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Biomedical subjects

T Kanoh

Publications and source records attributed to T Kanoh.

At least 325 records · Page 18Linked to original sources
PubMed1977

Massive intramedullary globules in IgA monoclonal gammopathy associated with gastric carcinoma.

The bone marrow of a patient with IgA monoclonal gammopathy associated with gastric carcinoma was massively infiltrated with extracellular globules of varying sizes from 2 to 110 micron. These exposed globules were not found in the metastatic lesions heavily infiltrated with plasma cells, but were exclusively confined to the bone marrow. They were indistinguishable from Russell bodies and composed of monoclonal immunoglobulin (IgA, lambda). Of interest is the fact that, despite a small number of plasma cells, there was an intramedullary extensive infiltration of exposed globules. The following conditions may be related to these changes. (1) The globules were not removed rapidly by effectual phagocytosis. (2) The environment of the bone marrow may be favorable for their remaining. In our case, however, the possibility that the plasma cells around the tumor were not of the same clonal origin as the marrow plasma cells cannot be ruled out. (3) The marrow plasma cells may produce immunoglobulin more vigorously, whereas their survival time be shorter than usual. As a result, these exposed globules released on the death of the cells accumulated massively in the bone marrow.

Adenocarcinoma, Papillary↗
PubMed1976

IgA deficiency and systemic lupus erythematosus. Occurrence in an oriental woman with idiopathic epilepsy.

A 25-year-old Oriental woman developed systemic lupus erythematosus during a course of treatment with carbamazepine for long-standing idiopathic epilepsy. Serum IgA was virtually absent, while secretory IgA was quantitated in a small amount in the saliva and gastric juice. Results of immunofluorescent studies on the rectal mucosa and bone marrow did not show any IgA-producing plasma cells. Antibodies against IgA, IgM, milk protein, and bovine serum were detected in the serum. The ability to develop both circulating antibodies and delayed hypersensitivity against test antigens was suppressed. Enumerations of T lymphocytes and IgG and IgM B lymphocytes were within normal limits, whereas IgA B lymphocytes were decreased in number. Results of chromosomal analyses disclosed various abnormalities.

Adult↗
PubMed1976

[Angiographical extravasation of contrast material in traumatic epidural hematomas--the clinical significance and surgical indication (author's transl)].

During the last 17 years since 1958, 108 cases with traumatic epidural hematomas were treated in our clinics, and the extravasation from the middle meningeal artery was observed in 20 cases (18%) out of them. The clinical significance of the extravasation will be discussed in association with the indication of surgical intervention. Common carotid angiographies were performed in all of 20 cases, and selective external carotid angiographies were also performed in 2 of them. The time interval from the injury to the angiographical confirmation of extravasation ranged from an hour to ten days. In 14 cases, it was confirmed at the acute stage less than 3 days after the injury, and in the remaining 6 cases it was confirmed at the subacute stage more than 3 days after the injury. Surgical removal of the hematomas was performed in 16 cases, and no surgery was done in the other 4 cases mainly because of slight hemorrhage in the cranial cavity. The extravasation from the middle meningeal artery, which was usually observed to overlap the fracture line or in the neighbourhood of it, was classified into the following three types according to the angiographic contours: 1. Estravasation of contrast material into the perivascular tissue (11 cases): Though it was stated in the literatures that this type of extravasation was usually observed less than 6 hours after the injury, it was confirmed at the subacute stage in our 3 cases out of 11, and even ten days later in a case. Angiographically, it is demonstrated to be an irregular band-like configuration (3 cases), scattered spots (2 cases), round shadow (2 cases), semicircular contour (2 cases) or irregular maplike shadow (2 cases), all of which changed in shape and density through the arterial phase to the end of the venous phase. All of the 11 cases showed large epidural hematomas, and the angiographical extravasation coincided with the site of actual bleeding which was confirmed at the operation. 2. A berry-shaped well-defined round shadow of high density communicating with the arterial lumen--pseudo-aneurysm-like shadow (2 cases): In one, a berry-shaped shadow was discovered in the angiography performed 17 hours after the injury. A small cavity which was surrounded by epidural clot and communicated with the middle meningeal artery was discovered at the operation, and considered to be the site of actual bleeding, since an arterial bleeding through the cavity was noticed. In the other, a berry-shaped shadow which appeared as soon as the middle meningeal artery was demonstrated and disappeared by the late venous phase was angiographically discovered 10 days after the injury. A epidural hematoma was slightly formed and operation was not performed. Two months later, the pseudoaneurysm-like shadow was not demonstrated angiographically. 3...

Adult↗
PubMedDate not supplied

Suppression of in vivo tumor-induced angiogenesis by the protein-bound polysaccharide PSK.

The anti-angiogenic effects of an antitumor protein-bound polysaccharide, PSK, obtained from cultured mycelia of Coriolus versicolor in basidiomycetes were examined by the mouse dorsal air sac assay. PSK suppressed the mouse hepatoma MH134-induced angiogenesis when assessed by morphological and biochemical examinations. This finding suggested that the anti-metastatic effect of PSK is attributed to the suppression of tumor-induced angiogenesis.

Animals↗
PubMedDate not supplied

Immunohistochemical analysis of cytokeratin #8 as a prognostic factor in invasive breast carcinoma.

Cytokeratin #8 (CK8) was analysed by immunohistochemistry using a monoclonal antibody in 101 operable invasive breast carcinomas (IBCs). The immunohistochemical staining pattern, and its correlations with patient characteristics and prognosis were studied. Sixty-five (65%) out of 101 patients had CK8 positive tumors. The incidence of CK8 positivity in patients with estrogen receptor (ER) positive tumors was significantly higher than that in patients with ER negative tumors. The same tendency was seen between the CK8 positivity and progesterone receptor (PR) status; however, no statistical significance was found. Furthermore, the incidence of CK8 positivity in premenopausal patients was lower than that in postmenopausal patients with no statistical significance. Relapse-free survival (RFS) for patients with CK8 positive tumors was significantly better than that for patients with CK8 negative tumors. The multivariate analysis of factors related to RFS showed that CK8 staining positivity was an independent prognostic indicator of IBCs. These results suggest that CK8 expression may be one of the prognostic factors of IBCs.

Antibodies, Monoclonal↗
PubMedDate not supplied

Enhancement of the antitumor effect by the concurrent use of a monoclonal antibody and the protein-bound polysaccharide PSK in mice bearing a human cancer cell line.

The antitumor effects of a monoclonal antibody against a human cancer cell line and a protein-bound polysaccharide, PSK, obtained from cultured mycelia of Coriolus versicolor in basidiomycetes were examined. The IgG2a monoclonal antibody against the human colon cancer cell line colo 205 induced in vitro antibody-dependent macrophage-mediated cytotoxicity against the cancer cells, but only slightly suppressed the in vivo growth of the cancer cells. Concurrent use of PSK with the antibody enhanced the in vitro antibody-dependent macrophage-mediated cytotoxicity as well as the in vivo antitumor activity. These findings suggest that the combined use of a monoclonal antibody and PSK, which have different modes of action, may be useful in the treatment of cancer.

Animals↗