Biomedical subjects
T Kajii
Publications and source records attributed to T Kajii.
Cri du chat syndrome.
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Thalidomide experience in Japan.
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Serum proteins in vesicular fluid of hydatidiform moles: a lack of selectivity of molar trophoblast in the transfer of maternal serum proteins.
Complete hydatidiform moles, an abnormal pregnancy of androgenetic origin consisting of swollen villi without an embryo, were studied to determine the protein constitution of vesicular fluids in the swollen villi and the ability of the molar tissue to synthesize protein. All 16 serum proteins tested were identified in the molar fluid. A reverse correlation was obtained when the logarithms of the molar fluid versus maternal serum concentration ratios of different proteins were plotted against the logarithms of their molecular weights. Logarithmic regression analysis showed a linear regression with a high coefficient (gamma = 0.9626). Phenotyping of haptoglobin in the molar fluid and in the parental sera indicated a definite contribution of maternal proteins to the molar fluid. The molar tissues synthesized no serum proteins but produced human chorionic gonadotrophin beta-subunit (hCG-beta) and pregnancy-specific beta 1-glycoprotein (SP1) when examined in tissue cultures metabolically labelled with [35S]methionine. These findings indicate that a variety of maternal serum protein components is transferred to the molar fluid without being selected by the molar trophoblastic cells.
Detection of antibodies to human T-lymphotropic viruses type I and III in Japanese hemophiliacs.
Sera of 65 hemophiliacs, 85 hemodialysis patients and 304 healthy volunteer blood donors in Japan were tested for antibodies against both HTLV-I and -III by an indirect immunofluorescence and radioimmunoprecipitation assay. The results showed that 10 (15.4%) of the hemophiliacs were anti-HTLV-III positive, while all other subjects were anti-HTLV-III negative. All groups contained subjects positive for anti-HTLV-I. The prevalence of the antibody in the hemophiliacs (17.4%) and hemodialysis patients (9.4%) was significantly high as compared to that of healthy controls (1%).