Biomedical subjects

T Kocher

Publications and source records attributed to T Kocher.

At least 37 records · Page 2Linked to original sources

PubMed2003

[Modern treatment options for Zenker's diverticulum: indications and results].

Conventional transcervical therapy of Zenker's diverticulum comprises diverticulectomy, invagination, diverticulopexy and myotomy, which may be combined with the aforementioned methods. Transoral diverticuloesophagostomy is performed by diathermy, lasers or staplers through a rigid esophagoscope, or more recently by diathermy applied via a flexible endoscope. Morbidity of transcervical procedures ranges between 3 (myotomy) and 23 % (diverticulectomy + myotomy). The percentage of patients with at least significantly improved symptoms is 92 % or more, while recurrences occur in 5.7 (diverticulectomy alone) to 21 % (invagination). Transoral procedures have a morbidity of 9 (stapler) to 26 % (Laser), while symptoms improve in 91 (diathermy through rigid esophagoscope) to 99 % (diathermy via flexible endoscope), however in up to 64 % of patients reoperations are necessary. Small diverticula (Brombart I/II) can be treated by diverticulectomy (with/without myotomy) or flexible endoscopy, larger diverticula in general by all methods. Patients younger than 60 years should undergo diverticulectomy, elderly multimorbid patients should be treated by transoral procedures.

Electrocoagulation↗

PubMed2003

The interleukin-1 polymorphism, smoking, and the risk of periodontal disease in the population-based SHIP study.

Several studies have shown a role for interleukin-1 gene cluster polymorphisms in the risk assessment for periodontal diseases. In the Study of Health in Pomerania (SHIP), 3148 subjects were randomly selected from the population and assessed for a broad range of diseases and environmental/behavioral risk factors. From the complete study group in the age 40 to 60 years, N = 1085 subjects were genotyped for the interleukin-1 genotype composite polymorphism in relation to periodontal parameters. The study objective was to elucidate the gene-environment interaction between the risk factors smoking and IL-1 polymorphism. An increased risk of periodontal disease was found for IL-1 genotype-positive smokers: odds ratio adjusted for age, sex, education, and plaque OR = 2.50 (95% C.I. 1.21 to 5.13; p = 0.013). This was not the case with subjects who never smoked: OR = 1.09 (0.73-1.62; p = 0.676). These results support the hypothesis of gene-environmental interaction in periodontitis.

Adult↗

PubMed2003

Caries prevalence in an adult population: results of the Study of Health in Pomerania, Germany (SHIP).

PURPOSE: The aim of this study was to assess the caries prevalence in the adult population of Pomerania, Germany in comparison to national and international data. MATERIALS AND METHODS: The study sample comprised 4,022 randomly selected subjects who were examined from October 1997 to May 2001 within the "Study of Health in Pomerania" (medical and dental, population-based cross-sectional study in Pomerania, Northeast Germany. Response rate: 69%. Age range of subjects: 25-79 yrs). Carious defects, fillings and missing teeth were diagnosed and the DMFT/S scores were calculated according to WHO guidelines (1997). These figures were compared to other German, Swedish and US data. RESULTS: Women exhibited higher mean DMFT and DMFS values in all age groups than men. The mean DMFT/S scores were slightly higher than the values for the only two available nationally representative age groups in Germany. The prevalence of primary carious lesions or secondary caries was very low, resulting in minor treatment needs (decayed surfaces: mean 0.95 +/- 3.3) and high care indices (FS/DFS) for all age groups (90-95%). In contrast to this, the mean numbers of fillings in adults and especially of missing teeth in seniors were much higher in Pomerania for all age groups than in the Swedish and US adult population, where a caries decline was demonstrated. CONCLUSION: In spite of a very low prevalence of primary carious lesions and secondary caries, the mean number DMFT/S and especially MT/S scores in the Pomeranian adult population are high in comparison with Swedish and US data, but differed only slightly from the limited available national data for Germany.

Adult↗

PubMed2002

Colonic involvement in non-necrotizing acute pancreatitis: correlation of CT findings with the clinical course of affected patients.

