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Biomedical subjects

T Jeck

Publications and source records attributed to T Jeck.

24 records · Page 2Linked to original sources

[Using drugs: experiences with a slide show program and patient questionnaires].

200 patients were surveyed by questionnaire while attending the medical outpatient service at the university hospital of Zürich. Questions related to a slide show on the usage of prescribed drugs presented at the same time in the attending room but also to general personal habits and attitudes regarding pharmacotherapy. Appreciation of the slide show was remarkable. This was substantiated by the observation that next to the physician media such as news papers, television and broadcast serve as source of information on drugs. Patient-compliance was in part related to lack of correct information. While older patients discontinued treatment because of side-effects, younger patients stopped drugs often because of improvement under therapy. In depth information could improve compliance in the latter population since particularly these individuals complained about insufficient instruction. The personal preference of "natural" over "chemical" drugs was surprisingly at variance with the admission of regular intake of prescription drugs--possibly a sign of an ultimately greater confidence in "chemical" drugs.

Audiovisual Aids↗

[Acute facial swelling, pruritus].

This patient developed facial edema with impressive swelling of the inferior lip within a few hours. He had experienced several episodes with transient, itching swelling at diverse sites over the past six months. This history and the rapid disappearance of symptoms after intravenous corticoids were suggestive of Quincke's edema. Since testing for possible causes remained unsuccessful idiopathic Quincke's edema was diagnosed.

Adult↗

Blood pressure self-measurement in normotensive and hypertensive patients.

In this study casual blood pressure was compared with home blood pressure measurement in 41 normotensive, 39 hypertensive and 21 borderline hypertensive subjects. The average casual readings for the whole group were 8.6 mmHg higher for systolic and 4.0 mmHg higher for diastolic pressures than self-determined values. Casual and home-registered blood pressures showed a highly significant relationship (P less than 0.001) for both systolic and diastolic blood pressure readings. In the distribution of self-measured diastolic blood pressure readings, normotensive subjects rarely (5%) showed values higher than 90 mmHg, whereas hypertensive subjects had a relatively high percentage of diastolic readings above that level (55%). The results confirm previous reports of lower self-determined than casual blood pressure values. However, the high correlation between these two methods of blood pressure measurement indicates that in general there is a quantitative rather than a qualitative difference between casual and self-registered blood pressures. Finally, self-registered diastolic values exceeding 90 mmHg may be interpreted as hypertensive.

Adult↗

[Diagnostic value of atrial natriuretic peptide in hypertension and heart insufficiency].

Serum ANP levels were measured by radioreceptor assay in 40 patients with various forms of secondary hypertension and 6 patients with heart failure. In addition, serum ANP was determined in 4 patients with renal artery stenosis before and after dilatation, as well as in 5 anephric patients before and after haemodialysis. Our results showed elevated serum ANP level in most patients with various forms of secondary hypertension and chronic heart failure. A distinction between these two groups and a control group of healthy individuals was not possible due to the wide range and occasional normal levels in the first two groups. ANP levels in patients with renal stenosis decreased after dilatation but there was no correlation with the success of this procedure. A positive correlation between ANP and plasma renin level was detectable in patients with renal artery stenosis, but was also elevated in anephric patients with absent renin production. In summary, our results show that measurements of serum-ANP are of little significance in the diagnosis of hypertension and chronic cardiac failure.

Atrial Natriuretic Factor↗

[Rational diagnosis of endocrine forms of hypertension].

Primary aldosteronism, Cushing's syndrome and pheochromocytoma are the most frequent endocrine hypertensive disorders. Following biochemical confirmation of the clinical diagnosis, mainly non-invasive imaging techniques are necessary to determine the cause of the hormone excess. Diagnosis of primary aldosteronism is confirmed by analysis of aldosterone and renin in peripheral venous blood. Differentiation between adenoma and idiopathic adrenal hyperplasia usually is achieved by computed tomography and isotope scan. A reliable test for the biochemical confirmation of Cushing's syndrome is the determination of urine-free cortisol. In patients with equivocal results the dexamethasone suppression test is performed. Differential diagnosis between ACTH-dependent Cushing's syndrome (pituitary or ectopic) and primary adrenal disorders can be made by determination of plasma-ACTH and -cortisol. Non-invasive localization procedures include computed tomography of the abdomen, computed tomography or magnetic resonance imaging of the pituitary gland, sonography and isotope scan. Diagnosis of pheochromocytoma is based on elevated catecholamine levels in urine or plasma. The tumor is localized by ultrasound, computed tomography or isotope scan.

Adrenal Gland Neoplasms↗