[Alexia without agraphia in an ambidexterous patient due to the right occipital lobe lesion].
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Cerebral Infarction↗
Biomedical subjects
T Katsube
Publications and source records attributed to T Katsube.
Effects of naftidrofuryl on the time course of the regional cerebral blood flow in acute ischemic stroke.
The effects of naftidrofuryl (LS-121), which is known as an activator of the cerebral glucose metabolism in addition to acting as a cerebral vasodilator on the regional cerebral blood flow (rCBF), were investigated in acute and subacute ischemic stroke patients. Six acute patients and 5 subacute patients were treated with 100-200 mg/day of naftidrofuryl for 7-14 days, and the rCBF was measured before and after the treatment by the 133Xe inhalation method. The hemispheric rCBF was significantly increased by 24% for the acute stage and 22% for the subacute stage in the affected side, compared with the stage-matched control group. Naftidrofuryl may accelerate the recovery of the rCBF of the affected hemisphere even in the acute stage.
Adult↗
Highly sensitive immunosensor with a surface photovoltage technique.
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Biosensing Techniques↗
New MOS-type glucose sensor using sputtered LaF3 film.
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Biosensing Techniques↗
A new fluoroquinolone derivative exhibits inhibitory activity against human immunodeficiency virus type 1 replication.
The inhibitory activity of several fluoroquinolone antibiotics against human immunodeficiency virus type 1 (HIV-1) replication was investigated. R-71762, (+/-) 9-fluoro-3-fluoromethyl-2, 3-dihydro-10-[4-(2-pyridyl)-1-piperazinyl]-7-oxo-7H-pyrido[1,2, 3-de][1,4]benzoxazine-6-carboxylic acid, protected MT-4 cells from HIV-1-induced cytopathic effects. Furthermore, the compound inhibited virus replication both in acutely and in chronically HIV-1-infected cells. On the other hand, ofloxacin, levofloxacin, ciprofloxacin, norfloxacin and enoxacin, that were previously reported to be protective against HIV-1-induced cytopathic effects, did not show any protective activity in our assay system. These results indicate that R-71762 is a novel inhibitor of HIV-1 replication and is effective even in HIV-1 chronically infected cells.
Anti-HIV Agents↗
Clinicopathological and prognostic significance of thymidine phosphorylase expression in gastric carcinoma.
Tumor growth depends on angiogenesis. Thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth factor (PD-ECGF), and has angiogenic activity. We investigated the expression of dThdPase in 116 gastric carcinoma tissue samples by immunohistochemical staining, and assessed whether its expression was correlated with clinicopathological factors or with the prognosis. dThdPase expression was correlated with clinicopathological factors and may be a good prognostic indicator for gastric carcinoma. To determine whether dThdPase expression was a prognostic factor that was independent of the depth of invasion or lymph node metastasis, we conducted a survival analysis using Cox's proportional hazard model. This analysis revealed that dThdPase expression was the most significant prognostic indicator and was useful for predicting the outcome of gastric carcinoma.
Female↗
Alpha-fetoprotein producing Barrett's esophageal adenocarcinoma: a case report.
A 59-year-old man was admitted to our hospital with upper abdominal pain. His serum alpha-fetoprotein (AFP) level was very high, 1500 ng/ml. Upper gastrointestinal endoscopy revealed depressed lesion at 36 cm from the upper incisors, with columnar epithelium lining the esophagus circumferentially to the oral side of the lesion. Histological examination of biopsy specimens revealed a tubular adenocarcinoma as well as the presence of gastric columnar epithelium with intestinal metaplasia. Immunohistochemistry demonstrated AFP in the tumor cells. From these results, a diagnosis of AFP-producing esophageal adenocarcinoma occurring in Barrett's esophagus, a condition which is extremely rare in Japan, was established. Computed tomography (CT) showed multiple metastasis on the liver and wide-ranging lymph node metastasis. Chemotherapy was not effective and the patient died about 2 months after the start of treatment. The AFP-producing esophageal adenocarcinoma presented here had biological characteristics similar to those of AFP-producing gastric cancer.
Adenocarcinoma↗
Effect of intratumoral OK-432 administration of thymidine phosphorylase expression in human gastric carcinoma.
It is known that thymidine phosphorylase (dThdPase) is increased in various types of malignant tumors and is induced by cytokines. In this study, we have investigated the effects of OK-432, which induces multiple cytokines, on dTHdPase expression and angiogenesis in human gastric carcinomas. We examined 25 patients who underwent gastrectomy for gastric carcinoma. OK-432 was directly injected in tumors in 16 (OK group) of 25 patients via endoscopy before operation and the other 9 patients were not treated (control group). The dThdPase activity in carcinoma tissues of the OK group was significantly higher than that of the control group (P < 0.05). The amounts of IL-1 alpha, IFN-alpha, and IFN-gamma in carcinomas in the OK group were significantly higher than in the controls (P < 0.05), and these were significantly correlated with the dThdPase activity. Intratumoral OK-432 administration enhances the expression of dThdPase in gastric carcinoma cells by inducing various cytokines.
Antineoplastic Agents↗
Study on endoscopic esophageal mucosal resection with ligating device. I--Clinical study.
BACKGROUND/AIMS: EEMRL (endoscopic esophageal mucosal resection with a ligating device) has become increasingly popular. In this article, we review 13 clinical cases of EEMRL. METHODOLOGY: Since 1993, we have performed EEMRL to treat 15 lesions in 13 patients. Twelve squamous cell carcinomas (mucosal cancer in 10 and submucosal cancer in 2) were included among the 15 lesions. RESULTS: EEMRL failed to achieve complete resection of the 2 submucosal lesions (3.0 and 2.8 cm in maximum diameter). However, esophageal lesions could be removed successfully when 2.5 cm or less in maximum diameter. The procedure was not associated with any complication. CONCLUSIONS: Our clinical study showed that this technique may be indicated for esophageal cancer with a maximum diameter < or = 2.5 cm and confined to the mucosa. EEMRL is a technically easy and minimally invasive therapy which could be useful for the treatment of early esophageal cancer.
Aged↗
Study on endoscopic esophageal mucosal resection with ligating device. II--Experimental study.
BACKGROUND/AIMS: This study reports on animal experiments regarding the safety of endoscopic esophageal mucosal resection with a ligating device (EEMRL), as well as the amount of mucosa which can be removed by this technique, the depth of resection and the feasibility of piecemeal resection. METHODOLOGY: Three experiments were performed in six mongrel dogs under general anesthesia. RESULTS: When EEMRL was done without submucosal injection of saline, resection reached the muscular layer and caused esophageal perforation. The average dimensions of the mucosal pieces resected using 8-, 10-, and 12-mm devices was 13 x 10 mm, 18 x 15 mm, and 22 x 18 mm, respectively. Resection reached the mid-plane of the submucosa and the depth was almost uniform. After piecemeal resection, there was no macroscopically visible mucosa at the resection site and each mucosal piece was resected along the mid-plane of the submucosa. CONCLUSIONS: The experimental study indicated that submucosal injection of saline is essential to prevent esophageal perforation. It also showed that EEMRL allows resection up to the mid-plane of the submucosa, that the 12-mm device allows en bloc resection of lesions < or = 15 mm in diameter and that EEMRL is suitable for piecemeal resection.
Animals↗