The purpose of this study was to describe CT findings of colonic involvement in acute non-necrotizing pancreatitis and to analyze the correlation between colonic wall thickening at CT and the clinical course of these patients. The CT examinations of 19 consecutive patients with acute non-necrotizing pancreatitis who were not treated with antibiotics initially were analyzed retrospectively. The severity of acute pancreatitis was categorized according to the CT severity index (CTSI) and the presence of colonic wall thickening at the initial CT was compared with the clinical course of all patients. Seven of 11 patients with a CTSI of 4 showed a colonic wall thickening, whereas the remaining patients with a CTSI of 4 (n=4), CTSI of 3 (n=5), and CTSI of 2 (n=3) showed no colonic abnormalities at CT. Patients with colonic wall thickening presented more often with fever, showed higher levels of infectious parameters, needed more often antibiotic therapy, and had more requests for additional CT examinations and CT-guided fluid aspirations as well as a longer duration of hospital stay as compared with patients without colonic wall involvement, even if the latter presented with the same CTSI initially. It is well known that translocation of the colonic flora may significantly influence the clinical course of patients with acute pancreatitis, and our results indicate that patients with acute pancreatitis who present with colonic wall thickening at CT have an increased risk for a complicated clinical course regarding systemic infection.

Acute Disease↗

PubMed2002

Complications due to gallstones lost during laparoscopic cholecystectomy.

BACKGROUND: The aim of this study was to identify predisposing factors for complications after gallstone spillage during laparoscopic cholecystectomy (LC). METHODS: Papers derived from Medline search and papers from reference lists within these papers were studied. Ninety-one reports on complications caused by lost gallstones published between 1991 and 1998 were analyzed. These patients were compared with cases in published series on LC in general. RESULTS: Gallbladder perforation (20%) and stone spillage (9%) were the two most common complications of LC which occurred during the dissection (75%) and removal (25%) of the gallbladder. Predisposing factors for developing complications after stone spillage were: older age, male sex, acute cholecystitis, spillage of pigment stones, number of stones (>15) or size of the stone (Ø > 1.5 cm), and perihepatic localization of lost stones. CT-scan and ultrasound examination proved best for the recognition of complications caused by lost stones. Explorative laparotomy and surgical removal of the stones was the most frequently used therapy. CONCLUSIONS: Gallbladder perforation and stone spillage might cause hazardous complications. In cases with loss of numerous or large pigment stones which cannot be retrieved by laparoscopy, intraoperative conversion to open surgery can be justified.

Abscess↗

PubMed2002

[Malignant transformation of perianal Buschke-Löwenstein tumor. Extensive abdominoperineal rectum excision and reconstruction with transpelvic myocutaneous rectus abdominis muscle flap].

INTRODUCTION: The Buschke Löwenstein tumor (giant condyloma) in its perianal variant is an extremely rare disease caused by human papilloma virus. Although of histologically benign appearance, it infiltrates and destroys the surrounding tissue. There is a high risk of local recurrence and malignant transformation. The treatment of choice is wide surgical resection. CASE: A 56-year-old woman presented with perianal giant condyloma infiltrating the rectum and vagina. The extensive soft tissue defect resulting from wide resection was filled with a transpelvic myocutaneous rectus abdominis flap. Histology showed a squamous cell carcinoma arising in the Buschke Löwenstein tumor with clear resection margins. Therefore, the patient was irradiated locally after uneventful primary wound healing. CONCLUSION: A simultaneous reconstruction of a large pelvinoperineal soft tissue defect with the transpelvic myocutaneous rectus abdominis flap allows primary healing, accelerated rehabilitation, and safe adjuvant radiotherapy without risk of serious radiation damage to the small bowel by preventing it from protruding into the pelvic defect.

Anal Canal↗

PubMed2002

Quantification of gingival edema using a new 3-D laser scanning method.

