMed1987

[MR tomography of Kallmann's syndrome].

MR tomography is the only imaging method that can demonstrate atrophy of the olfactory lobe of the brain in olfacto-genital dysplasia (Kallmann's syndrome). The MRT findings in five patients with Kallmann's syndrome are described. The MRT criterion for the presence of Kallmann's syndrome appears to be an interruption or total absence of the olfactory sulcus.

Adult↗
PubMed1987

[MR tomography in the control of chemonucleolytic therapy].

MR tomography can be used for the diagnosis of lumbar disc prolapse and provide information concerning the indications and the follow-up of injection treatment with chymopapain. It is able to distinguish various parts of the disc from their varying signal intensity. Examination of 26 patients showed the effect of chymopapain on intradiscal fluid shift based on shifts in signal intensity. The use of T2-weighted gradient echo sequences over a period of seven to ten minutes is sufficient to show significant changes in the disc following chemonucleolysis.

Female↗
PubMed1987

[Computed tomography of primary and secondary tumors of the eye and orbit].

Only computed tomography (CT) is able to demonstrate ocular, orbital and peri-orbital soft tissues, calcification and bony structures directly and without superimposition of other tissues. 165 patients with tumours of the eye or orbit have been examined by CT and in 143 the diagnosis has been confirmed. The value of CT lies in its ability to demonstrate tumours and to define their orbital and extra-orbital extension and their relationship to neighbouring structures. In 51% of the lesions there was bone destruction and in 6% intracranial extension. Density measurements before and after intravenous contrast medium only rarely provided a specific diagnosis.

Adolescent↗
PubMed1987

[MR tomography in lymphatic and leukemic bone marrow infiltrations. A comparison with scintigraphy and conventional x-ray diagnosis].

MR is the only noninvasive procedure that can demonstrate changes in the medullary space. If it is combined with bone marrow scintigraphy and conventional x-ray film diagnostics, it can yield a comprehensive diagnosis of bone marrow infiltrations in the regions of the pelvis, thighs and lumbar vertebral column in leukaemia or malignant lymphomas. The T1 relaxation times of the malignant infiltrations are enhanced compared with normal fatty marrow. MR tomography of the bone marrow is particularly suitable for determining the therapy or follow-up control of a malignant systemic disease.

Bone Marrow↗