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Biomedical subjects

T Koide

Publications and source records attributed to T Koide.

At least 253 records · Page 14Linked to original sources
PubMed1989

[Effect of fluoride releasing composite resin on bovine enamel].

FluorEver is one kind of fluoride releasing composite resin. The first aim of this study was to investigate the amount of fluoride released from FluorEver. The second aim of this study was to determine the uptake of fluoride with bovine enamel, which was immersed in distilled water for 28 days in contact with FluorEver, compared with Fuji Ionomer cement which released fluoride. The results obtained were as follows. 1) A great amount of fluoride was released from FluorEver immediately after immersion. Twenty-four hours after immersion, the amount of released fluoride decreased quickly. From the 3rd day of immersion, the amount of fluoride released decreased gradually. The fluoride could be detected on the 28th day. 2) The amount of fluoride released from FluorEver was almost directly proportional to the volume of FluorEver blocks used. 3) The uptake of fluoride on enamel in contact with FluorEver was significantly high. 4) The release pattern of the fluoride of Fuji Ionomer was similar to that of FluorEver. The amount of fluoride released from Fuji Ionomer was greater than that of FluorEver immediately after immersion. However, from the 7th day of immersion, that of Fuji Ionomer was less than that of FluorEver. 5) The uptake of fluoride from FluorEver on the surface enamel was less than that of Fuji Ionomer. However, the uptake of fluoride from FluorEver on the subsurface enamel was greater than that of Fuji Ionomer.

Animals↗
PubMed1989

[How to remain healthy in a society of increasing numbers of senior citizens].

After the second World War, Japan made surprising economical progress reaching the second highest level in the world. Health care systems, including medical treatment for the elderly, also improved remarkably. As a result, the average life span of the Japanese has increased rapidly and, by the early twenty-first century, Japan is expected to become a Society with the highest number of senior citizens than any other country in the world. Still, the fact that many people are reaching a good old age does not necessarily mean that they are healthy. To live a healthy life in such a Society, effective measures against the diseases of adulthood are very important. The causes of such diseases are not always simple and are extensively combined with a large number of different factors which include a wrong life style. Early discovery and treatment of disease through group physical examinations (secondary prevention) are valuable, but more important than these is the prevention of disease (primary prevention). In order to grow old healthy, it is necessary to maintain a correct life style and, from youth on, an effort should be made to increase one's own health. It is important to be aware of the fact that one's own healthy life is created by one's own health care, and that keeping healthy while growing old is the duty of every individual living in a Society with a growing number of senior citizens.

Aged↗
PubMed1989

[Urolithiasis--changes in its treatment in the traditional surgical management].

Surgical treatments for urolithiasis in the upper urinary tract are reviewed on the basis of operation statistics at the Department of Urology, Osaka University Hospital for the past 30 years from 1957 to 1986. Open surgery was applied for 1,624 patients with urolithiasis in the kidney and ureter during this period. These operations accounted for 14.4% of the 11,300 cases of urological surgery at our department. Types and frequency of operations for urolithiasis were as follows: ureterolithotomies 697 cases (6.2%), pyelolithotomies including extended pyelotomy 376 cases (3.3%), nephrolithotomies 294 cases (2.6%), partial nephrectomies 132 cases (1.2%) and nephrectomies 125 cases (1.1%).

Adolescent↗
PubMed1989

[Primary hyperparathyroidism in a child with parathyroid crisis--review of 24 cases reported in Japan].

A 9-year-old boy, who had been admitted to the Pediatric Department for the examination of IgA nephropathy, was transferred to our urological clinic on Aug. 6, 1985, because of parathyroid crisis. Before urological consultation, he had been complaining of bilateral knee and calcaneal pain, anorexia and abdominal pain, which had persisted for several days. Laboratory data indicated serum Ca of 17.6 mg/dl, iP of 2.3 mg/dl and iPTH of 0.77 ng/ml. Roentgenographic examination such as chest, extremities and neck computed tomography showed no abnormal findings. The final diagnosis was parathyroid crisis caused by primary hyperparathyroidism and neck exploration was carried out on August. 10. Left upper parathyroid gland, which was 1 cm in diameter, was surgically removed. The other three glands were normal in size. Histological examination of the resected parathyroid gland revealed chief cell adenoma. In the post-operative course, serum Ca level was soon reduced to the normal range and bone pain disappeared rapidly. During the follow up period of 2.5 years, the patient was clinically free of recurrence. Only 23 cases of primary hyperparathyroidism in children have been reported in the Japanese literature. The clinical characteristics of these specific cases are that primary hyperparathyroidism in children shows a low incidence of renal lesion, but the complicated bone disease is of higher incidence compared with the adult cases. Histopathologically, parathyroid adenoma was frequently observed (14/19), and the other 5 cases were parathyroid hyperplasia.

Adenoma↗
PubMed1989

[Uncommon calcification of a pheochromocytoma: a case report].

