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Biomedical subjects

T Kazui

Publications and source records attributed to T Kazui.

At least 253 records · Page 14Linked to original sources

Experimental pulmonary edema: the effect of positive end-expiratory pressure on lung water.

The effect of 10 cm of positive end-expiratory pressure (PEEP) on lung water was studied during pulmonary edema induced in dogs by inflating a Foley balloon placed in the left atrium. Colloid oncotic pressure (COP) was measured directly. Intrapleural pressure (IPP) was measured after surgical closure of the chest. Transmural left atrial (LA) pressure (LA minus IPP) minus COP was considered to be the net force driving water out of the capillaries. LA pressure was elevated so that transmural LA pressure minus COP averaged +7.5 mm Hg. Water accumulation was expressed as the ratio of wet to dry weight. The control ratio of wet to dry lung weight was 4.30 +/- 0.10 (+/- SE). After 2 hours of standardized pulmonary edema and ventilation without PEEP, wet-to-dry lung weight was 5.63 +/- 0.24. In animals ventilated with 10 cm of PEEP through 2 hours of pulmonary edema the ratio was 5.36 +/- 0.14. Animals ventilated with 10 cm of PEEP showed a significant increase in functional residual capacity and decreased intrapulmonary shunt. Ten centimeters of PEEP, however, had no statistically significant effect on water accumulation during experimental pulmonary edema.

Animals↗

Long-term results of bypass grafts for atypical coarctation of the thoracic aorta.

Long-term results of bypass grafts for atypical coarctation of the thoracic aorta are presented. Six of the 13 patients with atypical coarctation were treated with long bypass from the descending thoracic aorta to the abdominal aorta. One of them had correction of right renal stenosis with a saphenous vein graft. Late clinical results of surgery (average follow-up time 4 years, 5 months and the longest over 10 years) were excellent, except for one patient who died 3 1/2 years postoperatively of acute abdomen. This experience suggests that atypical coarctation of the aorta can be treated satisfactorily by the long thoraco-abdominal bypass graft technique. If unilateral or bilateral renal artery stenosis is found simultaneously, renal revascularization is also necessary to obtain normalization of the blood pressures.

Adolescent↗