Biomedical subjects

T K Taylor

Publications and source records attributed to T K Taylor.

At least 145 records · Page 8Linked to original sources

PubMed1975

Morphological studies of the canine intervertebral disc. The assignment of the beagle to the achondroplastic classification.

The morphological development of the epiphyseal growth plate and intervertebral discs of newborn and nine-month-old beagles, greyhounds and dachshunds have been studied. On the basis of the cellular and matrix development of these canine tissues together with the known characteristics associated with achondroplasia it is concluded that the beagle should be assigned to the chondrodystroid breed classification.

Achondroplasia↗

PubMed1975

Variations in collagen, non-collagenous proteins, and hexosamine in menisci derived from osteoarthritic and rheumatoid arthritic knee joints.

Knee joint menisci from osteoarthritic and rheumatoid knees were analyzed for nitrogen, collagen, non-collagenous proteins (NCP) and hexamine content. Degenerate areas were analyzed separately. The degenerative areas were significantly lower (P less than 0.005) in collagen but NCP and hexosamines were elevated relative to control tissue. The rheumatoid menisci revealed a reduced level of collagen and hexosamine in areas of localized degeneration. However, the collagen and hexosamine content of the remaining tissue was also diminished (P less than 0.025) relative to normal tissue of the same. age.

Adult↗

PubMed1975

The origins and relative distribution of polysaccharidases in rheumatoid and osteoarthritic fluids.

Three lysosomal polysaccharidases were measured in synovial fluid (SF) and serum from rheumatoid (RA) patients, SF from osteoarthritic (OA) patients, and serum from healthy volunteers. (1) There was no correlation between the enzyme levels and white cell counts in the SF. (2) beta-glucuronidase and beta-N-acetylglucosaminidase were markedly elevated in the SF of RA as compared to OA. (3) beta-glucuronidase and beta-N-acetylglucosaminidase levels in the SF of RA correlated well with each other but not with hyaluronidase. (4) beta-glucuronidase and beta-N-acetylglucosaminidase levels were higher in the SF of RA than in the corresponding serum, while the converse was true for hyaluronidase. (5) Hyaluronidase levels were significantly higher in RA serum than in normal serum. These results suggest that the synovial membrane may be the source of beta-glucuronidase and beta-N-acetylglucosaminidase, while hyaluronidase is derived from a source remote from the joint via the serum. This source of hyaluronidase may be the liver. (J Rheumatol 2: 393-400, 1975).

Acetylglucosaminidase↗

PubMed1975

Genetic factors in the maturation of the canine intervertebral disc.

The composition and structure of the intervertebral discs have been studied in a group of six four-month-old beagles which were full or half-siblings. The animals were raised in identical environment and were comparable weight and size at sacrifice. Collagen, hexosamine, uronic acid, sialic acid and non-collagenous protein analysis (via indirect method) were performed on the nucleus pulposus (NP), transitional zone (TZ) and a annulus fibrosus (AF) of the discs for the lumbo-sacral, lumbar and thoracic spinal levels. Parallel histochemical and morphological examinations of the discs were also performed. The knee joint meniscus, and articular cartilage was also examined for the components described. The results of the analysis for the discs revealed that within this single age group there co-exist two statistically different compositional states. These differences reside largely in the NP and TZ regions and from the analytical values are interpreted as indicating the chondroid and non-chondroid conditions. No such compositional variation was observed for articular cartilage and fibrocartilage (knee joint menisci).

Animals↗

PubMed1974