Isolation of the trimer of compound 48/80 and determination of its histamine-releasing activity.
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Biomedical subjects
T Katsu
Publications and source records attributed to T Katsu.
Compound 48/80-induced permeability change in liposomal membrane.
The action of compound 48/80 (a mixture of condensation products of p-methoxy-N-methylphenethylamine with formaldehyde) on liposomal membranes was studied by means of K+-loaded liposomes and a K+ ion-selective electrode. Prompt efflux of K+ was detected when 48/80 was added to the negatively charged liposome suspension, while the monomer of 48/80, p-methoxy-N-methylphenethylamine, did not release K+ from the same liposomes. The mechanism for the action of 48/80 is discussed in comparison with that of a polymyxin, well known as an antibiotic acting on bacterial membranes.
Kinetics↗
An immunochemical study with potassium ion-loaded liposomes.
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