A 62-year-old man with a 2-year history of hypertension was referred for evaluation of severe back pain, but his blood pressure was normal during his hospital stay. Plain radiography and excretory urography demonstrated central and eggshell-like calcification in the left suprarenal area. Computed tomographic scan confirmed similar shapes for the left adrenal calcifications. Laboratory examination revealed that the urinary normetanephrine was elevated. Left adrenal venography showed that the mass was in the middle to lower portion of the left adrenal gland. The most likely diagnosis was, calcified pheochromocytoma. The left adrenal tumor was removed surgically through a thoracolumbar incision on September 19, 1985. The blood pressure rose to 186/102 mmHg at the time of tumor manipulation. The tumor was a markedly hard mass, which was 3.5 x 3.5 x 3.0 cm and weighed 20 g. The histopathologic diagnosis was calcified pheochromocytoma. The patient remained symptomless after the operation.

Adrenal Gland Neoplasms↗
PubMed1989

[A case of adenocarcinoma of the bladder infiltrating to sigmoid colon].

A 65-year-old man was admitted to our clinic with the chief complaint of gross hematuria and burning on urination. Cystoscopy revealed a papillary broad base tumor on right lateral and posterior wall. Barium enema showed a tumor of sigmoid colon. The other gastrointestinal and genitourinary tracts were examined but no tumor lesion could be found. Total cystectomy and partial resection of sigmoid colon were done, and the urinary tract was reconstructed using a Kock continent ileal reservoir. Histological findings revealed adenocarcinoma of its infiltration to the sigmoid colon.

Adenocarcinoma↗
PubMed1988

Immunohistochemical study of nodular hyperplastic parathyroid glands in patients with secondary hyperparathyroidism.

Thirty-seven nodular hyperplastic parathyroid glands obtained by subtotal parathyroidectomy from 11 haemodialysed patients with secondary hyperparathyroidism were examined both pathologically and immunohistochemically. Four consecutive sections of the largest section-surface of each gland were subject to 4 different stains (haematoxyline-eosin, Grimelius, and the immunohistochemical stains for parathyroid hormone and chromogranin A) for comparison of each nodule. It was found that the major part of each nodule consisted of a single cell type with a single pattern of cells. These reacted uniformly to each stain. The mechanism involved in the storage and secretion of the secretory granule appeared to be regulated at the nodule and not at the cell level. The results suggest that the nodules may come from a monoclonal proliferation of a single parathyroid cell. Our present light microscopic immunohistochemical study, failed to demonstrate completely identical immunoreactive positivity of each nodule or each parathyroid cell to PTH. Chromogranin A or secretory protein-I did not indicate the coexistence of PTH and SP-I in the same secretory granule, which was in good agreement with the electron microscopic immunocytochemical study of Arps using bovine parathyroid glands. Our present study, however, provides good evidence that chromogranin A positivity is demonstrable in the human parathyroid gland outside the adrenal medulla and sympathetic nerves.

Humans↗
PubMed1988

Analysis of strongly acidic amino acids by the conventional amino acid analyzer: application to determination of protein-bound cysteine and glutathione.

A rapid analysis method of strongly acidic amino acids and related compounds by a simple modification of an existing amino acid analyzer is presented. In this method, an anion-exchanger column (2.6 X 150 mm) packed with Hitachi 3013-N resin was developed with 0.2 M citric acid. Complete separation of phosphothreonine, phosphoserine, phosphotyrosine, cysteic acid, homocysteic acid, and glutathionesulfonic acid was achieved within 35 min, with no regeneration of the column being required. Tyrosine-O-sulfate was analyzed by the same column using 2 M sodium acetate buffer, pH 5.5. Performic acid oxidation of a variety of proteins and direct analysis of the products by this system successfully detected cysteine, homocysteine, and/or glutathione bound to proteins through disulfide bonds. This suggest the potential use of the method for analysis of the states of protein thiol groups, especially those of clinically significant mutant proteins where mutation of arginine to cysteine is rather frequently recognized.

Animals↗
PubMed1988

Human histidine-rich glycoprotein gene: evidence for evolutionary relatedness to cystatin supergene family.

The human chromosomal histidine-rich glycoprotein (HRG) gene has been isolated and its molecular structure was partially characterized. The gene is approximately 11 kb in length and contains nine exons and eight introns. Locations of the introns in HRG gene coding for cystatin domains are essentially identical with those of cystatin SN, SA and C, and kininogen genes. These results provide direct evidence that HRG belongs to a supergene family that includes cystatin SN, SA and C, and kininogen, and also demonstrate high conservation of the intron-exon organization among this supergene family.

Base Sequence↗
PubMed1988

Promotive effect of urine from patients with primary hyperparathyroidism on calcium oxalate crystal aggregation in an in vitro whole urine system.