OBJECTIVES: The aim of the study was to investigate the suitability of measuring volume differences in the gingival tissue for monitoring changes in the inflammatory status of the gingiva. MATERIALS AND METHODS: Data for this investigation were obtained from a mouthrinse evaluation which was performed as a 4-week, double-blind, placebo-controlled, cross-over study in which localised experimental gingivitis was induced. 24 volunteers were enrolled in the study. Only the data from the placebo period of each subject were used in the current investigation. During the plaque accumulation periods, plaque guards were worn during routine performance of oral hygiene measures to prevent any plaque removal from the experimental area (1st and 2nd premolars and molars in one upper quadrant). Clinical examinations with assessment of plaque and gingivitis were performed on days 0, 4, 7, 14, 21, 28 and 42. Volume differences in the gingival papillae were determined between day 0 and days 21, 28, and 42, and between days 28 and 42 by taking measurements from replicas of the respective clinical situations using a 3-D laser scanner and reference-free automated 3-D superimposition software. Data were analysed with the Wilcoxon signed ranks test. RESULTS: Plaque accumulation in the experimental area resulted in a highly significant increase (p<0.001) of inflammation of the gingival papillae. The mean (standard deviation) papillary GI at baseline was 0.23 (0.34) as compared to 1.22 (0.27) and 1.2 (0.31) on days 21 and 28, respectively. The mean increase in volume of all papillae as compared to baseline was 25,478 micrometer3 after 21 days and 24,210 micrometer3 after 28 days. After resuming a normal oral hygiene regimen, mean volume of the papillae decreased between days 28 and 42 by 19,250 micrometer3. CONCLUSION: With this novel method, gingival papillary edema can be quantified in vivo from replicas of the clinical situation.

Adult↗

PubMed2002

The effect of a polyhexamethylene biguanide mouthrinse compared to an essential oil rinse and a chlorhexidine rinse on bacterial counts and 4-day plaque regrowth.

OBJECTIVES: For various clinical applications, polyhexamethylene biguanide hydrochloride (PHMB) has been used for many years as an antiseptic in medicine. Recently, a 0.04% PHMB mouthwash was shown to inhibit plaque regrowth and to reduce oral bacterial counts. In this study, a 0.12% PHMB mouthrinse (A) was compared with a negative control placebo rinse (10% ethanol, flavour) (B), a positive control 0.12% chlorhexidine rinse (C), and a commercially available mouthrinse containing essential oils (Listerine) (D). MATERIALS AND METHODS: The study was a double-blind, randomised 4-replicate 4 x 4 Latin square cross-over design in which plaque regrowth was measured. The in vivo antibacterial effect was assessed by taking bacterial counts from the tooth surface and mucosa 4 h after the first rinse with the preparations on day 1 and prior to the clinical examination on day 5. 16 volunteers participated and, on day 1 of each study period, were rendered plaque-free, ceased toothcleaning, and rinsed 2x daily with the allocated mouthrinse. On day 5, plaque was scored and smears were collected according to the protocol. Washout periods were 9 days. Data were analysed using ANOVA with Bonferroni HSD adjustment for multiple comparisons (significance level alpha=0.05). RESULTS: The 0.12% PHMB mouthrinse (A) was significantly more effective in inhibiting plaque than the placebo (B) but no significant differences could be observed between A and 0.12% chlorhexidine (C), or between A and Listerine (D). Bacterial count reductions on the tooth surface with PHMB (A) were significantly greater compared to the placebo (B) after 4 h and significantly greater compared to B and D after 5 days. Chlorhexidine (C) was more effective than A after 5 days. On the mucosa, chlorhexidine (C) was significantly more effective in reducing bacterial counts than the other 3 treatments at both time points investigated. PHMB (A) was significantly more effective in reducing bacterial counts than the placebo (B) after 4 h and after 5 days, and than D after 4 h. CONCLUSION: Consistent with a previous study, a PHMB mouthrinse was shown to inhibit plaque recolonisation and to reduce oral bacterial counts, indicating that PHMB may find applications in the prevention of plaque-associated diseases.

