Application of gastrointestinal suture anchor to prevent pericatheter fluid leakage in percutaneous biliary drainage.
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Ascites↗
Biomedical subjects
T Kimoto
Publications and source records attributed to T Kimoto.
Life-threatening esophageal fistula: treatment with expandable metallic stents covered by biosynthetic skin.
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Aged↗
Intravenous leiomyomatosis of uterus: MR appearance.
We report a case with intravenous leiomyomatosis of uterus that showed characteristic appearances on MR. Magnetic resonance demonstrated a tangle of distended and folded tubular structures, well enhanced by Gd-diethylenetriamine pentaacetic acid. It was confirmed by surgery that these tubular structures reflected the vessels markedly dilated by intravascular tumor.
Adult↗
Apoptosis of human leukemia cells induced by Artepillin C, an active ingredient of Brazilian propolis.
Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is an active ingredient of Brazilian propolis that possesses anti-tumor activity. When Artepillin C was applied to human leukemia cell lines of different phenotypes, namely, lymphocytic leukemia (7 cell lines of T-cell, 5 cell lines of B-cell), myeloid and monocytic leukemia and non-lymphoid non-myeloid leukemia cell lines in vitro, Artepillin C exhibited potent cytocidal effects and induced marked levels of apoptosis in all the cell lines. The most potent effects were observed in the T-cell lines. Apoptotic bodies and DNA fragmentation were induced in the cell lines after exposure to Artepillin C. DNA synthesis in the leukemia cells was clearly inhibited and disintegration of the cells was confirmed microscopically. Apoptosis of the leukemia cells may be partially associated with enhanced Fas antigen expression and loss of mitochondrial membrane potential. In contrast, although Artepillin C inhibited the growth of pokeweed mitogen (PWM)-stimulated normal blood lymphocytes, it was not cytocidal to normal unstimulated lymphocytes. These results suggested that Artepillin C, an active ingredient of Brazilian propolis, has anti-leukemic effects with limited inhibitory effects on normal lymphocytes.
Antineoplastic Agents↗
Prevention of azoxymethane-induced intestinal tumors by a crude ethyl acetate-extract and tryptanthrin extracted from Polygonum tinctorium Lour.
The effect of a crude ethyl acetate (AcOEt)-extract and tryptanthrin extracted from the Indigo plant (Polygonum tinctorium Lour.) on azoxymethane (AOM)-induced intestinal tumors was examined in F344 rats. The rats were given subcutaneous (s.c.) injections of either AOM (15 mg/kg body weight (b.w.)) once a week for 3 weeks to induce atypical crypt foci (ACF) as a known cancer precursor, or AOM (7.5 mg/kg b.w.) once a week for 10 weeks to induce intestinal tumors. The rats were also administered the AcOEt-extract (500 mg/kg b.w.) or tryptanthrin (50 mg/kg b.w.) orally, 5 days a week, for 7 or 30 weeks, starting two days before the first administration of AOM. All rats were killed 4 or 20 weeks after the last treatment. In the short-term experiment, the incidence of ACE and atypical crypts (AC) in the groups receiving the AcOEt-extract and tryptanthrin was significantly lower than in the control group. In the tumor-inducing experiment, intestinal tumor incidence in the tryptanthrin group was lower than in the AOM-control group (5% versus 26%), and small intestine tumor incidence in the AcOEt-extract and tryptanthrin groups were lower than in the AOM-control group (0% and 0% versus 23%). These results show that the AcOEt-extract of Indigo and tryptanthrin have cancer chemopreventive activity.
Acetates↗
Multistep carcinogenesis of normal human fibroblasts. Human fibroblasts immortalized by repeated treatment with Co-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogenes.
Two normal mortal human fibroblast cell strains were transformed into immortal cell lines, SUSM-1 and KMST-6, by treatment with 4-nitroquinoline 1-oxide (4NQO) and Co-60 gamma rays, respectively. These immortalized cell lines showed morphological changes of cells and remarkable chromosome aberrations, but neither of them grew in soft agar or formed tumors in nude mice. The immortal cell line, KMST-6, was then converted into neoplastic cells by treatment with Harvey murine sarcoma virus (Ha-MSV) or the c-Ha-ras oncogene derived from a human lung carcinoma. These neoplastically transformed cells acquired anchorage-independent growth potential and developed tumors when transplanted into nude mice. All the tumors grew progressively without regression until the animals died of tumors. In addition, the tumors were transplantable into other nude mice. Normal human fibroblasts, on the other hand, were not transformed into either immortal or tumorigenic cells by treatment with Ha-MSV or c-Ha-ras alone. Our present data indicate that (1) the chemical carcinogen, 4NQO, or gamma rays worked as an initiator of carcinogenesis in normal human cells, giving rise to immortality, and (2) the ras gene played a role in the progression of the immortally transformed cells to more malignant cells showing anchorage-independent growth and tumorigenicity. In other words, the immortalization process of human cells seems to be a pivotal or rate-limiting step in the carcinogenesis of human cells.
4-Nitroquinoline-1-oxide↗
Correlation between mucosal inflammation and marginal bone loss around hydroxyapatite-coated implants: a 3-year cross-sectional study.
In this study, a possible correlation between peri-implant mucosal inflammation and marginal bone loss in a group of patients who received two-stage hydroxyapatite-coated dental implants was evaluated 3 years after implantation. Thirty-two implants were evaluated as to their Plaque Index, Gingival Index, and crevicular fluid volume. Patients were divided into three groups: a control group with no inflammatory signs; a borderline group with moderate inflammation; and a gingivitis group with an established inflammatory process. Three dental radiographs per implant were analyzed at 2 months, 9 months, and 3 years after implantation by measuring bone height at the mesial and distal sides. Preliminary results indicated increased bone resorption in the gingivitis group compared with the control and borderline groups at both the mesial and distal surfaces (P < .05), suggesting correlation between mucosal inflammation and marginal resorption observed around these implants. Statistical analysis of correlation between the assessed mucosal parameters and bone loss indicated significance for Gingival Index and crevicular fluid volume (P < .05).
Alloys↗