Urine from patients with calculi produced by primary hyperparathyroidism was examined to determine its promotive effect on calcium oxalate crystal aggregation. The study was carried out in an in vitro whole urine system and the particle size distribution assay was done by Coulter Counter, Model TAII. Of urine samples from 19 hyperparathyroid patients, 15 showed obvious promotion of calcium oxalate crystal aggregation. It is not known what kind of substances in such urine led to this phenomenon and whether these unknown factors act by actually promoting crystal aggregation or by blocking substances of inhibitors.

Adult↗
PubMed1988

Possible involvement of diacylglycerol-activated, Ca2+-dependent protein kinase in glucose memory of the rat pancreatic B-cell.

Exposure to high concentrations of glucose potentiates insulin release from the pancreatic B-cell stimulated by various secretagogues after an interval under basal condition. We studied the role of diacylglycerol-activated, Ca2+-dependent protein kinase (protein kinase C) in this priming effect of glucose in rat pancreatic islets, using 12-O-tetradecanoyl phorbol-13-acetate (TPA), 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7),N-(2-guanidinoethyl)-5-isoquinolinesulfonamide (HA-1004) and forskolin. The priming effect of glucose was mimicked by 10 nmol/l of TPA, an activator of protein kinase C, but not by 5 mumol/l of forskolin, which increases cAMP via activating adenylate cyclase. When pancreatic islets were exposed to glucose (10 mmol/l) together with 50 mumol/l of H-7, an inhibitor of protein kinase C, the secretory response to glucose (10 mmol/l) after a 30-min interval was significantly reduced compared with that in the islets previously exposed to 10 mmol/l glucose alone. In contrast, this was not the case for HA-1004, its inhibitory activity against protein kinase C being less potent than H-7. These findings suggest that protein kinase C may play an important role in the priming effect of glucose on the pancreatic B-cell.

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine↗
PubMed1988

[A case of Kallmann's syndrome].

A 13-year-old boy visited our hospital with the chief complaint of right undescended testis and retardation of secondary sexual characteristics. Central hyposmia and sensorineural hearing loss were found. The plasma levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) were low and the reaction to LH-releasing hormone (RH) test was poor. After repeated LH-RH tests, a good response in plasma levels of LH and FSH was observed. The diagnosis of Kallmann's syndrome was made from the above findings. The testicular biopsy specimen from him showed immature testis without any developed Leydig or Sertoli cells. To induce secondary sexual characteristics, 2000 I.U. of human chorionic gonadotropin (hCG) was administered to him twice a week for 3 months. The administration of hCG resulted in elevation of plasma testosterone level, swelling of testes, increase of pubic hair and spurt of height.

Adolescent↗
PubMed1988

[Lipogranuloma with marked eosinophile infiltration in male genitalia].

A characteristic lipogranuloma in the male genitalia is presented. Histopathological examination revealed a granuloma resembling sclerosing lipogranuloma with marked eosinophile infiltration. Only 11 cases with such a histopathological feature have been reported. Including this case all cases have similar localization, shape and clinical course. The genesis of these granulomas is discussed.

Adult↗
PubMed1988

[Citrate (CG-120) therapy for urolithiasis. 1. Clinical effects].

Urinary citrate is an important determinant for crystallization of calcium salts, and recently oral administration of citrate has been suggested to be clinically useful in the management of renal stone disease. The effect of CG-120, a citrate compound (potassium citrate, sodium citrate and citric acid) produced by Dr. Madaus (Germany), on upper urinary tract stones was investigated in 398 patients in this study group. The patients were treated with 3 or 4 g CG-120 daily. Two hundred thirty-one of them were treated accurately according to the protocol of the study for more than 32 weeks. The cumulative percentage of positive clinical effect for the stone (disappearance, passage or decrease in size) was 30.3% (70/231). There were no differences in the clinical effect between the group of 3 g/day and the group of 4 g/day. CG-120 seemed to be more effective in the cases of ureteral stone, young patients and females, but was less effective in the recurrent stone formers. Although there were 45 episodes of side effects in 38 patients in this study, no serious side effects attributed to CG-120 were experienced. CG-120 was proved as a useful drug in the treatment of upper urinary tract calculi as well as its prevention.

Adolescent↗
PubMed1988

[Citrate (CG-120) therapy in urolithiasis. 2. Effect on urinary and serum biochemistry ].

The long-term effects of citrate therapy (CG-120, 3 g/day or 4 g/day) were examined in 398 patients with upper urinary tract calculi. We studied the influence of citrate therapy on urinary and blood biochemistry in 353 of them. CG-120 caused a sustained increase in urinary citrate, urinary pH and potassium, but no substantial or significant changes in other urinary parameters (uric acid, phosphate, oxalate, sodium, chloride and urine volume). Although urinary calcium decreased significantly up to the 24th week, it did not change significantly there after and it tended to increase at the 54th week. Urinary creatinine excretion decreased after 34 weeks of administration, but this phenomenon could not be explained, because the level of blood urea nitrogen and serum creatinine was not elevated in any case before administration. There were no changes in the serum calcium, magnesium, phosphate, uric acid, sodium, potassium or chloride level.

Blood Chemical Analysis↗