Adult↗

PubMed2002

Learning root debridement with curettes and power-driven instruments. Part I: a training program to increase effectivity.

BACKGROUND/AIMS: In a dummy-head trial, we assessed how effectively untrained operators were able to learn scaling with curettes and power-driven instruments. METHODS: Two untrained operator groups (n = 11 each) received six 2-h lessons during a 10-week period following a training program. Subgingival scaling was performed with curettes (GRA) and a power-driven system (PP). At 6 test days each subject had to instrument 10 test teeth. The percentage of debrided area was assessed with an image analysis program. Learning success was measured as a percentage of debrided root area and scaling time. Furthermore, the effectivity was related to difficulty in anatomical situations and access to root surfaces. Statistical analysis was carried out with SPSS. RESULTS: At baseline, effectivity was 63.1% (GRA) vs. 52.3% (PP). Between weeks 9 and 11, operators reached a plateau for group GRA at 84.7% and group PP at 81.3%. Scaling time did not differ between the two groups. Debridement of teeth with complex root shapes that were hard to access was less effective with the power-driven system. CONCLUSION: Independent of the instrument used, untrained operators were only able to debride root surfaces at low levels of efficacy. With systematical training, effective scaling with the power- driven system was as easy to learn as with hand instruments. On root surfaces with complicated shape and anatomy or difficult accessibility, the power-driven system works significantly less effectively.

Alveolar Bone Loss↗

PubMed2002

Learning root debridement with curettes and power-driven instruments in vitro: the role of operator motivation and self-assessment.

The influence of systematic dummy-head training with Periopolishe (PP, group A) and Gracey instruments (GRA, group B) on the effectiveness of root debridement was evaluated by Rühling et al., 2002 (9). Their results indicate that independent of the instrument used, untrained operators were only able to debride root surfaces at low levels of effectiveness. It was possible to increase effectiveness to a high level through systematic training in both groups. The aim of the present study was to assess the role of operator motivation and self-assessment on scaling effectiveness. Before baseline, operators were asked to answer a questionnaire rating the expectation of the instrument performance. Four groups of inexperienced operators (n = 11 each) received 10 weeks dummy-head training. In groups A (GRA) and B (PP), training was combined with a motivational programme. Groups C (GRA) and D (PP) received the same training, but no additional motivational programme. In a dummy-head, 10 test teeth were debrided and operators were asked to estimate their effectiveness of debridement at each test day. Effectiveness was calculated as percentage of debrided root area on 10 test teeth at different time points with an image analysis programme (NIH Image) and ANOVA. Two groups were compared using the Mann-Whitney U-test (unpaired) and the Wilcoxon signed ranks test (paired). Motivated groups (A and B) reached about 25% higher debridement results (p < 0.001) and were able to estimate their effectiveness more precisely compared to groups C and D. In the low motivation groups (C and D), overestimation of more than 20% was evident (p < 0.001). The questionnaires revealed underestimation of the GRA instruments and overestimation of PP instruments. Operator motivation and self-assessment greatly influence learning of effective root debridement.

Analysis of Variance↗

PubMed2001

Removal of HA and TPS implant coatings and fibroblast attachment on exposed surfaces.

The removal of implant coatings may be necessary if rough implant surfaces are exposed subgingivally due to progressive peri-implant bone loss or if they are also supragingivally exposed because of progressive gingival recession, thus facilitating plaque formation and impairing tooth cleaning done at home. The aim of this experimental study was to develop diamond-coated files and rubberized polishers for machine-driven instrumentation of implant cylinders, and present an instrumentation concept for the complete removal of rough titanium plasma spray (TPS) and hydroxylapatite (HA) layers and polishing exposed titanium surfaces. The surface structure and its possible contamination by the instrumentation process was investigated using laser profilometry, scanning electron microscopy, and x-ray fluorescence analysis. The effect of impurities on the growth of human fibroblasts was tested in cell culture. The results show that TPS and HA implant coatings can be removed with the modified implant files. After polishing the exposed titanium surfaces, roughness depths of Rz=4.6 microm (TPS) and Rz=5.7 microm (HA) and, for implant cylinders, 3.4 microm were found. During the instrumentation of implant surfaces, contamination with the material of the instrument must be expected. It was shown that, in principle, growth of human gingival fibroblasts on the instrumented surfaces is possible. The cells were intimately associated with one another and, compared to culture controls, demonstrated good adhesion with strict orientation to the microstructure of the scoring left by instrumentation. The biological consequences and mechanisms of cell adhesion on instrumented surfaces require further investigation.

