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Biomedical subjects

T Koike

Publications and source records attributed to T Koike.

At least 757 records · Page 42Linked to original sources
PubMed1983

Computed tomographic demonstration of the effect of proximal parent artery ligation for giant intracranial aneurysms.

Four patients with giant intracranial aneurysms, which measured over 2.5 cm in diameter, were treated by ligation of the proximal parent artery. The location of the aneurysms were intracavernous in two patients, paraophthalmic in one patient, and vertebral in the other patient. The effect of ligation was followed by repeated computed tomography scans with angiographic correlation. The aneurysms thrombosed soon after ligation, and with time, gradually organized with a reversal of the mass effect. Five years after the ligation, one aneurysm thrombosed completely and lost its mass effect upon the adjacent structures. For giant aneurysms treated with ligation of the proximal parent artery, computed tomography scans are a useful method for continuing review, producing precise information concerning actual size, thrombus formation, and various pathological changes.

Adult↗
PubMed1983

Methylprednisolone pulse therapy in dermatomyositis.

A high dose of methylprednisolone (pulse therapy) was given to 3 patients with uncontrolled dermatomyositis (DM) accompanied by severe muscle weakness. The effects of pulse therapy were compared with findings in 5 patients with severe DM who were treated with the usual dose of prednisolone (controls). The pulse therapy led to an improvement in the clinical symptoms in the 3 patients with uncontrolled DM, who were in danger of aspiration pneumonia. A rapid reduction in muscle enzyme levels in this group was also evident.

Adolescent↗
PubMed1982

Specificity of mouse hybridoma antibodies to DNA.

Utilizing the somatic cell hybridization technique, we established 12 clones of mouse hybridoma from MRL/Mp-lpr/lpr(MRL/1) and NZB X NZW(B/W F1) mice, which produce antibodies reacting mainly with ssDNA (anti-ssDNA) and 2 clones from B/W F1 mice, which produce antibodies reacting with both ssDNA and dsDNA (anti-ss/dsDNA). By means of a competitive inhibition radioimmunoassay with synthetic polynucleotides, the anti-ssDNA antibodies were classified into 5 types, in terms of the DNA base specificity. The anti-ss/dsDNA antibodies had polyspecific reactivity to a wide range of polynucleotides, including synthetic RNA.

Animals↗
PubMed1982

Subpopulation of T cells sensitive to natural thymocytotoxic autoantibody (NTA) of New Zealand mice. I. Distinct cytotoxic sensitivity of functional T cell subsets to NTA and anti-thy-1 antibodies.

NZB mice produce a natural thymocytotoxic autoantibody (NTA) capable of specifically injuring thymocytes and T cells. NTA-reactive antigen (NTA-A) shows a different density distribution among T cells, and partial killing with NTA and complement can eliminate T cells bearing NTA-A in high density. Thy-1 antigen is similar to NTA-A in this respect. To determine the effects of NTA and anti-Thy-1 on distinct functional subsets of T cells, Con A-induced suppressor T cell (Con A-Ts) activity against the allogeneic mixed lymphocyte reaction (MLR), responding T cell (TMLR) activity in the allogeneic MLR, and Con A-induced cytotoxic T cell (Con A-Tc) activity were examined simultaneously in BALB/c spleen cells before and after partial elimination of NTA- and anti-Thy-1-sensitive T cells. Treatment with NTA and complement resulted in a marked reduction in Con A-Ts activity, a significant increase in TMLR-activity and a slight and inconstant decrease in Con A-Tc activity. Since Con A-generated T's were much less sensitive to NTA, the NTA-sensitive T cells involved in Con A-Ts activity appear to be precursors or promoters of the Con A-Ts. In contrast, the precursors of Con A-Tc seem to relatively resistant to NTA. The increase in TMLR activity caused by NTA suggests the possibility that NTA is less cytotoxic for TMLR and cytotoxic for some suppressor T cells in allogeneic MLR. The monoclonal anti-Thy-1 antibody showed no such preferential cytotoxic effects on the three T cell functions. The NTA-sensitive T cells, in contrast to anti-Thy-1-sensitive T cells, were reduced gradually during Con A stimulation. All these findings indicate that NTA-A not only differs from Thy-1 antigen but that it appears to be a unique T cell antigen.

Animals↗
PubMed1982

[Therapeutic results of DCMP therapy (2M-80) in acute non-lymphocytic leukemia--the relationship between the residual leukemic cells and duration of remission].

In this study the duration of complete remission by daunomycin, cytosine arabinoside (Ara-C), 6MP and prednisolone (DCMP) therapy using a large dose of Ara-C (200 mg) (protocol 2M-80) was compared with that of DCMP therapy with a low dose of Ara-C (80-160 mg) in acute non-lymphocytic leukemia (ANLL). In protocol 2M-80, the chemotherapy was continued until leukemic blasts in marrow were attained below 3%. Complete remission was induced in about 80% of ANLL patients in both chemotherapies. However, the duration of remission in protocol 2M-80 appeared to be much longer than that of DCMP therapy with a low, dose of Ara-C. This difference was dependent not on the consolidation and maintenance therapy, but on the total dose of Ara-C used and leukemic blasts left in marrow at the end of chemotherapy. This suggests that it is important to reduce leukemic blasts in marrow as low as possible by induction chemotherapy to obtain a long-term remission in ANLL.

Acute Disease↗