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Biomedical subjects

T Kohno

Publications and source records attributed to T Kohno.

At least 433 records · Page 24Linked to original sources
PubMed1983

Falciform retinal fold as sign of familial exudative vitreoretinopathy.

We studied family members of 9 patients with falciform retinal fold, and found a number of cases showing features of familial exudative vitreoretinopathy (FEVR) in the fundi. Retinal fold was also seen in the eye of a cousin of the propositus. Three cases with falciform retinal fold were bilateral and 7 cases were unilateral. Retinal folds were located in the temporal half of the fundis in 11 of the 13 eyes with retinal fold. These 11 eyes showed avascularized zones of retinal vessels with scalloped edges in the periphery; in the 2 remaining eyes the retinal vessels were restricted within the fold. Thirty-one eyes of 18 cases, members of 7 pedigrees, showed features of FEVR. The observed avascularized zones with scalloped pattern of the vessels and vitreoretinal involvements were divided into 3 groups: 23 eyes of stage 1, 6 eyes of stage 2, and 2 eyes of stage 3, respectively. It was, therefore, concluded that falciform retinal fold being located temporally or bilaterally could be one of the signs of FEVR and that FEVR was a disease affecting regression of the hyaloid vascular system and development of the retinal vessels during fetal life. FEVR was classified into 4 groups: type 1, type 2, type 3 and type 4 of falciform retinal fold. The disease may be transmitted as autosomal dominant inheritance.

Adult↗
PubMed1982

Identification of microglia cell of the rat retina by light and electron microscopy.

Distribution of microglia cells was studied in the normal retina of Wistar rats kept in a specific-pathogen-free condition, using a combined technique of light and electron microscopy with the weak silver carbonate staining method of del Rio-Hortega. Typical microglia cells were found mainly in the inner plexiform layer. By electron microscopy these cells were easily identified by metallic deposition in the cells, and had a small oval nucleus with a prominent chromatin pattern, which was one of the most characteristic features of the cell. Based upon these fine structures, microglia cells were identified in the nonimpregnated, ordinarily prepared retina by electron microscopy. These cells contained lysosomes, lipofuscin granules, Golgi apparatus, and long, narrow cisternae of rough-surfaced endoplasmic reticulum mainly at both sides of the perikaryon. These features were identical with those of microglia cells in the central nervous system. Microglia cells were found to be widely distributed in the inner portion of the retina, most of the cells locating closely to ganglion cells or capillary walls, and occasionally in the inner plexiform layer. The nuclear feature of the cell was also recognizable by light microscopy in 1-micron-thick Epon sections stained with toluidine blue. Serially cut thick sections of the retinal ribbon revealed that microglia cells were widely distributed from the peripapillary to the ora serrata region. From the present study, it is concluded that the microglia cell can be considered a component of the normal retina. This is the first report on the precisely described fine structures of the retinal microglia cells.

Animals↗
PubMed1980

Analysis of gas chromatography/electron capture detector sensitive substances in human serum in relation to the determination of iodochlorhydroxyquin concentration.

We found that human sera can be divided into five types depending on the gas chromatography/electron capture detector (GC/ECD) chromatogram pattern. A preliminary GC/MS study on one of the GC/ECD peaks has suggested the presence of a hitherto unknown iodine-containing substance of probably endogenous origin.

Chromatography, Gas↗
PubMed1980

Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.

A series of 2-(2-pyridinyl)benzimidazoles was synthesized and evaluated for antiinflammatory activity by the carrageenan-induced rat paw edema assay. Among several active derivatives, 2-(5-ethylpyridin-2-yl)benzimidazole (6) was selected for further study. A comparison of compound 6 with phenylbutazone and tiaramide revealed that 6 possesses stronger activity in acute inflammatory models possibly with slightly less gastrointestinal irritation than both phenylbutazone and tiaramide.

Animals↗
PubMed1980

Developmental process of chronic subdural collections of fluid based on CT scan findings.

One hundred twenty-four follow-up scans were performed on 24 patients who had had posttraumatic subdural collections of low density. Of the 24 patients, 6 developed chronic subdural hematomas. Six other subdural collections showed a temporary increase in attenuation but eventually resolved. The remaining 12 subdural collections resolved without apparent increase in density. Illustrative cases are presented with computed tomographic scans. The identity of these posttraumatic subdural lesions of low density is discussed. They seem to be posttraumatic subdural hygromas.

Adult↗
PubMed1979

Electrolyte effects on the activity of mutant enzymes in vivo and in vitro.

All temperature-sensitive histidine auxotrophs of Salmonella typhimurium tested are corrected by addition of neutral salts to their growth medium. The correctability seems to result from direct electrolyte effects on mutant protein stability since several of the mutant proteins are also salt correctable in vitro.

Alcohol Oxidoreductases↗
PubMed1979

Causes of locking metacarpophalangeal joint of the thumb and its non-operative treatment.

The non-operative method of reduction of locking metacarpophalangeal joint of the thumb is described, and illustrated by four case reports. Experimental studies in the hands of a fresh cadaver are also described. Locking of the metacarpophalangeal joint of the thumb can be produced by slight external forces, insufficient to damage strong tissues. Incarceration of the sesamoid bone is anatomically impossible, but incarceration of the proximal portion of the volar plate is believed to be the true cause. This incarceration can be reduced easily by our non-operative method along with intra-articular injection of local anaesthetics.

Adult↗
PubMed1979

Muscle flap with simultaneous mesh skin graft for skin defects of the lower leg.

Since 1974 we have performed muscle flap transposition (myoplasty) for the treatment of a skin loss of the lower leg with associated exposure of the bone. In order that the operative treatment may be completed in one stage, mesh skin graft was done simultaneously with muscle transfer. Twelve cases so far have been treated successfully by this procedure, the mesh skin graft taking well on the muscle flap.

Adolescent↗
PubMed1979

Polychlorinated biphenyls poisoning in monkey eye.

Poisoning by polychlorinated biphenyl(s) (PCB) in humans leads to cutaneous and ocular findings. A white, cheeselike secretion issuing from the orifice of the Meibomian gland duct when the eyelid is squeezed is one sign of this intoxiation. In the rhesus monkey, abnormal hyperkeratosis of the ductal epithelium was observed histopathologically.

Animals↗