Cell Adhesion↗

PubMed2001

Subgingival polishing compared to scaling with steel curettes: a clinical pilot study.

BACKGROUND: Recently, we have developed teflon-coated sonic scaler inserts which remove plaque without removing tooth substance; they polish subgingivally. In a preclinical test, we showed that these modified inserts remove plaque nearly as effectively as do conventional sonic scaler inserts. The present investigation was intended as a proof-of-principle of subgingival polishing. The aim was to study the effect of subgingival polishing on the resolution of gingival inflammation in comparison to conventional scaling. MATERIAL AND METHODS: In 10 patients with moderate to advanced periodontal disease, who had at least 2 single-rooted teeth with a probing depth of >6 mm in each quadrant, all single-rooted teeth were subjected to one treatment regimen consisting of 2 instrumentation episodes (1st/2nd treatment): curette/curette, curette/teflon-coated sonic scaler, teflon-coated sonic scaler/teflon-coated sonic scaler, and an untreated control. The second treatment session was performed 3 months after the first instrumentation, and the final registration 3 months after the second instrumentation. Clinical measurements included probing depth, change of clinical attachment level, bleeding upon probing, and plaque scores. RESULTS: Probing depth, attachment level, and bleeding scores were reduced in the 3 instrumentation groups versus the control group in the 1st period; in the 2nd period, no further change occurred. Subgingival polishing with teflon-coated sonic scaler inserts was slightly less effective than conventional scaling. CONCLUSION: Subgingival polishing with teflon-coated sonic scaler inserts seems to be nearly as effective as conventional scaling. Thus, it may be the instrumentation of choice for maintenance treatment of residual pockets.

Adult↗

PubMed2001

Retrospective comparison of clinical variables between compliant and non-compliant patients.

BACKGROUND: The aim of this retrospective study was to evaluate if patients with moderate to advanced periodontitis had comparable periodontal conditions at baseline and during supportive periodontal therapy (SPT) whether they were compliant or not. METHOD: Patient-related variables were compared: age, tooth mobility, furcation involvement, number of teeth, pocket probing depth, plaque index. Compliant patients (n = 142) received complete periodontal treatment and were followed over at least 10 years (group A). Non-compliant patients either discontinued supportive periodontal therapy (n = 42, group B) or dropped out before or during periodontal surgery (n = 44, group C). RESULTS: At baseline, there were no significant differences between the 3 groups except for mobility. During SPT, mean pocket probing depth and plaque index differed significantly. CONCLUSION: These results indicate that non-compliant patients compared to compliant patients had similar periodontal conditions at baseline, but responded less favourably to periodontal surgery and maintenance.

Adult↗

PubMed2001

Effects of SCN-/H2O2 combinations in dentifrices on plaque and gingivitis.

