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T Kaji

Publications and source records attributed to T Kaji.

196 records · Page 11Linked to original sources
PubMedDate not supplied

Interaction of zinc with cadmium and copper on ossification of embryonic chick bone in tissue culture.

Histological changes are shown of ossification induced by a simultaneous exposure to zinc and cadmium or to zinc and copper using embryonic chick femur in a culture system. Cadmium caused an atrophic change of the osseous tissue in the absence of zinc but caused an osteomalacic change with a partial degenerative change in the presence of zinc after a 6-day culture. Copper caused an atrophic change in the absence or presence of zinc. These observations were partly supported by the fact that the diaphysial calcium content was significantly decreased by zinc alone, and the decrease was unaffected by cadmium or copper. Zinc significantly decreased cadmium accumulation but not copper accumulation in the diaphysis. Thus, in spite of the inhibitory effect on calcification, zinc prevented a decrease in bone matrix formation caused by cadmium but not that by copper. Exposure of chick femur culture to zinc and cadmium induced changes consistent with osteomalacia, i.e., decreased mineralization of bone, with or without suppression of matrix formation. Exposure to zinc and copper, however, induced changes consistent with osteoporosis, i.e., decreased mineralization and matrix formation.

Animals↗
PubMedDate not supplied

Successful transcatheter embolization of penetrating aortic ulcer using interlocking detachable coils.

A 54-year-old man with persistent chest pain was hospitalized for hypertension and DeBakey type IIIb aortic dissection. The false lumen of the dissection was almost completely thrombosed; however, a penetrating atherosclerotic ulcer (PAU) was observed 5 weeks later. At that time, we successfully embolized the PAU with a microcatheter and interlocking detachable coils (IDCs). The patient is well with no episodes of relapse in 20 months of follow-up. This case suggests the utility of the microcatheter and IDC system as an alternative to surgery.

Aortic Dissection↗
PubMedDate not supplied

Cadmium-induced alteration of glycosaminoglycans with an enhancement of heparin-like activity in cultured vascular endothelial cells.

Glycosaminoglycans (GAGs), especially heparan sulfate, are involved in the anticoagulant property of vascular endothelium. It was observed that heparin-like activity on the surface of cultured bovine aortic endothelial cells was enhanced by cadmium at 1.0 microM or more after a 24-h incubation. The incorporation of [3H]glucosamine into GAGs, a marker of GAG synthesis, was markedly increased by cadmium at 0.5 microM or more in both the cell layer and the conditioned medium; however, the incorporation of [35S]sulfate, a marker of the GAG sulfation, was significantly reduced by the metal at 2.0 microM or more. Similar changes were observed in a cultured human umbilical vein endothelial cell layer. Characterization of GAGs in bovine endothelial cell layer revealed that cadmium (2.0 microM)-induced alterations mostly occurred in the major component heparan sulfate rather than in other minor GAGs. Stimulation of [3H]glucosamine incorporation by cadmium at 2.0 microM occurred even in the presence of p-nitrophenyl-beta-D-xyloside but disappeared in the presence of cycloheximide, suggesting that cadmium might induce the production of proteins which are involved in GAG synthesis. The present data suggest that vascular endothelial cells are capable of enhancing the potential anticoagulant activity on their surface via induction of heparan sulfate synthesis. This response of endothelial cells may be a defensive one to the procoagulant state of blood which can be induced by cadmium.

Animals↗
PubMedDate not supplied

The effects of cadmium on a clonal osteogenetic cell, MC3T3-E1: inhibition of calcification and induction of metallothionein-like protein by cadmium.

To clarify the effects of cadmium (Cd) on bone formation, a clonal osteogenetic cell, MC3T3-E1, was used in the present study. After 24 h of culture, Cd at 1 ppm and above decreased DNA synthesis and alkaline phosphatase activity, but Cd at 1.5 ppm caused no significant decrease in collagen content. The cells treated with Cd (0.03-1.0 ppm) for 24 h showed the dose-dependent effects on metallothionein-like protein synthesis. The marked increase of Cd content unbound to metallothionein (MT)-like protein with cadmium at 1 ppm may be responsible for the toxic effects of cadmium. After 10 days of culture, the accumulation of 45Ca to the cell layer decreased with increasing level of cadmium at 0.03 and 0.1 ppm. The cadmium-treated cell layer showed a weaker reaction to histochemical staining for mineral compared with control culture. This result suggests that Cd inhibits an initial process of calcification.

Alkaline Phosphatase↗
PubMedDate not supplied

CT demonstration of fibrous stroma in chronic pancreatitis: pathologic correlation.

Fibrous stroma found in two patients with chronic pancreatitis was investigated. The helical CT-pathologic correlation confirmed that fibrous stroma found in the subcapsular zone of the pancreatic parenchyma corresponded to the area that was identified as a hypodense zone in the early phase by spiral CT and became isodense with the internal parenchyma in the delayed phase. These CT findings have an important implication for the diagnosis of chronic pancreatitis.

Aged↗
PubMedDate not supplied

Superior mesenteric varices and splenic renal shunt with portal hypertension: a case report of liver cirrhosis with complications.

The case of a 58-year old woman with cirrhosis complicated by hepatocellular carcinoma, hepatic encephalopathy and superior mesenteric varices is described. Angiography revealed large superior mesenteric varices and it was demonstrated that the portal venous blood was shunted into the right internal iliac vein via the right ovarian vein. Clinically, this patient had hepatic encephalopathy and hyperammonaemia, but no oesophageal varices were discovered on endoscopy. The hepatic encephalopathy suggested that the portal blood containing ammonium from the superior mesenteric vein entered the brain through the systemic vein without the ammonia being metabolized by the liver.

Carcinoma, Hepatocellular↗