Biomedical subjects
Publications and source records attributed to T Jacobsen.
A simple, accurate and precise high-performance liquid chromatographic method for determination of iopentol in urine and serum is presented. The modifications of the method necessary for the determination of some other non-ionic contrast agents and in other biologic fluids are also presented.
The autoclaving studies which were performed to develop a formulation of iopentol are presented. The same formulation as used for iohexol was found to be suitable for iopentol. It was shown that it is essential to use a buffer such as trometamol to lower the pH during autoclaving in order to achieve a low level of deiodination after autoclaving. Results from the on-going stability studies indicate a good stability of iopentol finished product.
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In order to describe the incidence, distribution, and prognosis of neonatal cancer, 76 cases (44 boys, 32 girls) of cancer in the first 28 days of life were identified in the Danish Cancer Registry within the period 1943-1985. All cases were reevaluated and the International Classification of Disease for Oncology (ICD-O) code was applied. The incidence is calculated to 2.38 (1.88-2.98) cases per 100,000 births. The most common tumor was neuroblastoma (26%) followed by leukemias (16%), soft-tissue sarcomas (14%), and brain tumors (11%). The 5-year survival rate was 25% (15.1-39.0) with the highest survival rate among soft-tissue sarcomas (55%) and neuroblastomas (25%) and the lowest among leukemias and brain tumors (0). Eighteen percent of the cases were incidental findings. Two cases of secondary malignancy were identified.
The absorption of the nonionic contrast medium iohexol, the clearance tracer 51Cr-ethylenediaminetetraacetic acid, and the blood-pool marker 125I-human serum albumin was studied after subarachnoid and subdural injection in rabbits. Subdural deposition of the contrast medium and 51Cr-ethylenediaminetetraacetic acid resulted in a faster absorption rate and higher achieved blood levels than a subarachnoid injection of the two substances, where a slow absorption to lower blood concentrations was observed. No significant differences in absorption rate could be shown after subdural and subarachnoid administration of iodine-labelled albumin. The excretion of iohexol was observed for 1 week after the intrathecal injection. For both the subdural and subarachnoid depositions, about 83% of the injected iohexol was found in urine within 24 hr after injection. The total recovery of iohexol after 1 week was 96% (range, 87%-101%).