OBJECTIVES: A 10-week, double-blind, placebo-controlled clinical study on 140 male subjects was conducted to determine the effect on plaque and gingivitis of 5 dentifrices containing various thiocyanate (SCN-)/hydrogen peroxide (H2O2) combinations. MATERIALS AND METHODS: The dentifrices consisted of a gel base without any detergents or abrasives (placebo, group A) to which SCN- and/or H2O2 were added as follows: 0.1% SCN- (group B), 0.5% SCN- (group C), 0.1% SCN-/0.1% H2O2 (group D), 0.5% SCN-/0.1% H2O2 (group E) and 0.1% H2O2 (group F). A baseline examination was performed in which the Silness and Löe Plaque Index (PI), the Mühlemann and Son Sulcus Bleeding Index (SBI), and the amount of gingival crevicular fluid (GCF) were recorded using the Periotron 6,000 on teeth 16, 12, 24, 36, 32, and 44. The subjects were randomly assigned to either the placebo group (n = 40) or one of the test groups (n = 20) and used their respective dentifrices over a period of 8 weeks. Finally, each group used the placebo for another 2 weeks (wash-out). Re-examinations were performed after 1, 4, and 8 weeks and the 2-week wash-out period employing the clinical parameters used at baseline. Intragroup changes were analyzed with the Wilcoxon signed-ranks test, using the baseline and wash-out points as references. The Mann-Whitney U test was used for comparisons between the treatment groups and the placebo group. RESULTS: At the 8-week examination, the plaque index in group E (p = 0.017) and group F (p = 0.032) was lower than in the placebo group. The Sulcus Bleeding Index in group F after 1 week was increased (p = 0.023) and the SBI in group E after 8 weeks was reduced (p = 0.047) as compared to the placebo group. CONCLUSION: The results demonstrated that a dentifrice containing 0.5% SCN- and 0.1% H2O2 but no detergents or abrasives inhibited plaque and decreased gingivitis.

Adolescent↗

PubMed2001

Substance loss caused by scaling with different sonic scaler inserts--an in vitro study.

BACKGROUND, AIMS: Depending on the phase of periodontal treatment, power-driven inserts with different power levels are necessary: during initial treatment and flap operations, it must be possible to remove calculus which firmly adheres to the root surface with great efficiency; in contrast, gentle root-surface instrumentation has a high priority during maintenance treatment. Recently, modified sonic scaler inserts have been introduced: diamond-coated inserts for open flap operations and slim probe-shaped sonic scaler inserts for deplaqueing during maintenance. METHOD: We compared the substance removal by these inserts to that of a conventional insert. In a bench system which allows application force, stroke height, and width and frequency of instrumentation to be monitored and also permits assessment of the topography before and after instrumentation (yielding depth removal and removed volume), we instrumented aluminum rods in triplicate and bovine roots in a 5-fold repetition. RESULTS: With high application forces (1.0 N), the diamond-coated inserts removed 30 to 50% more substance than the conventional one. Except for the slim inserts, there was a significant linear relationship between increasing force and removed volume. Probe-shaped inserts do not remove considerable substance even with increasing pressures. CONCLUSIONS: Diamond-coated inserts remove tooth substance very effectively and must thus be handled with care: more pressure effects more removal. Probe-shaped inserts can be used without risk during maintenance visits.

Animals↗

PubMed2001

Subgingival polishing with a teflon-coated sonic scaler insert in comparison to conventional instruments as assessed on extracted teeth (II). Subgingival roughness.

AIM: To assess the root surface roughness and topography on extracted teeth using different instruments. MATERIAL AND METHODS: In the present study, laser profilometry was used to examine the 3-D roughness values Ra and Rz and topography of root surfaces of periodontally-involved teeth instrumented in vivo with curette, conventional ultrasonic device, conventional or teflon-coated sonic scaler insert, or the Periotor instrument (12 teeth per instrument type), and compare these with uninstrumented cementum surfaces. RESULTS: The roughness values Ra and Rz of the roots treated with the different instruments showed a similar pattern: curettes and the Periotor instrument produced the smoothest surfaces (Ra about 1.5 microm, Rz 30 microm); the 4 other instruments created similar Ra values of approximately 2-3 microm and Rz roughness of about 50-70 microm, which equals the untreated root surface. For Ra, the difference between the curette or the Periotor instrument and the teflon-coated sonic insert or ultrasonic insert was significant, and for Rz, a significant difference was found between the curette or the Periotor instrument and ultrasonic insert. As opposed to surfaces debrided with the Periotor and teflon-coated sonic scaler, it appears that hand instruments markedly reconfigure surfaces. CONCLUSION: The lowest root-surface roughness values were obtained with hand instruments. The teflon tubing on the sonic scaler insert effected no change of topography or roughness as compared to uninstrumented, control surfaces. However, it must be pointed out that hard-tissue removal was not investigated.

