Search PubMed⌕ Search

Biomedical subjects

T Kasugai

Publications and source records attributed to T Kasugai.

At least 91 records · Page 5Linked to original sources
PubMed1987

Hormonal status of gastric cancer. II. Abnormal constitution of urinary steroids in gastric cancer patients.

We undertook a case-control study regarding the excretions of 14 urinary steroids in gastric cancer (GC) patients. The results are as follows: the levels of androgens, progestins, and two corticosteroids were, relative to tetrahydrocortisol, significantly depressed in GC patients of both sexes compared with the corresponding normal controls. The deviation profile of urinary steroids was not affected by radical gastrectomy. Evidence indicated that observed changes of GC urines were the steroidal expression of a decrease of endogenous testosterone combined with an increase of endogenous hydrocortisone; there was also evidence that the hormonal environment of our GC patients was endocrinologically homologous to that of rice-fed or salty rice-fed mice. Epidemiological inquiry revealed that GC patients having more access to rice-rich or salt-rich diets were taller and less obese than were rural healthy controls. In agreement with the anthropometric data of those cancer patients is the finding that the specific death rate of GC (as calculated for each of 15 prefectures of northern Japan) was positively correlated for each sex with the mean heights, but not with the mean weights, of 14-year-old youths of those areas. This paper discusses the possible relevancy of the hormonal and epidemiological aspects of GC patients to gastrocarcinogenesis in light of steroid physiology.

Adult↗
PubMed1987

Use of endoscopic laser in gastroenterology.

In this presentation we report the current use of endoscopic laser in gastroenterology in Japan with the results of a nation-wide survey and our own experience with more than 100 cases. Nd:YAG laser (photocoagulative therapy) and argon dye laser with hematoporphyrin derivative (photodynamic therapy) were most commonly used in digestive endoscopy, and were investigated as new modalities of cancer therapy and detection. By November 1985, 1588 of gastrointestinal (GI) cancers had been treated in Japan by endoscopic lasers, either as curative or palliative treatment in Japan. Endoscopic laser therapy is "used for" pre-cancerous lesions and early gastric cancer in high risk surgical patients. The Nd:YAG laser at high energy provides a new approach to the palliative treatment, such as relief of neoplastic obstruction in the advanced stage of GI cancers.

Adenoma↗
PubMed1985

Diagnosis of small pancreatic carcinoma.

A retrospective analysis was performed to evaluate the clinical symptoms and abnormal test findings in small pancreatic carcinoma. Five hundred and thirty-six cases of pancreatic carcinoma with the histology of duct cell carcinoma were collected from 14 medical centers in Japan. In 440 of the cases, tumor size was measured at the time of laparotomy or from the resected specimen. Three hundred and seventy-seven patients (86%) had a carcinoma larger than 3.0 cm; only 30% of these were resectable. Sixty-three patients (14%) had a carcinoma of 3.0 cm or less, with resectability of 97%. Detecting a tumor of "3 cm or less" with a high probability of resectability is the objective of early diagnosis with the resulting possibility of a cure. In most cases these small carcinomas were found easily when obstructive jaundice was present (73%). However, the estimated occurrence of obstructive jaundice associated with carcinomas of 3 cm or less was only 10% among the total cases of pancreatic carcinoma studied. Therefore, it is necessary for early diagnosis to detect carcinomas of 3 cm or less presenting without jaundice. The symptoms of small carcinoma without jaundice are weight loss, anorexia, upper abdominal pain, back pain and a palpable abdominal mass. Among the various available examinations, endoscopic retrograde cholangiopancreatography, computerized tomography and ultrasonography were valuable in diagnosing these small carcinomas.

Cholestasis↗
PubMed1984

Correlation between endoscopic retrograde pancreatogram and postmortem.

Endoscopic retrograde pancreatogram and postmortem pancreatograms were compared in 6 dogs. The main duct, branches and acini of the pancreas were opacified adequately in that order with infusion of each 1 ml of contrast medium on 4 occasions in endoscopic retrograde pancreatography, and infusion of each 0.1 ml of the contrast medium on 4 occasions in postmortem pancreatography, respectively. The two pancreatograms were almost identical to the appearance of the main duct, branches and acini. The results suggest that a postmortem retrograde pancreatogram in order to investigate the correlation between the pancreatogram and the histological findings of the pancreas.

Animals↗