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Biomedical subjects

T K Hunt

Publications and source records attributed to T K Hunt.

At least 181 records · Page 10Linked to original sources
PubMed1975

Some aspects of wound healing research: a review.

Mammalian response to injury essentially is that of tissue repair and re-epithelialization. The most important component of repair tissue is collagen, and after injury collagen turnover is greatly increased. Collagen biosynthesis is initiated by nuclear DNA of fibroblasts; the steps in biosynthesis are complex but studies of collagen biosynthesis may eventually have clinical potential. Normally, wound healing lasts for up to 2 years but nutritional and metabolic factors, such as malnutrition, delay healing; hyperalimentation would likely be beneficial under these conditions. Other factors that influence wound healing are the oxygen tension in tissues, the hemodynamic status, and the effects of substances such as cortisone, vitamins A and C, and zinc.

Animals↗
PubMed1975

Breast biopsies on outpatients.

One hundred and three excisional biopsies of breast masses were done on an outpatient basis under local anesthesia. The criteria for selecting patients were such that only two malignant tumors were found, and 101 unnecessary hospital admissions were avoided. A large majority of patients responding to our survey accepted or even preferred the outpatient, local anesthetic technique. Thirteen of 16 patients who had previous inpatient biopsies under general anesthesia preferred biopsy as an outpatient under local anesthesia. This idea is not new, but new economic and social conditions as well as developing diagnostic techniques now increase its potential value.

Adolescent↗
PubMed1974

Effect of malnutrition on colonic healing.

It has been suggested that colonic healing is impaired in malnourished subjects, but there have been no biochemical studies of the effect of malnutrition on colonic healing. The effects of malnutrition on the colon and the healing of colonic anastomoses were studied in rats fed a protein-free diet. Test animals were compared with control animals of similar age, and control animals of similar weight. There was a significant reduction in the body weight, total serum proteins and serum albumin of animals starved of protein. Malnutrition resulted in a reduction in the weight of the uninjured colon, and an increase in the colonic collagen concentration. There was a significant reduction in the collagen content of the colon in animals starved of protein for seven weeks, and the collagen content of anastomoses in these animals was significantly lower than the value in control animals. Anastomotic edema occurred during colon healing in animals starved for seven weeks. Measurements of colonic bursting pressure were an inaccurate guide to colonic healing. It is concluded that severe malnutrition resulting in 34% loss of body weight had an adverse effect on colonic healing.

Animals↗