Biomedical subjects
T Kaufman
Publications and source records attributed to T Kaufman.
The foliage leaf in microvascular surgery.
A lacerated fresh leaf is introduced as a model for developing and refining microvascular skills. Being friable, this plant tissue exaggerates damage due to technical errors, therefore improving a trainee's skills.
The effect of topical hyperalimentation on wound healing rate and granulation tissue formation of experimental deep second degree burns in guinea-pigs.
Revital , a product containing 19 amino acids, was applied to experimental deep second degree burns in guinea-pigs for 24 days, in order to assess the effect of this form of hyperalimentation on the healing process. Silver sulphadiazine cream served as the contralateral control standard. Epithelialization was faster in the silver sulphadiazine treated burn wounds, while contraction of both tested wounds proceeded at a similar rate. Revital significantly enhanced the formation of granulation and scar tissue in this burn wound model. These observations indicate that topical wound hyperalimentation promotes granulation tissue formation of experimental deep second degree burns in guinea-pigs.
The coat burn wound dressing.
A simple and reliable technique to protect experimental burn wounds in guinea pigs is described. This method significantly reduced the accidental removal of dressings, as well as autocannibalism and contamination.
The india ink injection technique to assess the depth of experimental burn wounds.
A detailed description of the India ink injection technique for assessment of experimental burn wound depth is presented with emphasis upon special technical manipulations. Assessment of the burn depth is mandatory for the establishment of a burn wound model as well as to reproduce consistent data among different investigators.
The sonic digitizer: a rapid and accurate method to assess the size of experimental flaps.
Two methods for measuring area, the sonic digitizer and the polar-planimeter, were compared for speed, accuracy, and efficiency. The sonic digitizer was significantly (p less than 0.001) faster than the planimeter (97.2 +/- 9.5 versus 206.3 +/- 14.8 seconds per flap) and more efficient. The accuracy of both methods in measuring areas of 5 to 30 cm2 was comparable; however, for areas of 5 to 13 cm2 the sonic digitizer gave more reproducible results (p less than 0.001). These differences were not reflected in the computed rate of necrosis of the present flap model.
Tobacco smoking: impairment of experimental flap survival.
The survival rate of experimental flaps as affected by exposure to inhaled tobacco smoke has been investigated in rats subjected to different smoking regimens. A distally based dorsal flap was raised and reattached in each animal. Evaluation of the flaps on postoperative day 8 showed a mean rate of necrosis of 28.5% in 25 control animals, 32.2% in 21 rats postoperatively smoking for 7 days, 41.3% in 18 rats preoperatively smoking for 7 days, and 45.7% in 21 rats smoking for 7 days both before and after the surgical procedure. Histological sections from the lungs of the smoking animals revealed a pattern compatible with mild smoke inhalation injury. Arterial oxygen tensions were lower in the tobacco smoking animals. It is assumed that the multiple effects of tobacco smoking contributed to the impairment of experimental flap survival.
The disc dressing for local irrigation of experimental burn wounds.
The newly designed disc dressing permits the surface of experimental burn wounds to be irrigated with liquid therapeutic agents without the need for frequent dressing changes. This approach is simple to handle, reduces the risk of trauma or contamination of the wound, and is not time consuming.
Topical oxygen and burn wound healing: a review.
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The microclimate chamber: morphological aspects of experimental deep burns treated topically with continuous humidified oxygen.
Scanning electron and transmission electron micrographs of tissue biopsies from experimental third-degree burns treated topically with 96% oxygen for twenty-five days, without modifying the environment of the whole animal, revealed a marked promotion of collagen maturation. The O2-treated wounds showed a high ratio of collagen-ground substance; assembling of distinct fibers to form bundles with individual fibers of 1,360 +/- 95 A in diameter and an organized orientation; a highly aggregated rough endoplasmic reticulum of the fibroblasts, consisting of large cisternae and abundant ribosomes. The control burn wounds exposed to ambient air exhibited a low ratio of collagen-ground substance; a loose, rough endoplasmic reticulum; fiber diameter of 700 +/- 70 A, with haphazard orientation of the fibers; and a poor tendency to form bundles. These findings suggest that topical treatment of experimental deep burns with 96% O2 promoted collagen maturation and organization as well as collagen synthesis.
Thermal energy dissipation in blood vessel patency.
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The microclimate chamber: the effect of continuous topical administration of 96% oxygen and 75% relative humidity on the healing rate of experimental deep burns.
The healing rate of small experimental burns continuously treated topically with 96% O2 and 75% relative humidity was followed for 25 days. Serial image photographic magnifications (tenfold throughout) of the wounds enabled precise measurements of their size by means of a polar planimeter. Healing rate was expressed as decreased percentile of wound size on a given day compared to the initial area. The mean percentages of healing +/- SEM of the humidified O2 treated wounds on postburn days 6, 11, and 16 were 31.25 +/- 6.15, 82.09 +/- 3.52, and 98.29 +/- 1.46, respectively, and those for the control wounds were 7.08 +/- 2.20, 47.68 +/- 3.39, and 84.41 +/- 1.38, respectively. Analysis of variance revealed highly significant differences in the healing rate between O2-humidity-treated and control wounds (p less than 0.005). The results indicate that topical treatment with 96% O2 and 75% relative humidity improved healing of experimental burns in guinea pigs.
The influence of various microclimate conditions on the burn wound: a review.
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The microclimate chamber for evaluating burn size and wound healing.
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A method for securing vomerine flaps to the hard palate in the repair of a complete cleft palate.
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Pathologic quiz Case 2: Tonsil showing only slight lymphocytic hyperplasia.
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Biwinged excision for closure of rounded defect.
A new technique for closure of rounded defects is described. The biwinged procedure consists of excising two equal triangles on either side of the defect, one above and one below the dissecting line. Closure is in the form of a step. It can be made to parallel in part a wrinkle or contour line, such as a nasolabial fold, a temporal region above and beside the eyebrow, an area over the lower border of the mandible, or on the dorsum of the hand. A mathematical comparison of the amount of healthy tissue in the biwinged excision and in six other procedures is presented.