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Biomedical subjects

T Kigawa

Publications and source records attributed to T Kigawa.

At least 73 records · Page 4Linked to original sources
PubMed1976

Changes of serum gonadotropin concentrations in fetal and neonatal rat following castration.

Changes of serum concentrations of LH were measured in fetal and neonatal rats following castration. Intact fetal and neonatal male rats showed low levels of serum LH concentration. Though serum LH levels of male rats casterated on the 20th day of gestation did not significantly increase by the 22nd day of fetal age, serum levels of neonatal male rats increased 2-to 3-fold 3 days following castration at all ages studied. The increase was greater in 4-day-old male rats than in 1-day-old males. The increase of serum LH after castration was also found in 4-day-old male rats castrated on the 20th day of gestation. In contrast, serum levels of 1-day-old neonatal female rats did not increase 3-days after castration. These observations suggest sex differences in maturation of the gonadal-hypophyseal feedback mechanism.

Animals↗
PubMed1976

Alterations of insulin-secreting response to glucose in human infants during the early postnatal period.

Oral glucose tolerance tests were performed in healthy infants, aged one to 29 days. Capillary blood samples were obtained from heel stabs for estimation of glucose and insulin immediately before and 30, 60 and 120 minutes after the administration of glucose (2.0g per kg body weight). The younger infants tended to have delayed and diminished insulin responses to a glucose load than did older infants. The ratio of the increment of insulin concentration to the increment of glucose concentration at 30 minutes following a glucose load in younger infants, aged one to 20 days, was below 0.4. The ratio in infants older than 20 days was above 0.5. From these results it is evident that the pancreas of human infants begins to respond to the stimulation by glucose during the early postnatal period and this response becomes even obvious after 20 days of age.

Glucose↗