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Biomedical subjects

T Kidokoro

Publications and source records attributed to T Kidokoro.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Therapeutic effects of cefotiam in biliary tract infections].

As useful antibiotics for biliary tract infections, smooth transmigration to lesion and potent antibacterial activities will be demanded. Usually the antibiotics having potent antibacterial activities against E. coli and Klebsiella, which are considered to be main causative organisms of biliary tract infections, will be used for treatment. The concentrations of cefotiam (CTM) in bile and gallbladder wall tissue were investigated, and CTM showed very high concentrations in these tissues for several hours. And very good correlation between concentration of CTM in bile and laboratory findings, especially ICG R15 value, was obtained. CTM showed also very potent antibacterial activities against E. coli and Klebsiella. These results suggest that CTM will be useful agent for the treatment of biliary tract infections.

Adult↗
PubMed1982

[Plasma exchange therapy in colonic cancer with hepatic metastasis].

The plasma exchange using Carcino embryonic Antigen (CEA) value as an index was performed for 3 colonic cancer patients with liver metastasis. A remarkable regression of hepatomegaly in two cases with rectal cancer was obtained and a significant decrease of CEA was observed in all patients.

Aged↗
PubMed1981

Experimental colonic cancer in a dog.

Experimental colonic carcinoma in a dog was induced by anal insertion of an N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) suppository (each cone containing 50 mg of ENNG) for 17 months. The dog was autopsied 20 months after the initiation insertion of the suppository. Grossly, the colonic wall from the anus of the 10-cm oral side of the colon was thickened, and there was an infiltrating tumor with shallow depressions in the rough mucosa. The lymph node around this portion were enlarged, and white spots were found in the liver and redness in the lungs. Histological examination of the colon revealed a variety of pathologic features, e.g., undifferentiated carcinoma, squamous cell carcinoma and malignant melanoma in the region adjacent to the anus. Well and moderately differentiated adenocarcinomas involving the proper muscle layer were found in a region oral to these tumors and were accompanied by marked invasion of the blood vessels and lymphatic permeation. There were metastases to the liver, lungs and lymph nodes which corresponded to the gross findings, and also metastases to renal glomeruli. A well differentiated adenocarcinoma and signet ring cell carcinoma were evident in the gastric mucosa. This experimental model should be useful for studies related to colonic carcinoma in humans.

Adenocarcinoma↗
PubMed1980

Physiological and light-electron microscopical studies of parietal cells and G cells before and after selective vagotomy with pyloroplasty.

The function of residual parietal cells and G cells following selective vagotomy with pyloroplasty (SV + P) in 21 duodenal ulcer patients was assessed by light-electron microscopical studies of gastroendoscopic biopsy material and determination of gastric acid secretion and serum gastrin levels. The postoperative decrease in number of parietal cells was not so great when compared with the reduction of acid secretion. However, the ultrastructural changes of parietal cells suggested hypofunction of the cells. In addition, the response of parietal cells to histalog stimulation was also decreased according to morphological observations under electron microscope. Basal plasma gastrin was significantly increased (p < 0.01) one month after surgery. Integrated gastrin response (IGR) to meat extract and insulin hypoglycemia stimulation was also increased significantly (p < 0.01) six months postoperatively. The G cells were still increasing in number six months after SV + P, and G cell hyperplasia became more remarkable after one year. Emiocytotic figures were observed in denervated G cells which were stimulated by meat extract or insulin hypoglycemia. On the basis of the findings of this study, it is considered necessary to conduct complete vagotomy on the parietal cell region when SV + P is performed.

Adult↗