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Biomedical subjects

T Kadono

Publications and source records attributed to T Kadono.

44 records · Page 3Linked to original sources

PubMed1977

Biological active polycycloalkanes. 4. Phosphoric esters of trimethylenenorbornyl alcohols.

Secondary (6) and tertiary (8) phosphates of exo-5,6-trimethylenenorborn-exo-2-yl alcohol (exo-tricyclo-[5.2.1.0(2,6)]dec-exo-8-yl alcohol, 3) and a secondary ester (9) of a mixture of exo-tricyclo[5.2.1.0(2,6)]dec-3-en-8- and -9-yl alcohol (2) were prepared. The most convenient route to 6 was direct esterification of phosphoric acid with 3. 9 was obtainable by the addition of phosphoric acid to endo-dicyclopentadiene (1). These phosphates were tested in vitro for antiviral activity against Newcastle disease virus using a monolayer culture of chick embryo fibroblasts. 6 was found ca. twice more potent than, while 8 was as active as, amantadine hydrochloride under the present test conditions.

Animals↗

PubMed1973

[Thin-layer chromatography on precoated adsorbents fixed with fused glass. V. Thin-layer chromatography on Kieselguhr sintered plate].

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Chromatography, Thin Layer↗

PubMed1972

Thin-layer chromatography on silica gel-sintered plates.

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Alkaloids↗

PubMed1972

[Thin-layer chromatography on precoated adsorbents fixed with fused glass. IV. A consideration on the welding mechanism of alumina sintered plate for thin-layer chromatography by means of scanning electron microscopic method].

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Alkaloids↗

PubMed1972

[Thin-layer chromatography on precoated adsorbents fixed with fused glass. II. Thin-layer chromatography on alumina sintered plate].

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Aluminum↗

PubMed1966

[Studies on the effects of mitomycin C in the patients with malignant tumors, particularly on changes in serum iron, serum copper and iron binding capacity. 2. Clinical effects].

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Copper↗

PubMed1966

[Studies on the effects of mitomycin C in the patients with malignant tumors, particularly on the changes of serum iron, serum copper and iron-binding capacity. 3. Changes in iron with Fe 59 before and after mitomycin C administration in normal rabbits and patients with gastric cancer].

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Animals↗

PubMedDate not supplied

Endothelial function evaluated by flow-mediated dilatation in pediatric vascular disease.

The endothelial function of children with and without vascular disease, consisting of 41 controls, 24 with Kawasaki disease (KD), and 46 with diabetes mellitus (DM), was examined. Age at examination ranged from 3 to 23 years (mean, 12.0 +/- 4.7). The flow-mediated dilatation (FMD) and intima-media complex in the common carotid artery were measured. In controls age at examination was not associated with FMD or intima-media complex. FMD significantly decreased in children with KD and DM compared with the control group (control vs KD or DM: 11.7 +/- 14.7 vs 3.0 +/- 11.0 or 6.4 +/- 8.5%, respectively; p < 0.05). However, there was no significant difference for intima-media complex among the groups. Furthermore, FMD in KD patients with coronary arterial aneurysm was lower than that in KD patients without aneurysm (-0.5 +/- 9.2 vs 8.3 +/- 9.1%, p < 0.05). In DM patients, FMD in the high HbA1c group (HbA1c = 7%) was lower than that in the normal HbA1c group (HbA1c < 7%) (4.8 +/- 8.1 vs 11.4 +/- 7.8%, p < 0.05). In conclusion, FMD detected endothelial impairment in children with KD or type 1 DM regardless of overt vascular complications, and FMD impairment occurs prior to intima-media complex thickening. By measuring both FMD and intima-media complex, useful information for predicting vascular complications may be obtained.

Adolescent↗