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Biomedical subjects

T Kamiya

Publications and source records attributed to T Kamiya.

At least 487 records · Page 27Linked to original sources
PubMed1976

Nocardicin A, a new monocyclic beta-lactam antibiotic II. Structure determination of nocardicins A and B.

The structures of nocardicins A and B, novel monocyclic beta-lactam antibiotics produced by a strain of Nocardia, have been established as 1 and 2, respectively, on the basis of spectroscopic and chemical evidence. They are the first examples of monocyclic beta-lactam antibiotics possessing relatively high antimicrobial activity, and are stereochemically and biologically related to penicillins and cephalosporins.

Anti-Bacterial Agents↗
PubMed1975

Daunorubicin, cytosine arabinoside, 6-mercaptopurine riboside, and prednisolone (DCMP) combination chemotherapy for acute myelogenous leukemia in adults.

Thirty-seven adults with acute myelogenous leukemia (AML) were treated with a combination of daunorubicin, cytosine arabinoside, 6-mercaptopurine riboside, and prednisolone (DCMP) for remission induction. Twenty-three of 37 patients (62.2%) achieved complete remission, three, partial remission and 11, failure. Patients with prior therapy responded as well as patients without it. The median survival time of the patients who received DCMP for their initial remission induction therapy was 10.3 months and that of the patients who obtained complete remission was 17 months. Complete remission occurred in 21 out of 28 patients (75%) less than 40 years old but in only two out of nine patients (22.2%) more than 40 years old. The most common toxic effects were severe myelosuppression and liver function abnormalities. DCMP therapy is an effective remission induction chemotherapy for adults with AML.

Adolescent↗
PubMed1975

Two molecular forms of thymidine kinase in the cytosol of regenerating rat liver.

Two forms (Peak A and Peak B) of thymidine kinase [EC 2.7.1.75] from regenerating rat liver cytosol were resolved and partially purified by Deae-cellulose chromatography. Both fractions were identical with respect to their substrate requirement, pH optima, metal requirements, and molecular weight, as judged by their sedimentation in sucrose density gradient centrifugation. Peak B differed from Peak A in heat sensitivity, inhibition by dCTP and Km for thymidine and ATP. Peak B enzyme was the only enzyme found in normal adult liver and Peak A enzyme was the form increasing predominantly in regenerating liver.

Animals↗
PubMed1975

Viridenomycin, a new antibiotic.

Viridenomycin, a new crystalline antibiotic, was isolated from the culture broth of Streptomyces viridochromogenes strain No. T-24146. Viridenomycin is a weakly acidic and lipophilic substance, which exhibits a strong absorption maximum at 310 nm and shows strong activity against Trichomonas vaginalis and gram-positive bacteria.

Animals↗