Biomedical subjects
Publications and source records attributed to T Johnson.
Organisational roles and systems are a reflection of professional group norms, says Tony Johnson of the West Midlands RHA personnel division. He suggests that professionals need to be encouraged to be aware of how their expectations affect their particular service, and thus the patient.
The work and retirement decisions of husbands and wives are likely to be made jointly as they allocate their available resources. This article models the allocation of family wealth and family members' time over the lifetime of the unit. The first section reports simulation results that illustrate the relationship between the value of members' time in both market work and the production of home services. The model is then tested by means of the Retirement History Study for 1969-73. The estimation is conducted by employing a simultaneous logit model of labor-force participation by the husband and wife. Principal findings are: (1) Individuals respond positively to increases in their own wage rate but tend to reduce labor-force participation as the wage rate of their spouse increases, (2) the health of the husband is an important determinant of his labor-force participation, and (3) the probability that a person will be in the labor force is raised if the spouse is employed.
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Two infants with meningitis who were treated with phenobarbitone and high-dose chloramphenicol showed progressive falls in the peak blood levels of chloramphenicol. A standard chloramphenicol dose of 50 mg/kg daily would have produced subtherapeutic blood levels after only a few days. The importance of measuring serial blood chloramphenicol concentrations is stressed.
The accuracy and practicality of particle size distribution analysis for rapid screening of urine specimens are assessed. Six hundred urines were subjected simultaneously to routine bacteriological examinations and particle size distribution analysis using a Coulter Counter (ZBI) linked to a C1000 Channelyzer. There was complete agreement in the results of 593 (98.8%) specimens. Characteristic profiles of various bacterial species in infected specimens were consistently obtained. This system can easily be linked to any existing computer reporting in a district hospital laboratory, and the results of negative specimens (70--80%) can be obtained within 5--10 minutes.
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A care is described of an astrocytoma grade 1 arising from the floor of the third ventricle, operated upon transcallosally. No disconnection symptoms were produced. Five years later the patient has above normal intelligence and is attending school at normal grade level in spite of a CT scan suggesting recurrence of the tumor.
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Dendrodendritic synapses from swine olfactory bulbs were isolated by homogenization of the gray layer, followed by centrifugation at 1000 X g. Centrifugation of the supernatant at 10,000 X g revealed that all dendrodendritic synapses had pelleted at 1000 X g. The upper portion of the 1000 X g pellet was further purified in a discontinuous sucrose gradient, and each resultant fraction was examined by electron microscopy. The dendrodendritic synapses band below the 1.2-1.4 M sucrose interface, appear to be minimally contaminated with other membranous elements, and have retained their adhesions. The banding pattern and relative amounts of proteins from dendrodendritic synaptosomes were very similar to those of axonal synaptosomes as determined by electrophoresis on polyacrylamide gels containing sodium dodecyl sulfate (SDS) and 8 M urea.
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Brain and spinal fluid were obtained post mortem from an individual with multiple sclerosis who died following carbon monoxide inhalation. Electron microscopic examination of the plaque region revealed a crystalline structure (repeat unit 380 to 410 A) within rough endoplasmic reticulum of astrocytes, a paracrystal (160 to 220 A) within the cytoplasm of astrocytes, and rigid tubules (outer diameter 320 to 450 A) within a cell in the lumen of a capillary. The paracrystal was enclosed by the glial fibrils. A second crystalline material was observed within cells in the 15,000 X g pellet from spinal fluid. The ultrastructural pattern of this second crystal was generated by three sets of parallel lines; a given set was intersected by the other two sets. The crystal had only two different repeat units (410 to 450 A; 310 to 350 A) since the smaller dimension was common for two sets of lines. The two crystals were large; the one in astrocytes had a length of 52,000 A and that in spinal fluid sediment was 62,000 A. These structures were observed in the one multiple sclerotic brain obtained at autopsy but were not detected in multiple sclerotic brains that had been frozen for extended periods. Plaque regions and grossly normal white matter were homogenized and the 1000 X g supernatant of this material was fractionated in a continuous CsCl-sucrose density gradient. Long tubules (320 to 500 A diameter) were observed in the 1.24 to 1.26 density region. The major proteins of the 1.24 to 1.26 fraction had molecular weights clustered at 40,000 to 45,000, 88,000 to 130,000, and 300,000.
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