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Biomedical subjects

T Kaburagi

Publications and source records attributed to T Kaburagi.

At least 55 records · Page 3Linked to original sources
PubMed1983

Two forms of hypertrophic cardiomyopathy distinguished by inheritance of HLA haplotypes and left ventricular outflow tract obstruction.

In this study we have performed human leukocyte antigen (HLA)-A and B typing on nine patients with hypertrophic cardiomyopathy (HCM) and their relatives. Four patients had relatives who also had the disease. HLA typing of the familial form of HCM revealed a very close association of a given HLA-A,B haplotype with the occurrence of the disease. All four patients who had affected relatives had obstruction of left ventricular outflow (LVOT), while four patients with unaffected relatives did not have obstruction. One additional patient with obstruction and without familial incidence was an only child and had few living relatives. Thus, HCM can be divided into two subtypes: a familial form linked to the HLA-A,B system, which may be related to obstructive type, and a sporadic form not linked to HLA antigens. These data confirm the existence of at least two separate forms of hypertrophic cardiomyopathy. The study also confirms their existence in the Japanese population, with a completely different gene pool than the population from the southeastern United States in whom the observation was initially described.

Adolescent↗
PubMed1982

Familial congestive cardiomyopathy with positive rheumatoid factor. Report of one family.

Three members of one family had cardiomyopathy of the congestive type. Autopsies of 2 brothers revealed marked dilatation of the left ventricle with diffuse interstitial fibrosis of unknown origin. The father's diagnosis was based on clinical findings. In one brother, a positive latex fixation test for rheumatoid factor had been documented when he were healthy. Another brother had a positive test for rheumatoid factor almost simultaneously with the onset of the disease. It remained positive until both died. Thus, the positive rheumatoid factor presumably reflected primary or independent immunologic defects rather than a secondary immunologic mechanism in these cases of familial congestive cardiomyopathy.

Cardiomyopathy, Hypertrophic↗
PubMed1981

Korean hemorrhagic fever among rural residents in Japan.

Naturally occurring infection with Korean hemorrhagic fever virus among four families living in rural areas of northern and central Japan was proved by the demonstration of antibody to the virus. Furthermore, Korean hemorrhagic fever virus antigen was detected in the lung tissues of wild rodents captured in the endemic area. These findings indicate the endemic presence of Korean hemorrhagic fever virus on Honshu Island, Japan.

Animals↗