Treatment results of 9,741 cases of gastric cancer treated at the Cancer Institute Hospital, Tokyo during the past 42 years were retrospectively analyzed. Resectability was 89.6% (94.1% for 1960-1988) and operative mortality was 1.9% (1.5% for 1960-1988). Five-year survival rate was 48.5% (54.9% for 1960-1988) for all cases, 68.8% (73.1% for 1960-1988) for patients with curative surgery, and 4.7% (4.9% for 1960-1988) for those with noncurative surgery. Curative rate was improved twofold among patients with curative gastrectomy. Postoperative adjuvant chemotherapy had a marginal benefit for stage II and III disease. Improvement could be attributed mainly to the relative increase in early gastric cancer, and partly to the extended surgeries for stage III and IV cases, such as systemic lymphadenectomy and combined resection of involved adjacent organs. Multimodality therapy is expected to control the relapse of peritoneal dissemination (14.2%) and hematogenous metastasis (8.9%).

Antineoplastic Combined Chemotherapy Protocols↗

PubMedDate not supplied

Prognostic and therapeutic values of peritoneal cytology in gastric cancer.

Exfoliative cytology of peritoneal lavage was performed at the time of laparotomy for 458 patients with gastric cancer. Positive cytologic specimens were obtained from 28 per cent of all cases and from 16 per cent of patients with curative surgery. Peritoneal cytology has revealed itself to be a good predictor of prognosis and an indicator for adjuvant therapies. In the group treated with curative surgery, the five year survival rate was 86 per cent for patients with intact serosa and negative cytologic specimens, and 52 per cent for patients with involved serosa and negative cytology. None of the patients who had involved serosa and positive cytologic specimens survived more than five years. A slight benefit of adjuvant chemotherapy was observed in the patients who had curative surgery with negative cytology. Long term immunochemotherapy, including repeated intraperitoneal administration of mitomycin-C, improved the lifespan of patients with non-curative surgery.

Ascitic Fluid↗

PubMedDate not supplied

Studies on five-year survivals after surgery for gastric carcinoma.

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Humans↗