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Biomedical subjects

T Kanoh

Publications and source records attributed to T Kanoh.

At least 253 records · Page 14Linked to original sources
PubMed1984

Transient autoantibodies with elevated complement levels in common viral diseases.

Autoantibodies including rheumatoid factor (RF), anti-DNA antibody (ADA), and anti-nuclear factor (ANF) in addition to cold agglutinin and heterophil antibody titers were tested for in a total of 219 patients with common viral diseases. The diseases included varicella, influenza, measles, mumps, herpes zoster, hand-foot-mouth syndrome, and exanthem subitum . A high incidence of RF (23%) was demonstrated in varicella patients, and ADA and ANF (16% and 12%, respectively) were most frequently detected in the influenza cases. Those autoantibodies were most frequently found in patients with influenza. Each serum complement component and total hemolytic complement (CH50) were also assayed. Elevated levels of the fourth (C4) and ninth (C9) components of complement, along with elevated CH50, were observed in most patients. Follow-up studies indicated that those autoantibodies as well as other antibodies disappeared 3 to 8 weeks after the onset of infection. The present study indicates that substantial but transient alterations in the immune system accompanied by autoimmune phenomena and elevated levels in the complement components can occur in viral infections.

Adolescent↗
PubMed1983

Coronary neovascularity related to a left ventricular mural thrombus.

Thirty-six patients with the angiographic diagnosis of left ventricular mural thrombus were reviewed. All had a history of myocardial infarction. In 9 of these patients (25%), coronary neovascularity was related to a left ventricular mural thrombus. Although no relationship was found between either the size of the mural thrombus or the duration of illness and the neovascularity, the incidence of neovascularity was low in a group taking anticoagulants. Arteriographic characteristics of the neovascularity in the present cases are: 1) In all cases, the neovascularity arose from the left anterior descending coronary artery. 2) The neovascularity consisted of a hypervascular region in the same location as the mural thrombus. It was observed as a dense mass of small vessels penetrating the left ventricle in a form resembling a toothbrush. 3) The neovascular region had no veins and it extended through the narrow gap of the thrombus to communicate with the left ventricle. Histological studies were consistent with coronary arteriography. The demonstration of neovascularity by coronary arteriography suggests either that the thrombus is relatively new or that a new thrombus is further organized on the old thrombus. This seems to be useful information from a therapeutic viewpoint.

Coronary Angiography↗
PubMed1982

Ultrastructure of vacuolated plasma cells in macroglobulinemia associated with production of Mu-chain fragment.

In a unique case of macroglobulinemia associated with the production of mu-chain fragment, the authors observed vacuolated plasma cells (Vac-P) in the bone marrow. Immunofluorescence with anti-mu-chain showed positive staining for the cytoplasm but negative for the vacuoles. On electron microscopic study, clear vacuoles were localized in the vicinity of the Golgi complex, and the contents were amorphous membrane debris and concentric circular structures. The vacuolar membrane was partially disrupted and was contiguous with the outer surface of the concentric circular structure. From the findings, the authors thought these vacuoles were autophagic. Disruption of vacuolar membranes was also demonstrated in three other cases of Vac-P studies with electron microscope. Heterophagy of toxic substances, such as silica or salt or urate, leads to membrane disruption. Vac-P observed in abnormal mu-chain production may produce toxic substances. Once the substance is incorporated into the autophagic vacuole, the vacuolar membrane will be weakened, and the absorption of part of the membrane and cytoplasm or organelles follows.

Aged↗
PubMed1982

Intracellular immunoglobulin in lymphocytes from patients with chronic lymphocytic leukemia: an immunoelectron microscopic study.

The presence of ultrastructural distribution of intracellular immunoglobulin (Ig) in leukemic cells from patients with chronic lymphocytic leukemia (CLL) and in normal B cells were investigated by an immunoelectron microscopic technique. Most normal B cells had no intracellular Ig in spite of the presence of surface Ig. However, leukemic cells from 10 to 11 patients with CLL contained intracellular Ig and showed various staining patterns. In eight patients, Ig was present in the perinuclear space (PN), the endoplasmic reticulum (ER) and, if identified, the Golgi complexes. In four patients, most cells had diffuse staining of the cytoplasm. In five patients, Ig was detected in the ER-associated structures or the vesicles, in addition to the PN and ER. These findings suggest that CLL cells have a greater capacity to produce Ig than those of normal B cells and include various clones with distinct staining patterns of intracellular Ig.

B-Lymphocytes↗
PubMed1982

Squamous cell carcinoma associated with disturbance of the IgA system.

A case of cell carcinoma of the skin associated with disturbance of the IgA system is described. Immunological observations revealed a marked low level of serum IgA and disturbance of the secretory IgA synthesis in the rectal mucosa. After the surgical removal of the skin tumor, the serum level of IgA was increased to half the normal-range level. The relationship of the disturbance of the IgA system to the occurrence of squamous cell carcinoma is discussed.

Aged↗