[Clinical application of diuretics: chronic kidney failure].
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Biomedical subjects
Publications and source records attributed to T Kawada.
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Membranous obstruction of the inferior vena cava (MOVC) is a rare clinical entity. The incidence is higher in Japan and Africa than that in USA and Europe. MOVC is considered to be different from the Budd-Chiari syndrome. There are differences in clinical manifestation and pathologic changes in the liver. Findings of the liver revealed cirrhosis in all patients but in one. Ascites and esophageal varices could be observed in 79% and in 58% of the patients, respectively. According to Sugiura's classification, they consisted of Type Ia in 63%, Type Ib in 11%, Type II in 11%, and Type III in 16%. Portopulmonary shunt by splenopneumopexy was successfully performed on 19 patients with MOVC in this clinic, of which diagnosis was established by cavography.
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Reserpine-induced supersensitivity to the insulin-releasing action of a beta-adrenergic agonist, isoprenaline, and of glucose was studied in vivo and in vitro. The subcutaneous injection of rats with reserpine (0.05 to 10 mg kg-1) enhanced the action of isoprenaline on insulin secretion. ED50 of isoprenaline for insulin secretion was changed little after reserpinization, whereas maximum effect of the beta-agonist was enhanced by pretreating rats with reserpine. Glucose-stimulated insulin secretion was also enhanced in the reserpinized rats. Pancreases isolated from the reserpinized rats secreted more insulin in response to phentolamine in the presence of glucose and isoprenaline. These results suggest that the supersensitivity in insulin secretion induced by reserpine may be non-specific.
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