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Biomedical subjects

T K Dutta

Publications and source records attributed to T K Dutta.

At least 55 records · Page 3Linked to original sources
PubMed1996

Clubbing--a reevaluation of its incidence and causes.

117 adult patients (age > 13 years) admitted in medical wards were studied for clubbing. 24.8% (29/117) of the patients had clubbing. Incidence of clubbing in males and females was 22.2% (26/117) and 2.6% (3/117) respectively [corrected]. Liver disease, which was seen in 27.6% cases (8/29) of clubbing, was the commonest cause of clubbing and was observed only in males. This was related to a high incidence of alcohol intake among males i.e. 34.6% (9/26) as against none among the females. Amongst the liver disease, suppurative liver disease was responsible for clubbing in 75% (6/8) of cases. Only 20.7% (6/29) of patients with clubbing had severe clubbing. 66.6% (4/6) of patients with severe clubbing had liver disease. Congenital heart disease was cause of clubbing in 2 out of 3 females (66.6%) with clubbing. Alcohol may be causally related to occurrence of clubbing in this part of the country.

Adolescent↗
PubMed1995

Tetanus caused by human bite of the finger.

A case of generalized tetanus after human bite of the finger is reported. The patient recovered with institutional care. We propose that secondary invasion by Clostridium tetani is the cause for infection. It could be prevented by immediate tetanus prophylaxis, thorough debridement, and primary repair of the wound.

Adult↗
PubMed1994

Microsomal glutathione S-transferase (GST) isozymes in Aspergillus ochraceus TS: induction by 3-methylcholanthrene.

Induction of microsomal glutathione S-transferase isozymes in Aspergillus ochraceus TS is reported. Among the inducers of mammalian drug-metabolising enzymes 3-methylcholanthrene, benzo(a)pyrene and polychlorinated biphenyl enhanced the microsomal GST activity quite considerably. On the other hand phenobarbital, beta-naphthoflavone and trans-stilbene oxide were almost without any effect. To our knowledge this seems to be the first report on induction of microsomal GST in lower eukaryotes. A significant increase (7.9 fold) in GST activity was observed with the cells induced by 3-methylcholanthrene. Moreover, three new GST isozymes were found to be present in 3-methylcholanthrene induced microsomes. The isozymes are basic in nature. The GST isozymes were found to be catalytically distinct from each other.

Aspergillus ochraceus↗
PubMed1994

Treatment of clinical rabies in man: drug therapy and other measures.

The treatment of symptomatic rabies is a challenging problem; no specific drug is yet available. Isolation in intensive care unit with symptomatic and supportive measures is the mainstay of treatment at present. Antiviral drugs, particularly interferon and interferon-inducers, have been employed with variable results. Corticosteroid is not effective. Anti-rabies vaccine has no proven efficacy in treatment. Effective treatment of systemic complications during survival period with appropriate therapy is essential.

Antiviral Agents↗
PubMed1993

Onset of new catalytic activity in immobilized spores of Aspergillus ochraceus TS due to in situ germination: C17-C20 lysis accompanies 11 alpha-hydroxylation of steroid.

The change in product pattern during transformation of progesterone by calcium alginate entrapped spores of Aspergillus ochraceus TS (A. ochraceus TS) due to germination in situ is reported. While progesterone was transformed exclusively to its 11 alpha-hydroxy derivative by both free and immobilized spores of A. ochraceus TS, the latter germinated in situ by yeast extract furnished 11 alpha-hydroxyprogesterone and C19 steroids during transformation under identical conditions. The characterization of metabolite(s) and the pathway proposed demonstrated that delta 1-dehydrogenation and lysis of C17-C20 bond are apparently two independent reactions. The change in product profile due to activation of immobilized spores is believed to be caused by accumulation of compatible solutes in the biocatalyst which had relatively low water content.

Aspergillus ochraceus↗
PubMed1992

Local and systemic eosinophilia in patients with carcinoma of the uterine cervix undergoing radiation therapy: correlation with radiation response.

Forty-nine patients with squamous carcinoma of the uterine cervix undergoing supervoltage 60Co radiotherapy were investigated to determine the significance of quantitation of eosinophils in the tumour tissue as well as in blood. The blood absolute eosinophil count (AEC) at presentation was higher in patients with Stages III and IV disease (0.52 +/- 0.09 x 10(9)/l, mean +/- SEM) when compared with early stages (Stages I and II, 0.35 +/- 0.07 x 10(9)/l). Forty-four patients (90%) showed a steady rise in AEC during the course of therapy. The patients showing good radiation response (n = 13, greater than or equal to 50% regression), displayed a more pronounced rise in AEC during the course of radiotherapy (0.66 +/- 0.24 x 10(9)/l) and had more eosinophils in the tumour tissue (7.4 +/- 0.66/oil immersion field) than the poor responders (n = 36, less than 50% regression, rise in eosinophil count 0.22 +/- 0.04 x 10(9)/l, eosinophils in tumour tissue 2.9 +/- 0.55/oil emersion field, P less than 0.0001 for both parameters). We conclude that quantitation of eosinophils in blood and tumour tissue before and during radiotherapy in patients with squamous carcinoma of the uterine cervix is useful in predicting radiation response.

Blood Cell Count↗
PubMed1992

Quinine blindness.

A young women was treated with intravenous quinine and chloramphenicol for suspected severe malaria and/or typhoid fever. On the second day of quinine therapy (after 2.25 g of quinine) she suddenly developed total bilateral loss of vision. Both drugs were stopped and cyclandelate therapy was started. She showed slight improvement in vision but on referral her visual acuity was limited to seeing waving hand movement only; visual fields were constricted and colour vision was absent. Both pupils were fixed and dilated. The fundi showed macular oedema and attenuated retinal arteries. She was treated with dexamethasone, cyclandelate, vitamin B complex and vitamin C. Colour vision was completely recovered after 5 days of treatment. Full recovery of the direct light reflex occurred after 10 days. Visual acuity improved slowly over a period of one month to 6/15 vision in both eyes. At this time macular oedema and retinal arteriolar attenuation were still present but less severe. In the context of this case report the condition of quinine blindness is briefly reviewed and the management discussed.

Adult↗
PubMed1992

Human rabies: modes of transmission.

In contrast to past experience, transmission of rabies by routes other than bite or licking by rabid animals has been identified in recent years. Man to man spread via corneal transplant is a well recognised phenomenon now. Airborne infection in caves as well as in laboratories among workers dealing with rabies virus has been well documented. There is also a potential risk of infection to attendants of rabies patients. Hence, adequate protective measures should be adopted.

Animals↗