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Biomedical subjects

T Kishida

Publications and source records attributed to T Kishida.

At least 289 records · Page 16Linked to original sources
PubMed1980

Effect of human leukocyte interferon on the metastatic lung tumor of osteosarcoma: case reports.

Three patients with pulmonary metastases of osteosarcoma underwent treatment with intravenous or intramuscular administration of human leukocyte interferon. In 2 cases, the size of the metastasized tumor mass diminished temporarily six or eight months after interferon treatment, and serum alkaline phosphatase levels decreased to normal. In 1 case, the tumor cell from the pleural exudate 1 could be isolated and cultivated in vitro. When 2,000 IU of interferon was added to the tumor cell culture, marked inhibition of tumor cell growth resulted. In the other case, interferon had no effect on the metastasized lung tumor.

Adolescent↗
PubMed1980

The preventive effect of human interferon-alpha preparation on upper respiratory disease.

Drops of a human leukocyte-derived interferon (HuIFN-alpha) preparation were instilled into the nasal cavity of 86 volunteers once a day from the beginning of December 1977 to the end of March 1978. The rise in hemagglutination-inhibition antibody titers against the three strains of influenza viruses was not significantly different between the interferon group and the control group. However, the rise in antibody titers against the parainfluenza virus, type 2, CA, was less in the interferon group than in the control group. There were fewer complaints of fever resulting from upper respiratory tract disease in the interferon group. Moreover, fevers higher than 39 degrees C were found only in placebo recipients. Fourteen of the 41 volunteers in the interferon group complained of subjective symptoms due to upper respiratory tract infection, whereas 28 of the 43 volunteers in the placebo group complained. This difference was significant. Thus our study indicates that prophylactic administration of an HuIFN-alpha-preparation can influence upper respiratory tract disease.

Administration, Intranasal↗
PubMed1980

Increased nitroblue tetrazolium dye reduction by human neutrophils stimulated by interferon in vitro.

Human leukocyte interferon enhanced nitroblue tetrazolium dye (NBT) reduction by human neutrophils (PMNs). Increase in NBT reduction paralleled increase in interferon dose. When human leukocyte interferon was heated to 60 C or 80 C for 30 min, both the antiviral activity and the effect on NBT reduction decreased. Human leukocyte interferon neutralized with anti-human leukocyte interferon serum showed no effect on NBT reduction. A human fibroblast interferon preparation also enhanced NBT reduction. The species dependency of interferon was shown in NBT reduction as well as in antiviral activity.

Animals↗
PubMed1980

Effect of polychlorinated biphenyl on viral infections in mice.

Mice that were fed a diet containing 400, 200 or 100 microgram of polychlorinated biphenyls (PCB) per g were significantly more susceptible to Herpes simplex virus than mice that were fed a PCB-free diet. The mortality of mice that were fed a diet containing 400 or 200 microgram of PCB per g and infected with ectromelia virus was higher than that of normal control mice infected with virus. There was no significant difference in inducibility of interferon by polyinosinic acid-polycytoidylic acid between PCB-fed mice and control mice.

Animals↗
PubMed1980

Studies on familial amyloid polyneuropathy in Ogawa Village, Japan.

A newly discovered large concentration of familial amyloid polyneuropathy (FAP) in Japan is clinically outlined. The importance of the urinary secretion of IgA in these cases is stressed. Dimethyl sulfoxide administration to these patients induced clinical improvements accompanied by increased excretion of low molecular weight proteins. Amino acid composition of amyloid protein of the Ogawa village-type FAP cases was similar to that of primary amyloidosis.

Adolescent↗
PubMed1980

[Effect of interferon on the inhibition of tumor cell growth by human peripheral leukocytes].

Human leukocyte interferon (HL-IF) enhanced the growth inhibition of tumor cells by the human peripheral leukocytes. There was a dose relation between the enhancement of the growth inhibition of tumor cells and the antiviral activity of interferon. When the ratio of lymphocyte to tumor cell was 10:1 or 50:1, it was recognized that HL-IF enhanced the growth inhibition of tumor cells by lymphocyte. The heterologous IFs--mouse and rabbit IFs--or heat-inactivated or trypsinized IF did not enhance the growth inhibition of tumor cells by lymphocytes. RNase treatment did not reduce the antiviral activity and the growth inhibition.

Cell Division↗
PubMed1980

[Effect of interferon on tumor cell growth inhibition by human peripheral leukocytes. II. Characteristics of effector cells].

The authors clarified the characteristics of effector cells of which inhibitory activity against the tumor cell growth was enhanced by interferon (IF). These cells adhered to nylon wool, but they did not adhere to a glass surface. They showed the EA-rosettees formation, but they did not show the E-rosett formation. This activity was diminished by trypsinization, X-ray irradiation and treatment with hydrocortisone and progesterone. It was not changed by the addition of aggregated Ig. In summary, the effector cells in the present study could not be identical to NK cells.

Cell Adhesion↗
PubMed1980

Synergic effects of interferon and interferon inducer against ectromelia virus infection in mice.

Intraperitoneal injection of mouse brain interferon into mice 24 hr before inoculation of ectromelia virus, significantly reduced the mortality rate and prolonged the mean day of death (MDD). Intravenous injection of Newcastle disease virus (NDV) 24 hr before virus inoculation, also had significant beneficial effects. Furthermore, combined treatment with interferon and NDV had more protective effect against virus infection than either interferon or NDV treatment alone.

Animals↗
PubMed1980

Comparative studies on the inhibitory effects of interferon on various strains of herpes simplex viruses in vitro.

The sensitivities to human leukocyte interferon of 10 strains of Herpes simplex virus (HSV) type 1 and 3 strains of type 2 were compared. All the strains were sensitive to interferon, although their sensitivities were less than that of vesicular stomatitis virus (VSV). There was no significant difference in the sensitivities to interferon of HSV type 1 and type-2 or among different strains of a given type of HSV. Nor was there any difference between the sensitivities of 5-iodo-2'-deoxyuridine (IDU)-sensitive and resistant strains isolated from the same patients. These results suggest that interferon should be useful in therapy of HSV infection.

Cell Line↗