Adolescent↗

PubMed2001

Effect of a polyhexamethylene biguanide mouthrinse on bacterial counts and plaque.

OBJECTIVES: For various clinical applications, polyhexamethylene biguanide (PHMB) has been used for many years as an antiseptic in medicine. Little is known, however, of its antibacterial activity in the oral cavity and its ability to inhibit plaque formation. In this study, a 0.04% PHMB mouthrinse (A) was compared with a negative control placebo rinse (10% ethanol, flavour) (B) and 2 positive control chlorhexidine rinses, one of which was a 0.12% aqueous solution (C) and the other a commercially available mouthrinse (Skinsept mucosa) diluted to a chlorhexidine concentration of 0.12% (D). MATERIAL AND METHODS: The study was a double-blind, randomised 4-replicate 4 x 4 Latin square cross-over design. Plaque regrowth was assessed with the Turesky et al. modification of the Quigley and Hein plaque index. The in vivo antibacterial effect was assessed by taking bacterial counts from the tooth surface (smears from the lingual surface of 16) and mucosa (smears from the buccal mucosa) 4 h after the 1st rinse with the preparations on day 1 and prior to the clinical examination on day 5. 16 volunteers participated, and on day 1 of each study period were rendered plaque-free, ceased toothcleaning, and rinsed 2x daily with the allocated mouthrinse. On day 5, plaque was scored and smears were collected according to the protocol. Washout periods were 9 days. Data were analysed using ANOVA with Tukey HSD adjustment for multiple comparisons (significance level alpha=0.05). RESULTS: Mouthrinses A, C, and D were significantly more effective in inhibiting plaque than the placebo (B). Mouthrinse C was significantly better than mouthrinses A and D, while mouthrinses D and A were equally effective in inhibiting plaque. Bacterial count reductions on the tooth surface with mouthrinse C were significantly greater compared to mouthrinse A and the placebo (B). The reduction of bacterial counts on the mucosa with C was significantly greater than with A and B after 4 h and significantly greater than with A, B and D after 5 days. Mouthrinse A reduced bacteria on the mucosa significantly more effectively than the placebo (B) after 4 h and 5 days, while mouthrinse D was more effective than the placebo (B) after 4 h. CONCLUSION: The results indicate that a 0.04% PHMB mouthwash inhibits plaque regrowth and reduces oral bacterial counts, and may be used in preventive applications in the oral cavity.

Adult↗

PubMed2001

Polymorphisms of Fc gamma-receptors RIIa, RIIIa, and RIIIb in patients with adult periodontal diseases.

Polymorphisms influencing the binding affinity between the Fcgamma receptors and IgG of different subclasses are thought to be of importance in the individual susceptibility to infections with Gram-negative bacteria contributing to periodontal disease. One hundred and fifty-four Caucasian subjects were clinically and radiographically examined for their periodontal status and genotyped for their allelic pattern of FcgammaRIIa, FcgammaRIIIa, and FcgammaIIIb polymorphism. In assessing periodontitis according to mean probing depth and attachment loss, no differences were found in allele frequencies or combined allotypes between the subjects with mild or moderate and those with severe signs of periodontitis. However, the extent and severity of bone loss were significantly associated with the genotype of the receptor FcgammaRIIIa. An increased risk of severe bone destruction was observed in individuals carrying the FcgammaRIIIa-VV genotype (OR = 5.3; 95% CI 1.4-26.2). FcgammaRIIIb is in linkage disequilibrium with FcgammaRIIIa. Hence it is also related to periodontal disease. There is no indication of an association between the polymorphism of FcgammaRIIa and periodontitis. The results are evidence that the FcgammaRIIIa genotype coding for the high affinity receptor imposes an additional risk of bone loss as does the FcgammaRIIIb genotype coding for the low affinity receptor.

Adult↗